UCB SA, of Brussels, Belgium, said data from a double-blind, placebo-controlled study found that Neupro (rotigotine transdermal system) reduced total nocturnal systolic blood pressure (NSBP) elevations associated with periodic limb movements during sleep (PLMS) and total PLMS in patients with idiopathic moderate to severe restless legs syndrome (RLS)/Willis-Ekbom disease

The randomized, double-blind, placebo-controlled 11-week trial is expected to enroll about 180 treatment-seeking cocaine-dependent subjects at approximately 12 U.S

The NH004-3 clinical trial is a double-blind, placebo-controlled, randomized, crossover, multicenter study comparing NH004 and placebo thin films in Parkinson's disease patient complaining of sialorrhea

The double-blind, randomized, placebo-controlled study will enroll 21 participants with burn scars that restrict range of motion of jointed areas such as elbows, shoulders and fingers...The randomized, double-blind, placebo-controlled study (209AS208) evaluated the safety, tolerability and efficacy of arbaclofen in 150 ASD subjects, ages 5 to 21 years, with a particular focus on social function

The randomized, double-blind, parallel group trial is evaluating TC-1734 against donepezil (Aricept, Pfizer Inc.) in approximately 300 patients at sites predominantly in Eastern Europe and the U.S. The Alzheimer's Disease Assessment Scale-cognitive subscale and the Clinician Interview-Based Impression of Change Plus Caregiver Input, or CIBIC-(+), are co-primary endpoints, with the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory replacing CIBIC-(+) as a co-primary

The primary objective of the double-blind, randomized, single ascending dose study is to evaluate the safety and tolerability of rHIgM22 in subjects with MS...The primary endpoint of the randomized, double-blind, placebo-controlled trial is the effect of repeat oral dosing of the Cav2.2 selective blocker on the pain experienced in PHN after three weeks, compared with baseline

Ceregene Inc., of San Diego, reported top-line data from its double-blind, randomized, controlled Phase IIb study of CERE-120 (AAV-neurturin), a gene therapy designed to deliver the neurotrophic factor neurturin, for Parkinson's disease...The double-blind study enrolled 34 patients who received placebo or one of three different doses of LL-37

The 26-week, double-blind, randomized, parallel group, placebo-controlled trial will evaluate change in percent atheroma volume after 26 weeks of treatment, with safety and tolerability as secondary endpoints, as well as changes in ApoA-I, HDL-, HDL-subclasses and non-HDL lipid parameters...The company expects to report top-line results of the multicenter, randomized, double-blind, placebo-controlled, parallel group trial by year-end

MRI assessments were performed as a quantifiable and objective measure of SMF volume and thickness in the multicenter, randomized, double-blind, placebo-controlled Phase IIb study (ATX-101-09-15), which also demonstrated positive results based on validated clinician- and patient-reported outcome measures

OncoGenex Pharmaceuticals Inc., of Vancouver, British Columbia, said an investigator-sponsored, randomized, double-blind, placebo-controlled Phase II trial of OGX-427 in non-small-cell lung cancer (NSCLC) will be initiated to evaluate whether the drug in combination with carboplatin and pemetrexed can extend progression-free survival...The randomized, double-blind trial will enroll about 250 patients on stable, optimized, guideline heart failure therapy with symptoms of fluid overload to receive 15

The multinational, randomized, double-blind, placebo-controlled study reached the recruitment goal of 120 patients with treatment-refractory ulcerative colitis

The randomized, double-blind, placebo-controlled study will evaluate the safety, tolerability and pharmacokinetics of single-ascending doses of APD334 in up to 64 healthy adult volunteers

The randomized, double-blind, placebo-controlled trial will enroll 108 patients at about 30 sites in the U.S

The randomized, double-blind, placebo-controlled Phase I trial is designed to assess the safety, tolerability and pharmacokinetics of single ascending oral doses of CK-2127107 in a three period, escalating dose, crossover design. (See BioWorld Today, Sept. 11, 2012

The placebo-controlled, randomized, double-blind study will evaluate the efficacy, safety, tolerability and immunogenicity of blisibimod in patients with clinically active lupus who have not achieved optimal resolution of their disease with corticosteroid use

Convergence Pharmaceuticals Ltd., of Cambridge, UK, reported interim data from the ongoing Phase II trial testing sodium channel blocker CNV1014802 in patients with trigeminal neuralgia, a severe form of facial pain, showing that, in the open-label portion, a total of 70 percent had a successful response and were subsequently randomized into the double-blind treatment period

The global, double-blind, placebo-controlled study enrolled 666 patients with ABSSSI at 95 sites

The randomized, double-blind, placebo-controlled, 26-week trial assessed the efficacy and safety of Cialis 5 mg once daily or placebo co-administered with finasteride in 696 men 45 years and older with an IPSS of at least 13, a urine flow rate of 4 mL/sec to 15 mL/sec and a prostate volume at least 30 mL

The randomized, double-blind, placebo-controlled trial will be carried out in the UK with a primary objective of safety and tolerability of single and multiple doses of subcutaneous ALN-TTRsc...The double-blind, randomized, placebo-controlled trial will assess safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple-escalating doses of the drug in healthy adults