Boehringer Ingelheim GmbH, of Ingelheim, Germany, reported data at the APASL Liver Week meeting in Singapore from the Phase IIb interferon-free SOUND-C3 trial testing faldaprevir and deleobuvir (BI 207127) plus ribavirin in treatment-naïve patients with genotype 1b hepatitis C virus

Hemaquest Pharmaceuticals Inc., of San Diego, has completed enrollment in a randomized, double-blind, placebo-controlled Phase IIb study of HQK-1001 in patients with sickle cell disease

The company plans to begin a Phase IIb study by the end of 2013

Targacept Inc., of Winston-Salem, N.C., started a Phase IIb study of TC-5214 as a treatment for overactive bladder (OAB...The Phase IIb study is a double-blind, placebo-controlled, randomized, parallel group trial planned to be conducted at sites in the U.S. The study's co-primary endpoints are change in micturition frequency per 24 hours and change in urinary incontinence episodes per 24 hours, in each case from baseline to 12 weeks

Based on the data, Helsinn is planning a Phase IIb study, expected to start in the second half of this year

Repros Therapeutics Inc., of The Woodlands, Texas, said the FDA recommended a Phase IIb study of Proellex-V, a product in development by for uterine fibroids, before proceeding to Phase III

Ceregene Inc., of San Diego, reported additional efficacy data from a secondary analysis of its Phase IIb study of CERE-120 (AAV-neurturin), a gene therapy product designed to deliver the neurotrophic factor neurturin to treat Parkinson's disease...Jennerex Biotherapeutics Inc., of San Francisco, and Transgene SA, of Strasbourg, France, said enrollment in the 120-patient TRAVERSE Phase IIb study testing Pexa-Vec (JX-594/TG6006, pexastimogene devacirepvec) for the treatment of advanced primary liver

The trial design was supported by promising data from a Phase IIb study in patients receiving bavituximab plus docetaxel...Tracon Pharmaceuticals Inc., of San Diego, said it initiated two randomized Phase IIb studies to evaluate TRC105 in combination with bevacizumab (Avastin) in metastatic kidney cancer and recurrent glioblastoma multiforme

Pexa-Vec is currently being evaluated in an international, randomized Phase IIb trial (TRAVERSE) in patients with advanced primary liver cancer who have failed sorafenib therapy

PharmaMar SA, of Madrid, a subsidiary of Zeltia SA, said it completed enrollment in its Phase IIb study testing PM01183 vs

The Phase IIb study allows for a head-to-head comparison of the commonly used chemotherapeutic agent doxorubicin with aldoxorubicin, CytRx's tumor-targeting doxorubicin conjugate...Data from the Phase IIb trial is expected in the second half of 2013

Seaside Therapeutics Inc., of Cambridge, Mass., said its Phase IIb trial evaluating arbaclofen (STX209) in core impairments of autism spectrum disorder (ASD) failed to show improvement on the primary endpoint of social withdrawal but demonstrated improvement on the clinical global impression of severity scale

Oxygen Biotherapeutics Inc., of Morrisville, N.C., said it initiated the second cohort of its Phase IIb trial of Oxycyte in patients with severe, nonpenetrating traumatic brain injury (TBI

Targacept Inc., of Winston-Salem, N.C., said it completed patient recruitment in the Phase IIb study of TC-1734, an alpha4beta2 neuronal nicotinic receptor, in mild-to-moderate Alzheimer's disease

Acucela Inc., of Seattle, said it started a Phase IIb/III trial of emixustat hydrochloride for geographic atrophy associated with dry age-related macular degeneration

Ceregene Inc., of San Diego, reported top-line data from its double-blind, randomized, controlled Phase IIb study of CERE-120 (AAV-neurturin), a gene therapy designed to deliver the neurotrophic factor neurturin, for Parkinson's disease

Resverlogix Corp., of Calgary, completed dosing in a Phase IIb (ASSURE) trial of RVX-208 in patients with low HDL and ApoA-1 at high risk for cardiovascular events...Targacept Inc., of Winston-Salem, N.C., said it completed patient recruitment in the Phase IIb study of TC-5619 to treat negative symptoms and cognitive dysfunction in schizophrenia

MRI assessments were performed as a quantifiable and objective measure of SMF volume and thickness in the multicenter, randomized, double-blind, placebo-controlled Phase IIb study (ATX-101-09-15), which also demonstrated positive results based on validated clinician- and patient-reported outcome measures

Sorbent Therapeutics Inc., of Sunnyvale, Calif., began dosing patients in a Phase IIb trial (STEPWISE) of CLP-1001 in congestive heart failure