Pexa-Vec is currently being evaluated in an international, randomized Phase IIb trial (TRAVERSE) in patients with advanced primary liver cancer who have failed sorafenib therapy

PharmaMar SA, of Madrid, a subsidiary of Zeltia SA, said it completed enrollment in its Phase IIb study testing PM01183 vs

The Phase IIb study allows for a head-to-head comparison of the commonly used chemotherapeutic agent doxorubicin with aldoxorubicin, CytRx's tumor-targeting doxorubicin conjugate...Data from the Phase IIb trial is expected in the second half of 2013

Seaside Therapeutics Inc., of Cambridge, Mass., said its Phase IIb trial evaluating arbaclofen (STX209) in core impairments of autism spectrum disorder (ASD) failed to show improvement on the primary endpoint of social withdrawal but demonstrated improvement on the clinical global impression of severity scale

Oxygen Biotherapeutics Inc., of Morrisville, N.C., said it initiated the second cohort of its Phase IIb trial of Oxycyte in patients with severe, nonpenetrating traumatic brain injury (TBI

Targacept Inc., of Winston-Salem, N.C., said it completed patient recruitment in the Phase IIb study of TC-1734, an alpha4beta2 neuronal nicotinic receptor, in mild-to-moderate Alzheimer's disease

Acucela Inc., of Seattle, said it started a Phase IIb/III trial of emixustat hydrochloride for geographic atrophy associated with dry age-related macular degeneration

Ceregene Inc., of San Diego, reported top-line data from its double-blind, randomized, controlled Phase IIb study of CERE-120 (AAV-neurturin), a gene therapy designed to deliver the neurotrophic factor neurturin, for Parkinson's disease

Resverlogix Corp., of Calgary, completed dosing in a Phase IIb (ASSURE) trial of RVX-208 in patients with low HDL and ApoA-1 at high risk for cardiovascular events...Targacept Inc., of Winston-Salem, N.C., said it completed patient recruitment in the Phase IIb study of TC-5619 to treat negative symptoms and cognitive dysfunction in schizophrenia

MRI assessments were performed as a quantifiable and objective measure of SMF volume and thickness in the multicenter, randomized, double-blind, placebo-controlled Phase IIb study (ATX-101-09-15), which also demonstrated positive results based on validated clinician- and patient-reported outcome measures

Sorbent Therapeutics Inc., of Sunnyvale, Calif., began dosing patients in a Phase IIb trial (STEPWISE) of CLP-1001 in congestive heart failure

Ltd., of Seoul, South Korea, said they completed the Phase IIb trial of Tarafenacin, in development for treating overactive bladder syndrome...Photocure ASA, of Oslo, Norway, reported final results from its Phase IIb study of Cevira in patients with human papillomavirus (HPV)-related disease of the cervix, showing that the drug-delivery device demonstrated significant and sustained efficacy in the eradication of oncogenic HPV infections and precancerous lesions in CIN2 patients

NovaBay Pharmaceuticals Inc., of Emeryville, Calif., enrolled first patients in Brazil into its global Phase IIb trial, BAYnovation

Sarepta Therapeutics Inc., of Cambridge, Mass., reported updated data from Study 202, a Phase IIb open-label extension study of eteplirsen in Duchenne's muscular dystrophy (DMD

Aastrom Biosciences Inc., of Ann Arbor, Mich., enrolled its first patients in a Phase IIb trial of ixCELL-DCM to assess safety and efficacy of ixmyelocel-T in advanced heart failure that is caused by ischemic dilated cardiomyopathy...Biogen Idec Inc., of Weston, Mass., said results of a daclizumab high-yield process (DAC HYP) Phase IIb trial were published online in The Lancet

CureVac GmbH, of Tubingen, Germany, said it started a Phase IIb trial testing RNActive cancer vaccine CV9104 in patients with castration-resistant prostate cancer...Neurocrine Biosciences Inc., of San Diego, said it started a Phase IIb trial testing elagolix, an oral gonadotropin-releasing hormone antagonist, in uterine fibroids

Biothera Inc., of Eagen, Minn., said it completed enrollment of its 90-patient Phase IIb study testing Imprime PGG, Avastin (bevacizumab, Roche AG) and two chemotherapeutic drugs in non-small-cell lung cancer

Lithera Inc., of San Diego, said the first patient was treated with LIPO-202 (salmeterol xinafoate for injection) in its 500-patient Phase IIb RESET trial

Poxel SA, of Lyon, France, said it started a Phase IIb trial of imeglimin in Type II diabetes