In April, the company announced that dosing at the 9 mg level had begun in Canadian trial sites under a Canadian clinical trial application

Advanced Viral Research Corp., of Yonkers, N.Y., said Health Canada's Therapeutic Products Division approved a clinical trial application to start studies of AVR118 in patients with histologically confirmed malignancies who present with clinically demonstrable anorexia or anorexia-cachexia syndrome

CytRx said the results support the use of arimoclomol in future clinical trials, including its Phase IIb trial in amyotrophic lateral sclerosis, at doses up to sixfold higher than used in previous Phase IIa trials for ALS

The initial clinical trial results are expected by the end of this year or early 2008...In the one-year, eight-subject extension clinical trial of relapsing remitting and secondary progressive subjects, Tovaxin therapy was shown to be safe and effective

Three doses of AZ-104 (1.25 mg, 2.5 mg and 5 mg) will be evaluated against placebo in the clinical trial

In May NicOx halted the development of another drug candidate, NCX 1000, which was undergoing a Phase IIa clinical trial for the treatment of portal hypertension and was being co-developed with Axcan Pharma, of Mont-Saint-Hilaire, Quebec...StemCells Inc., of Palo Alto, Calif., said the Phase I clinical trial of its proprietary HuCNS-SC product candidate (purified human neural stem cells) has completed enrollment of the low-dose cohort and will proceed to the high-dose cohort

Living Cell Technologies Ltd., of Melbourne, Australia, said it successfully dosed the first patient in a Phase I/IIa clinical trial in Moscow using its DiabeCell pig pancreatic cell product to treat Type I diabetes

Critical Therapeutics Inc., of Lexington, Mass., said data from a pivotal Phase III clinical trial of Zyflo CR (zileuton) extended-release tablets were published in the June 2007 issue of the Journal of Asthma

NeurogesX Inc., of San Carlos, Calif., has completed enrollment in study C117, a second Phase III clinical trial of its lead product candidate NGX-4010, for the treatment of postherpetic neuralgia...Neuro-Hitech Inc., of New York, said its Phase II clinical trial of Huperzine A is fully enrolled, with 210 subjects being evaluated at 35 U.S

and Canadian clinical trials that demonstrated that fusion rates for GEM OS-treated patients appeared to be at least comparable to patients treated with autograft taken from elsewhere in the patient's own body, but without the donor site pain and potential complications of harvesting autograft...Vical Inc., of Chicago, said interim data on 19 subjects from an ongoing Phase I clinical trial demonstrated that intratumoral delivery of plasmid DNA encoding interleukin-2 into melanoma tumors, followed

Oncolytics Biotech Inc., of Calgary, Alberta, disclosed positive data from its U.S. Phase I clinical trial examining the systemic administration of Reolysin, a formulation of the human reovirus, in patients with advanced cancers

Acorda Therapeutics Inc., of Hawthorne, N.Y., presented a meta-analysis of data on 501 multiple sclerosis patients from two clinical trials of Fampridine-SR...Epeius Biotechnologies Corp., of San Marino, Calif., expanded ongoing clinical trials of Rexin-G to include patients with breast cancer and all types of sarcomas who have failed standard chemotherapy

Amarillo Biosciences Inc., of Amarillo, Texas, said Taiwan-based CytoPharm Inc., its partner in Taiwan and China, engaged a clinical research organization for a clinical trial in 152 chronic hepatitis C patients...About 45 clinical trial sites worldwide are expected to participate in the study

Pipex Pharmaceuticals Inc., of Ann Arbor, Mich., presented the results of an open-label phase I/II clinical trial of Coprexa (oral tetrathiomolybdate) for the treatment of refractory idiopathic pulmonary fibrosis at the American Thoracic Society Annual Meeting in San Francisco...Viventia Biotech Inc., of Toronto, reported final data from its recently completed dose escalation Phase I/II clinical trial of Vicinium in patients with high-risk, non-invasive bladder cancer

It is in Phase IIb clinical trials for both BPH and prostate cancer...The Phase I clinical trial is designed to assess the safety, tolerability and pharmacokinetics of the compound

Inovio Biomedical Corp., of San Diego, announced that the first data from clinical trials of a DNA vaccine delivered using Inovio's electroporation approach were presented at the 3rd International Conference on DNA Vaccines in Malaga, Spain...Limerick NeuroSciences Inc., of South San Francisco, initiated its first company-sponsored, Phase I clinical trial of LNS 5310, its lead candidate based on a strategy of chemically modulating the bioavailability of existing drugs to reduce their neurotoxicity

This final Phase II clinical trial was designed to assess thoroughly the positive safety and efficacy observations made in patients treated with Multikine in CEL-SCI's early Phase II studies

Avant Immunotherapeutics Inc., of Needham, Mass., reported positive preliminary results from a double-blind, placebo-controlled Phase I/II dose-escalating clinical trial of its typhoid fever vaccine candidate, Ty800, in healthy volunteers

The company expects to initiate its Phase II maximal tolerated dose clinical trial for BL-1020 by the end of June...In addition, the company reported the completion of the Phase IIb clinical trial with CF101 for the treatment of rheumatoid arthritis