Up to 144 patients will be enrolled, and the primary endpoint is objective response rate based on RECIST criteria

The company said that in the week 48 interim analysis, all subgroups of treatment-experienced patients who failed previous peginterferon and ribavirin treatment achieved substantially higher virologic response rates following treatment with TMC435-containing regimen at all doses and durations, compared with pegylated-interferon and ribavirin...The primary endpoint, overall response rate (defined as partial response or greater) was 24 percent with a median duration of response of 7.8 months

While a 22 percent molecular response rate was expected, 80 percent of patients achieved a complete molecular response, all within the first cycle of treatment

Rapid response rates were achieved across various clinical response measures, including good/moderate EULAR response rates at weeks six and 12 (67.4 percent and 77.6 percent, respectively, vs. 27 percent and 29.1 percent for placebo

Millennium, of Cambridge, Mass., a unit of the Takeda Oncology Co., said results of a randomized Phase III trial that investigated the effect of consolidation with single-agent Velcade (bortezomib) for Injection in newly diagnosed multiple myeloma patients after autologous stem cell transplant showed significant improvements in response rates and progression-free survival, while the overall survival rate was 87 percent in both arms after a median follow-up of 27 months

placebo in reducing signs and symptoms of RA, as measured by ACR20 response rates at six months...placebo in reducing signs and symptoms of RA, as measured by ACR20 response rates

YM BioSciences Inc., of Mississauga, Ontario, said updated interim anemia response data for the first 60 patients in its Phase I/II trial of JAK1/JAK2 inhibitor CYT387 in myelofibrosis showed an overall anemia response rate of 58 percent in 33 transfusion-dependent patients

placebo in reducing signs and symptoms of rheumatoid arthritis (RA), as measured by ACR20 response rates at six months

The single-arm screening study is expected to involve up to 30 patients and will evaluate a combination of objective response rate and early progression as the primary endpoint

CPOP produced high rates of complete remissions and overall response rate

The study met its primary endpoint of overall response rate, showing that vismodegib shrank tumors in a predefined percentage of people in the study...The trial, with an overall response rate of 19 percent, provided early clinical proof of concept for the combination of NADH oxidase inhibitors with standard-of-care chemotherapy and laid the ground work for the study of the company's next-generation compound, NV-143

In the Phase II portion, an additional 39 patients will be enrolled, and the goal is to assess the complete response rate, as well as overall subject response, time to progression, time to next treatment, duration of response and safety

The primary endpoint is to determine the safety, dose-limiting toxicity and recommended Phase II dose, while secondary endpoints will assess overall response rate, as measured by RECIST criteria, as well as progression-free survival, overall survival and exploratory biomarkers...Objectives of the study include assessing the efficacy of oral PLX3397 as measured by overall response rate, as well as the duration of response, the disease control rate, progression-free survival, response biomarkers and

placebo in reducing signs and symptoms of rheumatoid arthritis, as measured by ACR20 response rates at six months, as well as in improving physical function, as measured by mean change in HAQ DI at three months, and in reaching DAS20-4 < 2.6 months

Secondary endpoints include time to progression, overall survival, overall response rate and response duration

4SC AG, of Planegg-Martinsried, Germany, reported final data from its ENTRANCE Phase IIa study of vidofludimus, an oral inhibitor of interleukin-17 release and DHODH, in inflammatory bowel disease, which supported previously reported top-line primary endpoint data showing a total response rate of 88.5 percent

Secondary endpoints include progression-free survival, time to progression and overall response rate

The complete response rate in those patients was 86 percent...Among the 32 evaluable mantle-cell lymphoma patients, the overall response rate was 91 percent and the complete response rate was 72 percent

Photocure ASA, of Oslo, Norway, reported Phase II results showing that Cevira, a photodynamic therapy that combines a drug formulation and a medical device designed for the nonsurgical treatment of cervical human papillomavirus infection and precancerous lesions of the cervix, produced a three-month response rate of 71 percent in patients with mild cervical abnormalities vs. 43 percent in the control group