clinical trials where a single dose of NX-1207 has been found to produce on average symptomatic improvements about double that reported for currently approved BPH drugs without causing the sexual or cardiovascular side effects associated with those drugs

One patient suffered serious adverse events that led to discontinuation, but all other side effects were mild and transient

GAL-021 was well tolerated with side effects similar to placebo

The company has found in studies to date that a single dose of NX-1207 produces symptomatic improvements about double those of currently approved BPH therapies without sexual or cardiovascular side effects...Common side effects of muscarinic antagonist therapies also were assessed in the 138 patients enrolled in the trial, with patients on the Tolenix arm showing statistically significant improvements in OAB and UUI symptoms over placebo

XmAb5871 is the first in a new class of therapeutic antibodies targeting the CD32b (FcγRIIb) pathway in B cells, which shows potential to suppress autoimmune disorders without the side effects caused by B-cell depletion, the company said

Infradure, a subcutaneous autologous skin tissue implant, is designed for the continuous production and delivery of interferon-alpha, to replace months of weekly injections and thereby reduce interferon side effects

No significant adverse events related to the drug occurred, and Nymox said NX-1207 treatment for BPH was not associated with the sexual, cardiovascular or other side effects associated with approved BPH medications

Patients receiving Tolenix, a twice-daily combination of muscarinic antagonist tolterodine and muscarinic agonist pilocarpine, exhibited no safety issues and also demonstrated statistically significant and clinically meaningful improvements in their saliva production and dry mouth side effects, as compared to Detrol

In the Phase I trial, 40 healthy volunteers who do not use methamphetamine received the medication over the past eight months and experienced no serious side effects

Subjects had no significant side effects or complaints

He also experienced no serious side effects from SL-401 treatment

The product was well tolerated, with no serious side effects reported, and Aerie said it plans to advance into Phase IIb testing

DPX-Survivac was found to be safe and well tolerated, with no systemic side effects or dose-limiting toxicities to date

Consistent with the results previously reported for the study, PRX302 continued to be well tolerated with no erectile function side effects during the 12 months following treatment

The highly potent ROCK inhibitor is based on Amakem's localized drug action platform, which generates novel kinase inhibitors that minimize the risk of systemic as well as local side effects, such as hyperemia

Side effects were generally mild to moderate and, at the highest dose in some subjects, the improved lung ventilation was sufficient to increase in minute ventilation by more than 50 percent and in parallel lower CO2 levels more than 25 percent

The treatment regimen was well tolerated, with transient flu-like symptoms and transient leukopenia as the most common side effects related to JX-594

Tetraphase Pharmaceuticals Inc., of Watertown, Mass., reported Phase II data at the Interscience Conference on Antimicrobial Agents and Chemotherapy in San Francisco, showing that eravacycline (TP-434) was highly active against drug-resistant bacterial pathogens, demonstrating infection cure rates similar to that of comparator ertapenem for the treatment of complicated intra-abdominal infections and a strong safety profile, with low rates of gastrointestinal side effects

Prior studies also showed that more than 90 percent of TC-5214 is eliminated unchanged through the bladder, supporting use of a low dose and creating the potential to minimize unwanted side effects. (See BioWorld Today, Nov. 9, 2011