The company also stopped a second Phase IIb study of ALKS 37 in the same indication...The randomized Phase IIb trial will enroll approximately 220 patients at 15 sites in the U.S

Cytokinetics Inc., of South San Francisco, said an independent data monitoring committee concluded that safety data from the first cohort in the ongoing Phase IIb ATOMIC-AHF trial supported enrollment of the second cohort

The company plans to start a Phase IIb trial later this year

Catalyst Pharmaceutical Partners Inc., of Coral Gables, Fla., said it reached its patient recruitment goal for a Phase IIb study of CPP-109 vigabatrin, with an estimated 210 cocaine-dependent subjects enrolled following final screening this week

NovaBay Pharmaceuticals Inc., of Emeryville, Calif., said it enrolled the first patients in its Phase IIb study, named BAYnovation, to test lead compound NVC-422 in adenoviral conjunctivitis

The company said the data validated its approach in an ongoing, fully enrolled Phase IIb double-blind study of CERE-120 in Parkinson's targeting both the substantia nigra and the putamen with an increased dose of CERE-120

Elevation Pharmaceuticals Inc., of San Diego, reported results from a Phase IIb study of EP-101 in patients with chronic obstructive pulmonary disease, showing that those with moderate disease treated with the inhalation solution formulation of long-acting muscarinic antagonist glycopyrrolate had a clinically meaningful and statistically significant improvement in lung function vs

Pearl Therapeutics Inc., of Redwood City, Calif., said previously undisclosed Phase IIb data showed that PT003, a fixed-dose combination with long-acting muscarinic antagonist glycopyrrolate and long-acting beta-2 agonist formoterol fumarate, was associated with a significant improvement in home peak expiratory flow rate (PEFR), a measure of lung function, when compared to placebo, individual components of PT003 and open-label active controls (p < 0.03 for all comparisons

Cytochroma Ltd., of Markham, Ontario, reported data from a 78-subject Phase IIb trial showing that CTAP101 capsules effectively and safely lowered elevated plasma intact parathyroid hormone (iPTH) in patients with Stage III or Stage IV chronic kidney disease and vitamin D insufficiency

Auxilium Pharmaceuticals Inc., of Malvern, Pa., reported that data from its Phase IIb trial of Xiaflex (collagenase clostridium histolyticum), a first-in-class biologic for the potential nonsurgical treatment of Peyronie's disease, were published on The Journal of Urology's website...Resverlogix Corp., of Calgary, Alberta, reported that dosing in SUSTAIN, a Phase IIb trial to assess lipid trends and safety of RVX-208, has been completed on schedule

The study will be conducted in parallel with an ongoing Phase IIb trial in diabetic macular edema

Zalicus Inc., of Cambridge, Mass., said it completed enrollment with 292 patients in its Phase IIb trial, dubbed SYNERGY, designed to test Synavive, a low-dose glucocorticoid, in patients with rheumatoid arthritis

Anthera Pharmaceuticals Inc., of Hayward, Calif., said it completed dosing in its Phase IIb PEARL-SC study of monthly and weekly subcutaneous administration of blisibimod in subjects with systemic lupus erythematosus (SLE

BMS also reported that its peginterferon lambda-1a (Lambda) plus ribavirin achieved sustained virologic response 24 weeks after treatment (SVR24) in a Phase IIb (EMERGE) trial in 118 treatment-naive patients with chronic genotype 2 or 3 hepatitis C virus

CrystalGenomics Inc., of Seoul, South Korea, reported results from a Phase IIb osteoarthritis trial of CG100649, its next-generation nonsteroidal anti-inflammatory drug candidate, showing that the trial met its primary and secondary endpoints evaluating the safety, analgesic efficacy and functional benefits of CG100649 vs. Celebrex (celecoxib, Pfizer Inc.) over a four-week treatment period in subjects recording moderate to severe hip or knee osteoarthritis pain...Separately, Idenix said it

said final results from a Phase IIb (RESTORE-CLI) trial of ixmyelocel-T, a stem cell therapy for critical limb ischemia, showed improved time to treatment failure (62 percent risk reduction) compared to the control group...Based on those data, Allergan initiated a Phase IIb trial comparing two high doses of AGN-150998/MP0112 to standard-of-care Lucentis (ranibizumab, Roche AG

GTx Inc., of Memphis, Tenn., said it submitted a complete response to the FDA's letter regarding a full clinical hold on three ongoing Phase II and Phase IIb trials of Capesaris, a selective estrogen receptor alpha agonist, as primary and secondary therapy for advanced prostate cancer

Pearl Therapeutics Inc., of Redwood City, Calif., said it has manufactured metered-dose inhalers delivering 300 nanograms per actuation of glycopyrrolate (GP), a long-acting muscarinic antagonist, for its Phase IIb and Phase III trials of the product for chronic obstructive pulmonary disease

Neurocrine said the results were sufficient to move the drug, a vesicular monoamine transporter 2 inhibitor, into larger Phase IIb trials as planned