Ltd., of Seoul, South Korea, said they completed the Phase IIb trial of Tarafenacin, in development for treating overactive bladder syndrome...Photocure ASA, of Oslo, Norway, reported final results from its Phase IIb study of Cevira in patients with human papillomavirus (HPV)-related disease of the cervix, showing that the drug-delivery device demonstrated significant and sustained efficacy in the eradication of oncogenic HPV infections and precancerous lesions in CIN2 patients

NovaBay Pharmaceuticals Inc., of Emeryville, Calif., enrolled first patients in Brazil into its global Phase IIb trial, BAYnovation

Sarepta Therapeutics Inc., of Cambridge, Mass., reported updated data from Study 202, a Phase IIb open-label extension study of eteplirsen in Duchenne's muscular dystrophy (DMD

Aastrom Biosciences Inc., of Ann Arbor, Mich., enrolled its first patients in a Phase IIb trial of ixCELL-DCM to assess safety and efficacy of ixmyelocel-T in advanced heart failure that is caused by ischemic dilated cardiomyopathy...Biogen Idec Inc., of Weston, Mass., said results of a daclizumab high-yield process (DAC HYP) Phase IIb trial were published online in The Lancet

CureVac GmbH, of Tubingen, Germany, said it started a Phase IIb trial testing RNActive cancer vaccine CV9104 in patients with castration-resistant prostate cancer...Neurocrine Biosciences Inc., of San Diego, said it started a Phase IIb trial testing elagolix, an oral gonadotropin-releasing hormone antagonist, in uterine fibroids

Biothera Inc., of Eagen, Minn., said it completed enrollment of its 90-patient Phase IIb study testing Imprime PGG, Avastin (bevacizumab, Roche AG) and two chemotherapeutic drugs in non-small-cell lung cancer

Lithera Inc., of San Diego, said the first patient was treated with LIPO-202 (salmeterol xinafoate for injection) in its 500-patient Phase IIb RESET trial

Poxel SA, of Lyon, France, said it started a Phase IIb trial of imeglimin in Type II diabetes

Tobira Therapeutics Inc., of South San Francisco, reported results from a Phase IIb trial of cenicriviroc, a once-daily dual CCR5/CCR2 inhibitor, at the Conference on Retroviruses and Opportunistic Infections in Atlanta

Vintafolide and etarfolatide are currently being evaluated in a Phase III randomized, double-blind trial for platinum-resistant ovarian cancer (PROCEED trial) and a Phase IIb trial in patients with NSCLC (TARGET trial...Data from a Phase IIB trial were presented last week at the International Society for the Study of Women's Sexual Health conference in New Orleans

CytRx Corp., of Los Angeles, said it completed enrollment of 140 patients in its Phase IIb study testing oral retinoid compound tamibarotene in combination with chemotherapeutic agents as a first-line treatment in advanced non-small-cell lung cancer

NovaBay Pharmaceuticals Inc., of Emeryville, Calif., said partner Galderma SA, of Lausanne, Switzerland, started the South African arm of its Phase IIb study testing a topical formulation of NVC-422 for the treatment of impetigo

Data from a Phase IIb trial evaluating the safety and efficacy of tuberculosis (TB) vaccine MVA85A showed that a single dose of the vaccine was not sufficient to confer statistically significant protection against TB or infection in infants vaccinated at birth with the Bacille Calmette-Guérin (BCG) vaccine...MVA85A also is being investigated in a Phase IIb study in HIV-positive individuals in Senegal and South Africa, a Phase IIa study in infants born to HIV-positive mothers in South Africa and

CytRx Corp., of Los Angeles, said a data safety monitoring committee recommended continuing a Phase IIb trial of tamibarotene with chemotherapy in non-small-cell lung cancer...Vanda Pharmaceuticals Inc., of Washington, said top-line data from its Phase IIb/III study, dubbed MAGELLAN, testing tasimelteon as a monotherapy in major depressive disorder (MDD) did not meet the primary endpoint of change from baseline in the Hamilton Depression Scale after eight weeks of treatment compared to placebo

signed a nonbinding letter of intent to collaborate on the initial Phase IIb portion of the trial

Molecular Partners licensed rights to MP0112 to Allergan Inc., of Irvine, Calif., which is testing the drug in a Phase IIb trial in exudative age-related macular degeneration. (See BioWorld Today, May 11, 2011

Cytos Biotechnology Ltd., of Zurich, Switzerland, said a technical issue was identified with the rubber stoppers used to close the injection vials containing clinical trial material for its Phase IIb study testing lead candidate CYT003 in allergic asthma

CoDa Therapeutics Inc., of San Diego, reported Phase IIb data showing that Nexagon in patients with chronic venous leg ulcers was found to be safe and produced an increase in complete healing in the vehicle-controlled trial

Edison Pharmaceuticals Inc., of Mountain View, Calif., said it started a Phase IIb study testing EPI-743 in patients with Friedreich's ataxia