The primary endpoint is change in quality of life and physical functioning, including the six-minute walk test, body weight, Kansas City Cardiomyopahty Questionnaire, NT-pro BNP and time to first heart failure hospitalization, decongestion therapy or death
The study is designed to demonstrate a reversal of weight loss following treatment with MT-102, but also will examine improvement in functional ability and quality of life by a battery of previously validated instruments
The objectives are to measure progression-free survival and overall survival, while safety parameters, quality-of-life impact, manufacturing quality and additional laboratory assessments also will be investigated
The 12-month trial will measure improvement in visual function as the primary endpoint, with secondary outcome measurements assessing neurologic and neuromuscular function, glutathione biomarkers, quality of life and safety
The trial also will evaluate spontaneous bowel movements, daily abdominal pain, discomfort and bloating scores as well as the impact of plecanatide on disease-specific quality-of-life measures
The primary endpoint is the normalized number of angioedema attacks recorded during each treatment period, while secondary endpoints will assess attack severity, quality-of-life parameters and number of angioedema attacks requiring acute treatment
The study will evaluate the effects of once-daily dosing of AC-1204 for 26 weeks on cognition, pharmacokinetic measures, activities of daily living, resource utilization and quality of life among subjects with mild-to-moderate AD with a primary endpoint tagged to the effects of AC-1204 on memory and cognition as measured by the Alzheimer's Disease Assessment Scale-cognitive subscale after 26 weeks among both carriers and noncarriers of the epsilon 4 variant of the gene apolipoprotein E
That study will explore TSC's effects on tumor regrowth, patient quality of life and overall survival in GBM patients when dosed in conjunction with conventional radiation therapy
Immunomedics Inc., of Morris Plains, N.J., said patients receiving epratuzumab reported clinically meaningful improvements in health-related quality of life (HRQoL) that were sustained over about four years of treatment
Secondary endpoints include safety, overall survival, complete hematologic response CR, progression-free survival, duration of response and quality of life
A second poster will present data indicating that patients who responded to treatment significantly increased three separate measures of quality of life, regardless of age
Started in March, the Eslicarbazepine acetate in Partial-Onset Seizures study is intended to enroll about 800 patients, with a primary endpoint of six-month retention rate and other assessments, including seizure frequency, adverse events and quality of life
Boehringer Ingelheim Pharmaceuticals Inc., of Ridgefield, Conn., part of Boehringer Ingelheim GmbH, reported new patient-reported health-related outcomes for its investigational oncology compound afatinib, including lung cancer-related symptoms and quality of life
The primary endpoint is the annual rate of decline in forced vital capacity, while secondary endpoints include health-related quality of life, exacerbations, respiratory mortality, overall survival and on-treatment survival
Secondary endpoints include change from baseline in quality of life, time to first acute exacerbation, respiratory mortality, overall survival and on-treatment survival
The primary endpoint is change in quality of life and physical functioning, including the six-minute walk test, body weight, Kansas City Cardiomyopahty Questionnaire, NT-pro BNP and time to first heart failure hospitalization, decongestion therapy or death