The open-label, dose-escalation trial enrolled patients with the nonmuscle-invasive form of the disease who also had undergone a complete transurethral resection
The trial will consist of two parts: a dose-escalation portion in up to 48 patients followed by further investigation of the recommended dose in up to 15 additional patients
BioSante Pharmaceuticals Inc., of Lincolnshire, Ill., said 53 percent of patients achieved at least stable disease in a Phase I dose-escalation study of its GVAX prostate cancer vaccine, in combination with Yervoy (ipilimumab, Bristol-Myers Squibb Co.), in metastatic castration-resistant prostate cancer...The study will be conducted in two parts: Part A is a dose-escalation study, while Part B will use the dose levels identified in the first part to be safe and tolerable, testing those levels in up
Curis Inc., of Lexington, Mass., said partner Debiopharm Group, of Lausanne, Switzerland, initiated a Phase Ib expansion study of Debio 0932, a heat-shock protein 90 inhibitor that recently completed a Phase Ia dose-escalation study evaluating safety and maximum-tolerated dose
Marina Biotech Inc., of Bothell, Wash., said it will begin enrolling patients in the next several weeks in the second cohort of the dose-escalation phase of the START-FAP (Safety and Tolerability of An RNAi Therapeutic in Familial Adenomatous Polyposis) trial of CEQ508
Niiki Pharma Inc., of Hoboken, N.J., said it completed the dose-escalation portion of its Phase I trial of NKP-1339, a small molecule designed to down-regulate GRP78, a tumor survival and anti-apoptosis factor...Novelos Therapeutics Inc., of Madison, Wis., said it enrolled the first patient in a Phase Ib dose-escalation trial of cancer-targeted molecular radiotherapeutics compound (131)I-CLR1404 (HOT) in cancer patients with advanced solid tumors
The single-dose, dose-escalation study is designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 and 14 who are medically stable
Data from the randomized, placebo-controlled, single-dose escalation study showed that administration of ALN-TTR01 resulted in statistically significant reductions in serum TTR protein levels in ATTR patients
Oncothyreon Inc., of Seattle, said it started the Phase II portion of its Phase I/II study testing PX-866 in combination with docetaxel, following successful completion of the Phase I dose-escalation portion
The open-label, dose-escalation study, set to start by the end of the year, will test three dose levels for safety, tolerability and aspects of biological activity
The trial will consist of a dose-escalation phase, followed by expansion cohorts in breast cancer patients as well as in patients with other cancers whose tumors are characterized by a mutation of the PIK3CA gene
The dose escalation portion of the trial, enrolling up to 48 patients, will evaluate a single injection of different HTI-501 formulations into dimpled lesions of the skin followed by a Phase II portion, enrolling up to 76 patients, where multiple lesions will be targeted with the optimal dose and formulation
The open-label safety and dose escalation Ib/II trial is being conducted primarily in patients with advanced soft tissue sarcomas who have failed standard therapies
The initial Phase I dose-escalation trial will include patients with advanced solid tumors, particularly those with NSCLC, who are either refractory to standard treatment or have no standard treatment available to them
The single-ascending dose escalation study is expected to involve 32 healthy subjects and is designed to identify a dose that can be used in Phase Ib and Phase IIa studies planned in mild to moderate allergic asthma patients
Marshall Edwards Inc., of San Diego, initiated a Phase I dose-escalation trial of its lead drug candidate, ME-143, in patients with refractory solid tumors
The open-label, dose-escalation trial enrolled patients with the nonmuscle-invasive form of the disease who also had undergone a complete transurethral resection