Advanced Magnetics Inc., of Cambridge, Mass., said it expects to announce top-line data this summer from its fourth and final Phase III trial of ferumoxytol as an intravenous iron replacement in chronic kidney disease
Molecular Insight expects to report top-line data from this trial in the second half of 2008...Neurogen Corp., of Branford, Conn., announced positive top-line results from two dose-ranging Phase IIb trials in chronic insomnia patients with NG2-73, an alpha-3 preferring GABA(A) partial agonist
Corcept Therapeutics, of Menlo Park, Calif., said top line results from a proof of concept study indicate a statistically significant reduction in weight gain in subjects who took olanzapine plus Corlux compared to those who took olanzapine alone...Opexa Therapeutics Inc., of The Woodlands, Texas, disclosed positive top-line data in an open-label Phase I/II extension trial of the T-cell vaccine, Tovaxin for multiple sclerosis
placebo in patients with generalized anxiety disorder, though top-line data reported in September showed the trial did not meet its primary endpoint of a change from baseline in the Hamilton Rating Scale for Anxiety
Repros Therapeutics Inc., of The Woodlands, Texas, released top-line findings from its six-month study of Proellex in endometriosis, demonstrating that treatment with 50 mg of the product reduces both the duration and intensity of pain more effectively than 12.5-mg or 25-mg doses and is significantly better than Lucrin/Lupron (leuprolide, Abbott Laboratories) in reducing the number of days of pain over the course of the study
Human Genome Sciences Inc., of Rockville, Md., reported top-line 24-week follow-up data from a Phase IIb trial comparing the combination of the long-acting interferon Albuferon (albinterferon alfa-2b) and ribavirin to Pegasys (peginterferon alfa-2a, F. Hoffmann-La Roche Ltd.) in treatment-naïve, genotype 1 chronic hepatitis C virus (HCV
Top-line data from the first of two pivotal, post-surgical Phase III trials of Javelin's Rylomine is anticipated this summer...Repros Therapeutics Inc., of The Woodlands, Texas, said top-line Phase III data indicated that oral Androxal is not inferior to Androgel (testosterone gel, Solvay SA) in secondary hypogonadism
Evotec AG, of Hamburg, Germany, reported positive top-line results from its first Phase II trial of EVT 201, a partial positive allosteric modulator of the GABAA receptor complex, in primary chronic insomnia
Peregrine Pharmaceuticals Inc., of Tustin, Calif., reported positive top-line results of its Phase Ib trial of bavituximab in combination with chemotherapy in advanced cancer patients with metastatic disease who had failed prior therapy
Those end-of-study results reflect an additional 17 months of data collection beyond the top-line results reported in March 2006, in which Oncophage missed its primary endpoints for the entire trial population of 728 kidney cancer patients
AlphaRx Inc., of Markham, Ontario, and Proprius Pharmaceuticals Inc., of San Diego, said top-line results from an exploratory Phase II trial of Indaflex 2.5 percent topical indomethacin cream in osteoarthritis of the knee did not meet the primary endpoints
Anesiva Inc., of South San Francisco, said top-line Phase II data of 4975 in postsurgical pain associated with total knee replacement demonstrated a significant reduction in pain on first ambulation on first day postsurgery and reduction in "pain right now" and "worst pain in past 24 hours" on Brief Pain Inventory at two weeks postsurgery...DeCODE genetics Inc., of Reykjavik, Iceland, reported positive, top-line Phase I results showing that DG051 reduced leukotriene B4 production in a dose
Cobalis Corp., of Irvine, Calif., said its independent contract research organization will need more time to combine Cobalis' three locked databases into a single database before unblinding and conducting the statistical analysis required to generate top-line results for Cobalis' twin pivotal Phase III Clinical Trials of PreHistin in seasonal allergic rhinitis...The company anticipates reporting its top-line results later in May
Opexa Therapeutics Inc., of The Woodlands, Texas, disclosed positive top-line data from an open-label Phase I/II dose-escalation trial of the T-cell vaccine, Tovaxin, for multiple sclerosis
CeNeRx BioPharma Inc., of Research Triangle Park, N.C., said top-line results from a Phase I trial of Tyrima, its lead candidate for depression and anxiety, showed the drug to be safe and well tolerated
The initial top-line results showed CTA018 was safe and well tolerated