The trial will consider a single dose of CMX001, 100 mg twice weekly, as opposed to the two dose structure used in the Phase II trial

Viralytics Ltd., of Sydney, Australia, said it finalized the clinical study report on the Phase I evaluation of Cavatak, administered intravenously to late-stage melanoma, prostate, breast or colorectal cancer patients, with results showing that the oncolytic virus-based drug candidate was well tolerated, with some evidence of stable disease despite most patients only receiving a single dose

The study tested two dose levels of the RSV F protein nanoparticle vaccine candidate with and without aluminum phosphate as an adjuvant and enrolled 330 women to receive either one or two intramuscular injections of a single-dose of vaccine or placebo, at study day 0 and day 28

Idera completed the escalating single dose and multiple dose parts of the Phase I trial

The open-label, dose escalation study will evaluate the safety and activity of single doses of TT-034 in patients with chronic HCV genotype 1 infection who failed previous treatments

Upsher-Smith Laboratories Inc., of Maple Grove, Minn., presented data at the American Academy of Neurology meeting in San Diego, supporting favorable tolerability and a predictable, consistent pharmacokinetic profile of USL255 at high doses following single-dose administration to healthy subjects

Acorda Therapeutics Inc., of Ardsley, N.Y., said data from a Phase I study showed that a single dose of 20-mg Diazepam Nasal Spray had comparable plasma bioavailability to 20 mg of diazepam rectal gel

The NX03-0040 prostate cancer clinical study of 150 men is testing low (2.5 mg) and high (15 mg) single doses of NX-1207 for the effect to eradicate or shrink low-grade localized prostate cancer tumors

The company has found in studies to date that a single dose of NX-1207 produces symptomatic improvements about double those of currently approved BPH therapies without sexual or cardiovascular side effects...Follow-up studies showed long-lasting benefit in a significant proportion of men who received a single dose, lasting up to 7.5 years

Acorda Therapeutics Inc., of Ardsley, N.Y., reported data from a Phase I dose-escalation study showing that a single dose of glial growth factor 2 (GGF2), a neuregulin peptide, in patients with heart failure was generally well tolerated up to 0.75 mg/kg, while higher doses might be associated with reversible hepatotoxic events...The company also will report Phase I data that a single dose of GGF2 in patients with symptomatic heard failure showed a trend toward improving left ventricular function

Biomarkers at both the gene and protein level showed that a single dose of CAT-1004 produced a 70 percent reduction in nuclear p65, a marker of NF-kB activation

Data from a Phase IIb trial evaluating the safety and efficacy of tuberculosis (TB) vaccine MVA85A showed that a single dose of the vaccine was not sufficient to confer statistically significant protection against TB or infection in infants vaccinated at birth with the Bacille Calmette-Guérin (BCG) vaccine

Boosting with a single dose of licensed inactivated H5N1 gave significantly higher rates of seroprotection than in placebo recipients only receiving a single dose of H5N1 vaccine (p < 0.001

The open-label study is enrolling patients with Stage IIIb and Stage IV disease, and the primary objectives include evaluating the safety of a single dose and repeat doses

Epirus Biopharmaceuticals Inc., of Boston, said lead asset BOW-015 achieved bioequivalence to Remicade (infliximab, Johnson & Johnson) in a single-dose comparator trial

Zogenix Inc., of San Diego, reported single-dose pharmacokinetic results from a Phase I trial testing Relday, a once-monthly subcutaneous formulation of risperidone for treating schizophrenia, showing that adverse events were generally mild to moderate and consistent with other risperidone products

NovaDigm Therapeutics Inc., of Grand Forks, N.D., published data from a Phase I study of its NDV-3 vaccine in Vaccine that showed a single dose of NDV-3 with alum adjuvant was safe, well tolerated and induced strong antibody and T-cell responses

Inovio Pharmaceuticals Inc., of Blue Bell, Pa., reported interim Phase I data showing that a single dose of its H1N1 universal SynCon flu vaccine followed with a dose of a seasonal flu vaccine generated protective immune responses in 40 percent of trial subjects, compared with a 20 percent response rate in elderly patients who received the seasonal flu vaccine alone

Single doses up to 7.5 mg were generally well tolerated, with no significant adverse events