ImmunoCellular Therapeutics Ltd., of Los Angeles, said it will expand its Phase IIb trial of ICT-107 from 102 patients to up to 123 patients with glioblastoma multiforme who are HLA-A1/A2-positive

In another, a Phase IIb, double-blind trial of LX4211 that lasted 12 weeks in 299 patients, there were substantial, dose-dependent, statistically significant reductions in HbA1c, body weight and blood pressure

GTx Inc., of Memphis, Tenn., reported data from a Phase IIb study showing that enobosarm, a selective androgen-receptor modulator, may play a role in the management of cancer patients with muscle wasting by improving physical function

GTx Inc., of Memphis, Tenn., said its Phase IIb study of enobosarm, a selective androgen receptor modulator, demonstrated improved physical function after 16 weeks of treatment, compared to placebo, in hypogonadal (low testosterone) and eugonadal (normal testosterone) subjects...Raptor Pharmaceutical Corp., of Novato, Calif., said the first patient was dosed in its Phase IIb trial testing RP103, the firm's delayed-release microbead formulation of cysteamine bitartrate, as a potential treatment of

Idenix Pharmaceuticals Inc., of Cambridge, Mass., reported results from an ongoing Phase IIb study of IDX184, a nucleotide HCV polymerase inhibitor, in combination with pegylated interferon and ribavirin (PegIFN/RBV

Addex is seeking a partner to advance dipraglurant into a Phase IIb trial for PD-LID and other indications

The company has initiated a Phase IIb trial for BM32 in 180 allergic patients

Incyte Corp., of Wilmington, Del., and Eli Lilly and Co., of Indianapolis, presented 12-week results from a Phase IIb study of baricitinib, formerly LY3009104 (INCB28050), an orally available janus kinase (JAK) inhibitor, in patients with active rheumatoid arthritis (RA) at the European League Against Rheumatism's (EULAR) Annual European Congress of Rheumatology last week

Ltd., of Tokyo, said Phase IIb safety and efficacy data for delamanid, its investigational compound in multidrug-resistant tuberculosis (MDR-TB) were published in the New England Journal of Medicine

Alnylam is focusing on ALN-TTR02 and earlier-stage pipeline products after its RNAi candidate for respiratory syncytial virus, ALN-RSV01, missed its primary endpoint in a Phase IIb trial against progressive bronchiolitis obliterans syndrome in lung transplant patients. (See BioWorld Today, May 31, 2012

The firm said the agency's guidance is being incorporated into a Phase IIb protocol and analysis plan...Implementation of the Phase IIb program with partner Galderma SA, of Levallois-Perret, France, is progressing

The company also stopped a second Phase IIb study of ALKS 37 in the same indication...The randomized Phase IIb trial will enroll approximately 220 patients at 15 sites in the U.S

Cytokinetics Inc., of South San Francisco, said an independent data monitoring committee concluded that safety data from the first cohort in the ongoing Phase IIb ATOMIC-AHF trial supported enrollment of the second cohort

The company plans to start a Phase IIb trial later this year

Catalyst Pharmaceutical Partners Inc., of Coral Gables, Fla., said it reached its patient recruitment goal for a Phase IIb study of CPP-109 vigabatrin, with an estimated 210 cocaine-dependent subjects enrolled following final screening this week

NovaBay Pharmaceuticals Inc., of Emeryville, Calif., said it enrolled the first patients in its Phase IIb study, named BAYnovation, to test lead compound NVC-422 in adenoviral conjunctivitis

The company said the data validated its approach in an ongoing, fully enrolled Phase IIb double-blind study of CERE-120 in Parkinson's targeting both the substantia nigra and the putamen with an increased dose of CERE-120

Elevation Pharmaceuticals Inc., of San Diego, reported results from a Phase IIb study of EP-101 in patients with chronic obstructive pulmonary disease, showing that those with moderate disease treated with the inhalation solution formulation of long-acting muscarinic antagonist glycopyrrolate had a clinically meaningful and statistically significant improvement in lung function vs

Pearl Therapeutics Inc., of Redwood City, Calif., said previously undisclosed Phase IIb data showed that PT003, a fixed-dose combination with long-acting muscarinic antagonist glycopyrrolate and long-acting beta-2 agonist formoterol fumarate, was associated with a significant improvement in home peak expiratory flow rate (PEFR), a measure of lung function, when compared to placebo, individual components of PT003 and open-label active controls (p < 0.03 for all comparisons