Novavax Inc., of Rockville, Md., said it started enrollment in a Phase I dose-ranging trial testing its respiratory syncytial virus (RSV) vaccine candidate in healthy elderly adults...Tarsa Therapeutics Inc., of Philadelphia, said its Phase II trial testing oral recombinant salmon calcitonin in the prevention of postmenopausal osteoporosis yielded statistically significant, clinically relevant improvements in bone mineral density (BMD) at the lumbar spine

Eli Lilly and Co., of Indianapolis, said the Phase III REGARD trial testing ramucirumab in patients with metastatic gastric cancer met its primary endpoint of improved overall survival and also showed prolonged progression-free survival

Fab'entech, of Lyon, France, said it is launching a Phase I trial testing a its polyclonal immunoglobulin product against the H5N1 avian flu virus

Cleveland BioLabs Inc., of Buffalo, N.Y., and Incuron LLC, a joint venture between the firm and Bioprocess Capital Ventures, said the first patient was dosed in a Phase I single-agent, dose-escalation trial testing the oral formulation of CBL0137 in subjects with advanced solid tumors who are resistant or refractory to standard of care...It's the second Phase III trial testing algenpantucel-L in pancreatic cancer

BioLineRx Ltd., of Jerusalem, said a recent analysis of data from its Phase IIb EAGLE trial testing orally available GABA-enhanced antipsychotic BL-1020 in schizophrenia indicated that the drug demonstrated a significant increase in efficacy at improving cognitive impairment associated with the condition, as compared to the original analysis of the study

OncoMed Pharmaceuticals Inc., of Redwood City, Calif., said it started a Phase Ib/II trial testing anti-Notch2/3 antibody OMP-59R4 in combination with gemcitabine in first-line advanced pancreatic cancer patients

Inc., reported data from two Phase III trials testing low-dose mesylate salt of paroxetine (LDMP) 7.5 mg/day in moderate to severe vasomotor symptoms (VMS) associated with menopause

Boehringer Ingelheim GmbH, of Ingelheim, Germany, said it completed enrollment in two Phase III trials testing nintedanib (BIBF 1120) in patients with idiopathic pulmonary fibrosis

Noxxon started a previous Phase IIa trial testing NOX-A12 in chronic lymphocytic leukemia...Resverlogix Corp., of Calgary, Alberta, said it completed enrollment in the Phase IIb ASSURE trial testing the ability of RVX-208, its BET protein inhibitor, to regress atherosclerotic disease vs

ViroPharma Inc., of Exton, Pa., and Halozyme Therapeutics Inc., of San Diego, said the FDA provided guidance enabling ViroPharma to resume clinical trials testing the subcutaneous administration of hereditary angioedema drug Cinryze (C1 esterase inhibitor [human]) in combination with Halozyme's recombinant human hyaluronidase (rHuPH20

Biogen Idec Inc., of Weston, Mass., said detailed results from pivotal trials testing oral BG-12 (dimethyl fumarate) in multiple sclerosis (MS) were published in the New England Journal of Medicine...and Europe to proceed with a Phase I/II trial testing DCVax-Direct for all types of solid tumors

Advanced Accelerator Applications SA, of Saint Genis Pouilly, France, said it started a Phase III trial testing the effect of theranostic drug Lutathera in patients with inoperable progressive midgut carcinoid...Imprimis Pharmaceuticals Inc., of Solana Beach, Calif., said it started a clinical trial testing Impracor, a topical cream designed to deliver ketoprofen

e-Therapeutics plc, of Oxford, UK, said it started a second Phase I trial testing cancer drug ETS2101, a drug designed to promote apoptosis

Acadia Pharmaceuticals Inc., of San Diego, said it completed enrollment in an ongoing pivotal Phase III trial testing pimavanserin in patients with Parkinson's disease psychosis...The Phase II trial testing R333 will enroll more than 50 patients with active discoid skin lesions from DLE or systemic lupus erthyematosus, and the primary endpoints will be the measurements of each person's decrease in the total combined Erythema and Scaling Score of all treated lesions from baseline to day 28

Avanir Pharmaceuticals Inc., of Aliso Viejo, Calif., said it enrolled the first patient in AVR-131, a Phase II trial testing AVP-923 for the treatment of agitation in patients with Alzheimer's disease...The RECAP study is an ongoing open-label extension trial testing long-term administration of Esbriet in patients who completed the CAPACITY program

Eli Lilly and Co., of Indianapolis, said it is stopping ongoing trials testing promaglumetad methionil, also known as mGlu2/3, for the treatment of schizophrenia, after a recently conducted independent futility analysis concluded that the second of two pivotal studies was unlikely to be positive in its primary efficacy endpoint if enrolled to completion

Celladon Corp., of San Diego, said it dosed the first patient in a Phase IIb trial testing Mydicar, a genetically targeted enzyme replacement therapy intended to restore levels of SERCA2a, a regulator of calcium cycling in the heart and cardiac contractility...The first study is expected to be a Phase I/II trial testing the drug in menopausal women not receiving hormone replacement therapy

Pacific Therapeutics Ltd., of Vancouver, British Columbia, said it completed enrollment and initial dosing in its first clinical trial testing PTL-202 in healthy volunteers

Advanced Cell Technology Inc., of Marlborough, Mass., added Scotland's NHS Lothian as a site for its Phase I/II trial testing retinal pigment epithelial cells derived from human embryonic stem cells in Stargardt's macular dystrophy