Memory Pharmaceuticals Corp., of Montvale, N.J., reported positive top-line data from its Phase IIa trial of MEM 3454, a nicotinic alpha-7 receptor partial agonist, in 80 Alzheimer's disease patients over an eight-week treatment period
The trial has progressed ahead of schedule and is expected to be the first of Allon's three Phase II efficacy trials to report top-line data, with results expected in the first quarter of next year
The randomized, double-blind, placebo-controlled trial, known as MEND-CABG II, completed enrollment two months ahead of schedule, and top-line data are expected early next year
Evotec AG, of Hamburg, Germany, said results from its first Phase II trial of EVT 201 in patients with primary insomnia showed that all endpoints achieved an even higher level of statistical significance than top-line data in June indicated
Protox Therapeutics Inc., of Vancouver, British Columbia, released top-line data from a 24-patient Phase I trial of proaerolysin-based PRX302 in localized, recurrent prostate cancer refractory to radiation treatment
Top-line data are expected in the summer of 2008 for the primary endpoint of change in total lean body mass and secondary endpoints including functional performance and safety
Data released last month showed the clinical rate for cethromycin, a ketolide antibiotic, was 91.5 percent, lower than in the Biaxin arm but not in a statistically significant manner (p=0.0775). (See BioWorld Today, June 22, 2007.) The company expects to release top-line data on a second pivotal Phase III trial in September
Advanced Magnetics Inc., of Cambridge, Mass., said it expects to announce top-line data this summer from its fourth and final Phase III trial of ferumoxytol as an intravenous iron replacement in chronic kidney disease
Opexa Therapeutics Inc., of The Woodlands, Texas, disclosed positive top-line data in an open-label Phase I/II extension trial of the T-cell vaccine, Tovaxin for multiple sclerosis
placebo in patients with generalized anxiety disorder, though top-line data reported in September showed the trial did not meet its primary endpoint of a change from baseline in the Hamilton Rating Scale for Anxiety
Opexa Therapeutics Inc., of The Woodlands, Texas, disclosed positive top-line data from an open-label Phase I/II dose-escalation trial of the T-cell vaccine, Tovaxin, for multiple sclerosis
Inflazyme Pharmaceuticals Ltd., of Vancouver, British Columbia, announced that top-line data from a Phase IIb trial of asthma drug IPL512,602 demonstrated no statistically significant differences between drug and placebo groups due to a high response rate in both groups
The company also is finishing up a 40-patient Phase II study of Lymphoseek in breast cancer and melanoma and expects to report top-line data later this quarter
AnorMED Inc., of Vancouver, British Columbia, completed enrollment in the second pivotal Phase III clinical trial evaluating its proprietary product Mozobil in cancer patients, and said it is on track to meet its schedule of releasing top-line data from both Phase III trials in the first half of 2007...Top-line data were presented at the annual meeting of the North American Association for the Study of Obesity in Boston
Memory Pharmaceuticals Corp., of Montvale, N.J., reported positive top-line data from its Phase IIa trial of MEM 3454, a nicotinic alpha-7 receptor partial agonist, in 80 Alzheimer's disease patients over an eight-week treatment period