Pexa-Vec is currently being evaluated in an international, randomized Phase IIb trial (TRAVERSE) in patients with advanced primary liver cancer who have failed sorafenib therapy

CytRx Corp., of Los Angeles, said the independent data safety monitoring committee overseeing the company's international Phase IIb trial with aldoxorubicin as a first-line treatment for patients with late-stage metastatic soft tissue sarcoma has recommended conducting the clinical trial through completion...Data from the Phase IIb trial is expected in the second half of 2013

Seaside Therapeutics Inc., of Cambridge, Mass., said its Phase IIb trial evaluating arbaclofen (STX209) in core impairments of autism spectrum disorder (ASD) failed to show improvement on the primary endpoint of social withdrawal but demonstrated improvement on the clinical global impression of severity scale

Oxygen Biotherapeutics Inc., of Morrisville, N.C., said it initiated the second cohort of its Phase IIb trial of Oxycyte in patients with severe, nonpenetrating traumatic brain injury (TBI

Sorbent Therapeutics Inc., of Sunnyvale, Calif., began dosing patients in a Phase IIb trial (STEPWISE) of CLP-1001 in congestive heart failure

Ltd., of Seoul, South Korea, said they completed the Phase IIb trial of Tarafenacin, in development for treating overactive bladder syndrome

NovaBay Pharmaceuticals Inc., of Emeryville, Calif., enrolled first patients in Brazil into its global Phase IIb trial, BAYnovation

Aastrom Biosciences Inc., of Ann Arbor, Mich., enrolled its first patients in a Phase IIb trial of ixCELL-DCM to assess safety and efficacy of ixmyelocel-T in advanced heart failure that is caused by ischemic dilated cardiomyopathy...Biogen Idec Inc., of Weston, Mass., said results of a daclizumab high-yield process (DAC HYP) Phase IIb trial were published online in The Lancet

CureVac GmbH, of Tubingen, Germany, said it started a Phase IIb trial testing RNActive cancer vaccine CV9104 in patients with castration-resistant prostate cancer...Neurocrine Biosciences Inc., of San Diego, said it started a Phase IIb trial testing elagolix, an oral gonadotropin-releasing hormone antagonist, in uterine fibroids

Poxel SA, of Lyon, France, said it started a Phase IIb trial of imeglimin in Type II diabetes

Tobira Therapeutics Inc., of South San Francisco, reported results from a Phase IIb trial of cenicriviroc, a once-daily dual CCR5/CCR2 inhibitor, at the Conference on Retroviruses and Opportunistic Infections in Atlanta

Vintafolide and etarfolatide are currently being evaluated in a Phase III randomized, double-blind trial for platinum-resistant ovarian cancer (PROCEED trial) and a Phase IIb trial in patients with NSCLC (TARGET trial...Data from a Phase IIB trial were presented last week at the International Society for the Study of Women's Sexual Health conference in New Orleans

Data from a Phase IIb trial evaluating the safety and efficacy of tuberculosis (TB) vaccine MVA85A showed that a single dose of the vaccine was not sufficient to confer statistically significant protection against TB or infection in infants vaccinated at birth with the Bacille Calmette-Guérin (BCG) vaccine

CytRx Corp., of Los Angeles, said a data safety monitoring committee recommended continuing a Phase IIb trial of tamibarotene with chemotherapy in non-small-cell lung cancer

Molecular Partners licensed rights to MP0112 to Allergan Inc., of Irvine, Calif., which is testing the drug in a Phase IIb trial in exudative age-related macular degeneration. (See BioWorld Today, May 11, 2011

Synergy Pharmaceuticals Inc., of New York, said dosing has commenced in a Phase IIb trial of plecanatide to treat patients with constipation-predominant irritable bowel syndrome (IBS-C

Neurocrine Biosciences Inc., of San Diego, said it started a Phase IIb trial (Kinect 2 Study) of its vesicular monoamine transporter 2 compound, NBI-98854

Pharmalink AB, of Stockholm, Sweden, began a Phase IIb trial of Nefecon (Nefigan) for IgA nephropathy

Celladon Corp., of San Diego, dosed its first patient in Europe in a Phase IIb trial of Mydicar for heart failure