Hemaquest Pharmaceuticals Inc., of San Diego, has completed enrollment in a randomized, double-blind, placebo-controlled Phase IIb study of HQK-1001 in patients with sickle cell disease...The placebo-controlled, double-blind, randomized-withdrawal and enrollment enriched study, TRIG-05, officially began its enrollment period on May 31 and is expected to enroll 96 chronic migraine patients at trial sites located in Chile, with additional sites in Argentina expected to join in July

RXi Pharmaceuticals Corp., of Westborough, Mass., disclosed the unblinded results of the first of two placebo-controlled double-blind studies in volunteers with anti-scarring agent RXI-109, an sd-rxRNA compound that has been shown in vitro and in animals to reduce mRNA for connective tissue growth factor

Idera Pharmaceuticals Inc., of Cambridge, Mass., began dosing in a randomized, double-blind, placebo-controlled Phase II trial of IMO-8400 in patients with moderate to severe plaque psoriasis...The randomized, double-blind, placebo-controlled study will assess safety, tolerability and pharmacokinetic and pharmacodynamic profile of PE0139 in volunteers who have Type II diabetes

A total of 33 patients were randomized and completed both N05 and placebo periods in the double-blind, placebo-controlled, multicenter, crossover study

The 12-week, randomized, double-blind, parallel group study is evaluating the safety and tolerability of samatasvir and simeprevir in addition to antiviral activity endpoints, with a target enrollment of 90 treatment-naïve, noncirrhotic, genotype 1b or 4 HCV-infected patients who will be randomized equally across three treatment arms, receiving 50 mg, 100 mg or 150 mg samatasvir once daily for 12 weeks in combination with simeprevir plus ribavirin

The Phase IIb study is a double-blind, placebo-controlled, randomized, parallel group trial planned to be conducted at sites in the U.S. The study's co-primary endpoints are change in micturition frequency per 24 hours and change in urinary incontinence episodes per 24 hours, in each case from baseline to 12 weeks

Pending approval, the company intends to proceed with a randomized, double-blind, placebo-controlled, dose-escalating study to test the safety, tolerability and pharmacokinetics of ARC-520 in healthy volunteers

a reservoir of 10-mg dinoprostone in a vaginal insert (DVI) when used for labor induction in a randomized Phase III double-blind study of 1,358 women randomly assigned to receive either a single dose of MVDS (n = 678) or DVI (n = 680

The double-blind, multicenter study will assess safety and efficacy of the drug in 120 patients...The double-blind, randomized, placebo-controlled study is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of escalating doses of VBY-036 in healthy adults

The data from a randomized, double-blind, placebo-controlled Phase Ib multiple ascending dose study showed that PRM-151 was generally safe and well tolerated in patients with idiopathic pulmonary fibrosis

SONAR is a multinational, double-blind, placebo-controlled clinical study that is expected to enroll more than 4,000 patients with diabetic nephropathy

UCB SA, of Brussels, Belgium, said data from a double-blind, placebo-controlled study found that Neupro (rotigotine transdermal system) reduced total nocturnal systolic blood pressure (NSBP) elevations associated with periodic limb movements during sleep (PLMS) and total PLMS in patients with idiopathic moderate to severe restless legs syndrome (RLS)/Willis-Ekbom disease

The randomized, double-blind, placebo-controlled 11-week trial is expected to enroll about 180 treatment-seeking cocaine-dependent subjects at approximately 12 U.S

The NH004-3 clinical trial is a double-blind, placebo-controlled, randomized, crossover, multicenter study comparing NH004 and placebo thin films in Parkinson's disease patient complaining of sialorrhea

The double-blind, randomized, placebo-controlled study will enroll 21 participants with burn scars that restrict range of motion of jointed areas such as elbows, shoulders and fingers...The randomized, double-blind, placebo-controlled study (209AS208) evaluated the safety, tolerability and efficacy of arbaclofen in 150 ASD subjects, ages 5 to 21 years, with a particular focus on social function

The randomized, double-blind, parallel group trial is evaluating TC-1734 against donepezil (Aricept, Pfizer Inc.) in approximately 300 patients at sites predominantly in Eastern Europe and the U.S. The Alzheimer's Disease Assessment Scale-cognitive subscale and the Clinician Interview-Based Impression of Change Plus Caregiver Input, or CIBIC-(+), are co-primary endpoints, with the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory replacing CIBIC-(+) as a co-primary

The primary objective of the double-blind, randomized, single ascending dose study is to evaluate the safety and tolerability of rHIgM22 in subjects with MS...The primary endpoint of the randomized, double-blind, placebo-controlled trial is the effect of repeat oral dosing of the Cav2.2 selective blocker on the pain experienced in PHN after three weeks, compared with baseline

Ceregene Inc., of San Diego, reported top-line data from its double-blind, randomized, controlled Phase IIb study of CERE-120 (AAV-neurturin), a gene therapy designed to deliver the neurotrophic factor neurturin, for Parkinson's disease...The double-blind study enrolled 34 patients who received placebo or one of three different doses of LL-37

The 26-week, double-blind, randomized, parallel group, placebo-controlled trial will evaluate change in percent atheroma volume after 26 weeks of treatment, with safety and tolerability as secondary endpoints, as well as changes in ApoA-I, HDL-, HDL-subclasses and non-HDL lipid parameters...The company expects to report top-line results of the multicenter, randomized, double-blind, placebo-controlled, parallel group trial by year-end