The open-label, dose-escalation trial was conducted in 52 men with hormone-refractory prostate cancer that had progressed despite prior treatment with taxane-based chemotherapy regimens
Dose escalation will continue as planned to the 1,200-mg dose cohort...Following successful completion of the dose-escalation component of the study, an additional expansion cohort may be added at the highest dose of 1,200 mg
Vaximm AG, of Basel, Switzerland, said top-line data from its Phase I/II dose-escalation study of oral cancer vaccine VXM01 met key safety and tolerability endpoints
The safety and dose-escalation trial will test GL-ONC1 as administered intrapleurally as a single-agent therapy...Both are open-label, dose-escalation trials, one in B-cell acute lymphoblastic leukemia and the other in B-cell non-Hodgkin's lymphomas, and both are designed to assess the safety and antitumor activity of the CD19-targeted drug
The two-part study will feature a dose-escalation portion testing the drugs in combination as a second-line treatment, while the second part will be an open-label, randomized study to determine whether treatment with dalantercept plus axitinib can prolong progression-free survival (PFS) vs...The dose-escalation study will evaluate safety, tolerability and efficacy as determined by RECIST criteria and the company's cancer stem cell biomarkers
Thirty-five patents with relapsed or refractory disease after at least two previous regimens with other drugs were included in the dose escalation study
The 30-patient dose escalation trial evaluated the detailed pharmacokinetics of mibefradil administered four times a day and confirmed its safe dose levels for use in a Phase Ib trial
Alnylam expects to initiate the dose-escalation study early this year, enrolling up to 40 healthy volunteers to evaluate safety and tolerability with a secondary assessment of clinical activity measured by serum TTR levels
NewLink Genetics Corp., of Ames, Iowa, published results of a Phase I dose-escalation study of HyperAcute Prostate Cancer Immunotherapy in the Journal of Immunotherapy
The multicenter trial will enroll up to 30 patients in the Phase I dose escalation component and up to an additional 30 patients, stratified by B-cell malignancy subtype, once the optimal dose is determined
Patients in the dose-escalation study will receive intradermal injections of RXI-109, a self-delivering RNAi compound designed to reduce CTGF expression, on three occasions over two weeks
The dose-escalation study enrolled 60 HIV-uninfected adults and tested doses of the vaccine, which comprises an rVSV vector expressing the HIV-1 gag protein, administered by intramuscular injection
The study is composed of two parts: The first will involve sequential dose escalation for assessing dose response and pharmacokinetics/pharmacodynamics, while the second will serve as a confirmatory study to confirm the efficacy and safety of the drug
Coronado Biosciences Inc., of Burlington, Mass., said it started a Phase I/II dose-escalation trial of allogeneic natural killer (NK) cells activated by its CNDO-109 in patients in first complete remission from acute myeloid leukemia (AML) and who are deemed high risk for relapse
The open-label, dose-escalation trial was conducted in 52 men with hormone-refractory prostate cancer that had progressed despite prior treatment with taxane-based chemotherapy regimens