Portola Pharmaceuticals Inc., of South San Francisco, Calif., reported safety and efficacy data from a Phase II proof-of-concept study of PRT4445 of Eliquis (apixaban) in healthy volunteers
GTx Inc., of Memphis, Tenn., said it is starting a proof-of-concept Phase II study to evaluate enobosarm (GTx-024), a selective androgen receptor modulator, in metastatic breast cancer
Convergence Pharmaceuticals Ltd., of Cambridge, England, started a Phase II proof-of-concept study with CNV2197944 in pain associated with post-herpetic neuralgia (PHN
Galleon Pharmaceuticals Inc., of Horsham, Pa., said its lead drug, GAL-021, was shown to regulate and protect respiratory drive from drug-induced respiratory depression in a proof-of-concept study
Summit plc, of Oxford, UK, said it plans to initiate a two-part proof-of-concept trial with lead candidate SMT-C1100 in Duchenne's muscular dystrophy (DMD
Soricimed Biopharma Inc., of Toronto, reported results from molecular imaging investigation that provided proof of concept for the use of SOR peptides to detect and potentially treat ovarian, breast, thyroid, prostate and colon cancer
Designed to work as a gap junction modifier, the drug has completed Phase I testing, and the planned Phase IIa proof-of-concept trial is expected to include several hundred patients with a heart attack
The company also reported results from proof-of-concept studies in acute liver injury, showing that its new lipid formulation, DBTC, is effective at delivering RNAi treatments to liver tissues
The Phase I proof-of-concept trial ARMOR1 , part of the ARMOR (Androgen Receptor Modulation Optimized for Response), enrolled 49 patients and was a dose-finding study to evaluate escalating dose levels of galeterone
Synthetic Biologics Inc., of Rockville, Md., said its flupirtine sublicensee, Meda AB, of Goteborg, Sweden, received a green light from the FDA to conduct a Phase II proof-of-concept study for the treatment of fibromyalgia, as reported in Meda's 2012 year-end report
The results from a Phase II study established human proof-of-concept that co-administration of AT2220 just prior to infusing ERT (Myozyme/Lumizyme, or rhGAA enzymes) increases GAA enzyme activity in muscle tissue compared to ERT alone
Data also showed that the conjugated compound was absorbed following oral administration and metabolized to its active components intracellularly, providing proof of concept for the SMART Linker platform
Stratatech Corp., of Madison, Wis., reported top-line data from a proof-of-concept trial testing StrataGraft, a universal human skin substitute in development for treating severe burns
analyst Simos Simeonidis wrote, "This is the first proof-of-concept (POC) trial run by Servier in a CV indication and we view it as a very interesting one, since if treatment with gevokizumab were to have an impact, even a very slight one, on the size or the inflammatory composition of atherosclerotic plaque after just three months of treatment, the medical and commercial implications could, of course, be very significant
A Phase Ib study of ProHema achieved its primary objective of demonstrating safety and tolerability and established early clinical proof of concept, including trends of accelerated neutrophil recovery, improved 100-day survival and low rates of graft-vs.-host disease
Portola Pharmaceuticals Inc., of South San Francisco, Calif., reported safety and efficacy data from a Phase II proof-of-concept study of PRT4445 of Eliquis (apixaban) in healthy volunteers