CytRx Corp., of Los Angeles, reported initial data from a Phase Ib trial evaluating the pharmacokinetics and safety of aldoxorubicin in patients with metastatic solid tumors who have either relapsed or not responded to standard treatment...The data from a randomized, double-blind, placebo-controlled Phase Ib multiple ascending dose study showed that PRM-151 was generally safe and well tolerated in patients with idiopathic pulmonary fibrosis
PharmaMar SA, of Madrid, Spain, a subsidiary of Grupo Zeltia, began a dose-finding, Phase Ib trial with lurbinectedin (PMO1183) combined with capecitabine in advanced solid tumors
OncoMed Pharmaceuticals Inc., of Redwood City, Calif., began a Phase Ib/II trial of its anti-Notch2/3 antibody (OMP-59R5), triggering an $8 million milestone payment from GlaxoSmithKline plc, of London...In Phase Ib, the trial will explore dose escalation and expansion
PharmaMar SA, of Madrid, Spain, a subsidiary of Zeltia, said it completed a Phase Ib trial testing PM01183 in combination with doxorubicin, with the combination displaying antitumor activity in all types of cancer included in the study
These data led to Eleven's Phase Ib clinical study of EBI-005 in subjects with dry eye disease, with top-line data from the Phase Ib study expected in the second half of 2013
Isis Pharmaceuticals Inc., of Carlsbad, Calif., started a Phase Ib/IIa study of ISIS-STAT3Rx in patients with advanced metastatic hepatocellular carcinoma (HCC
Neuralstem Inc., of Rockville, Md., received approval from the FDA to begin dosing the third and final cohort of patients in its ongoing Phase Ib trial of NSI-189 for major depressive disorder...Senesco Technologies Inc., of Bridgewater, N.J., completed the second cohort of its Phase Ib/IIa trial of SNS01-T. Two multiple myeloma patients and one diffuse large B-cell lymphoma patient have completed the study
Emergent BioSolutions Inc., of Rockville, Md., expanded the protocol for its ongoing Phase Ib, single-arm, open-label study (Protocol 16009) that is evaluating the safety and efficacy of TRU-016 in combination with rituximab in previously untreated patients with chronic lymphocytic leukemia (CLL
Trophos SA, of Marseille, France, said it started a Phase Ib study of olesoxime, a mitochondrial-targeted, cholesterol-like compound, in multiple sclerosis patients as a complementary therapy to interferon-beta
N30 Pharmaceuticals Inc., of Boulder, Colo., said it administered the first dose in its Phase Ib/IIa trial of N6002, a drug designed to conserve endogenous signaling molecule S-nitrosoglutathione, in patients with cystic fibrosis (CF
Protalex Inc., of Summit, N.J., said that following a planned interim safety review by a data safety monitoring committee, it will continue enrollment and dosing of patients in its Phase Ib trial of PRTX-100 in combination with methotrexate and leflunomide for rheumatoid arthritis
Silence Therapeutics plc, of London, said it received formal approval from German regulators for a Phase Ib/IIa combination trial testing Atu027, its anti-metastatic RNAi compound, in combination with gemcitabine in pancreatic cancer...The Phase Ib portion is expected to last for three months, with the Phase IIa portion expected to start in July of this year and end in July 2014
Shape Pharmaceuticals Inc., of Cambridge, Mass., said SHP-141, its topical histone deacetylase inhibitor in development for cutaneous T-cell lymphoma (CTCL), is being tested in a Phase Ib trial designed to evaluate escalating doses in patients with Stage Ia, Ib or IIa CTCL
Avaxia Biologics Inc., of Lexington, Mass., said the first patient was dosed in a Phase Ib study of AVX-470, its oral anti-TNF antibody, in ulcerative colitis
Data from the G-202 Phase Ib program in solid tumor patients showed the compound was well tolerated, with prolonged disease stabilization observed in several hepatocellular carcinoma patients who had previously progressed on sorafenib therapy
Cellceutix Corp., of Beverly, Mass., said it is planning a Phase Ib trial in Europe testing Kevetrin in combination with cytarabine in patients with acute myelogenous leukemia...The Phase Ib portion will enroll all patients with solid tumors, while the Phase IIa portion will enroll gastric and breast cancer patients
The 30-patient dose escalation trial evaluated the detailed pharmacokinetics of mibefradil administered four times a day and confirmed its safe dose levels for use in a Phase Ib trial
CytRx Corp., of Los Angeles, reported initial data from a Phase Ib trial evaluating the pharmacokinetics and safety of aldoxorubicin in patients with metastatic solid tumors who have either relapsed or not responded to standard treatment...The data from a randomized, double-blind, placebo-controlled Phase Ib multiple ascending dose study showed that PRM-151 was generally safe and well tolerated in patients with idiopathic pulmonary fibrosis