Threshold Pharmaceuticals Inc., of South San Francisco, received a $20 million milestone payment from Darmstadt, Germany-based Merck KGaA, which was triggered by results from a clinical trial of its drug TH-302 in pancreatic cancer

Synta Pharmaceuticals Corp., of Lexington, Mass., and the Multiple Myeloma Research Consortium said they started a clinical trial testing ganetespib, a second-generation Hsp90 inhibitor, as a single agent and in combination with proteasome inhibitor Velcade (bortezomib, Millennium/Takeda Pharmaceutical Co. Ltd.) in relapsed multiple myeloma

SymBio Pharmaceuticals Ltd., of Tokyo, said the clinical trial notification for its Phase I trial of rigosertib in refractory and relapsed myelodysplastic syndrome had been accepted

Consequently, recruitment restrictions which had been in place for clinical trials have been lifted

received approval from Chinese regulators to begin clinical trials of its human fibrinogen to treat congenital fibrinogen deficiency and acquired fibrinogen deficiency

Nuvilex Inc., of Silver Spring, Md., said data from an early clinical trial in pancreatic cancer indicated that its Cell-in-a-Box technology, acquired from SG Austria, of Singapore, might have an effect on downstream micro metastatic disease

Oncolytics Biotech Inc., of Calgary, Alberta, said it entered an agreement for the NCIC Clinical Trials Group at Queen's University in Kingston, Ontario, to sponsor and conduct a Phase II study of Reolysin in patients with recurrent or metastatic castration-resistant prostate cancer

Assuming its clinical trial application is granted, top-line data would be available in the third quarter, with a Phase II data in DMD patients starting in the first half of 2013

Neurelis Inc., of San Diego, said the FDA cleared the investigational new drug application for NRL-1, an intranasal diazepam formulation, to begin clinical trials in acute breakthrough seizures

Rexahn Pharmaceuticals Inc., of Rockville, Md., received approval from the Hungarian Regulatory Authority and Ethics Committee for its initial clinical trial application to begin a Phase I trial of RX-3117

If it can raise enough capital in the near term, Omni Bio Pharmaceutical Inc., of Denver, said it plans to begin two new clinical trials to test the efficacy of alpha-1 antitrypsin as a treatment for Type I diabetes and graft-vs.-host disease (GVHD

The study, funded by the European and Developing Countries Clinical Trials Partnership, is being conducted in collaboration with several groups, including the South African TB Vaccine Initiative

Achillion Pharmaceuticals Inc., of New Haven, Conn., reported new clinical trial results on its portfolio of protease inhibitors including: Phase II interim 12-week treatment results with ACH-1625 to treat genotype 1 treatment-naive hepatitis C virus (HCV), exploratory data on ACH-1625 to treat HCV genotype 3 and initial proof-of-concept data for ACH-2684...The company plans to continue adding clinical trial sites, and expects to have at least 30 sites open and enrolling by the end of first quarter

Alnylam Pharmaceuticals Inc., of Cambridge, Mass., said it filed a clinical trial application with UK regulators for a Phase I trial of ALN-TTR02, an RNAi therapeutic targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis

The double-blind, placebo-controlled, randomized clinical trial in 40 patients who had received at least one anti-TNF treatment was designed to establish the best dose and administration schedule, based on immune response to the Kinoid...multicenter, 70-patient Phase II clinical trial with Fibrocaps – a dry powder topical tissue sealant to stop bleeding after or during surgery – in spinal, peripheral vascular and general surgery resulted in a highly statistically significant reduction in mean time

Affitech A/S, of Copenhagen, Denmark, said its Russian partner, IBC Generium, submitted a clinical trial application to the Russian Health Authority to begin a Phase Il trial with Affitech's lead monoclonal antibody candidate AT001/r84

Helix BioPharma Corp., of Aurora, Ontario, filed a clinical trial application with German and UK regulators seeking approval to perform its European Phase III trial of topical interferon alpha-2b in patients with cervical intraepithelial neoplasia grade 1 or 2 lesions

Aesrx LLC, of Newton, Mass., said it started a clinical trial to test Aes-103, its anti-sickling agent, in healthy volunteers

Immunicum, of Gothenburg, Sweden, said it received approval from Swedish regulators to start the first clinical trial of its cancer vaccine in kidney cancer patients...Supernus Pharmaceuticals Inc., of Rockville, Md., initiated a Phase IIb clinical trial of its SPN-810 to treat impulsive aggression associated with attention deficit hyperactivity disorder in children ages 6 to 12