Two patients - one with breast cancer and one with lung cancer - achieved stable disease at the maximum tolerated dose level, while a patient with colorectal cancer had stable disease at a higher dose level

Like a previously reported Phase II pressure ulcer trial, the mid-dose level of RGN-137 appeared to be the most active dose, with 33 percent of patients in that group having complete healing compared to 24 percent in the placebo group, 16 percent in the low-dose group and 17 percent in the high-dose group

The trial will enroll about 120 healthy adult volunteers and is designed to test three dose levels of a single intravenous infusion of AIG compared to Gamunex (immune globulin, Talecris Biotherapeutics Inc.), a licensed therapy for people with primary immunodeficiency or idiopathic thrombocytopenic purpura

The trial involved 26 patients and tested three dose levels and two dosing regimens of the drug

The study is terminating early on the basis of overwhelming evidence of efficacy at two different dose levels of 25 mg once daily and 50 mg once daily

Medivation Inc., of San Francisco, reported data from an ongoing Phase I/II trial of MDV3100, an androgen receptor antagonist, in castration-resistant prostate cancer patients, which showed that the drug has consistently demonstrated antitumor activity across dose levels and endpoints

At dose level I, three patients achieved stable disease with no tumor progression...At dose level I, median progression-free survival was three months, and median over-all survival was five months, while at dose level II, median progression-free survival was greater than three months, and median over-all survival was greater than nine months

The primary efficacy objective was met and showed a dose-dependent effect across the three dose levels - 25 kBq/kg, 50 kBq/kg and 80 kBq/kg, respectively...The secondary endpoint of bone-specific alkaline phosphatase also showed a significant dose-dependent effect between the lowest and the two higher dose levels, as well as confirming the strong bone-targeting nature of Alpharadin, the company said

The study involves 30 patients with advanced, primary liver cancer refractory to standard therapies, with a primary objective of determining the efficacy of JX-594 at two dose levels in preventing tumor progression, as measured by modified RECIST criteria, at eight weeks from initiation of treatment

The study is a dose-escalation trial expected to enroll up to 18 patients and to test three dose levels of FG-3019 administered via infusion every two weeks

All of the dose levels were well tolerated, and no serious adverse events were observed in any study cohorts

The Phase I randomized, double-blind, placebo-controlled study for ALKS 33 will enroll 16 healthy volunteers and is designed to assess the pharmacokinetics, safety and tolerability of ALKS 33 following single oral administration at escalating dose levels

Data demonstrated that the active ingredient in Convivia significantly reduced heart palpitations, which commonly are experienced by ALDH2 deficient people who drink alcohol, at all dose levels tested

Also, SCD patients with abnormal scores of less than or equal to 1.67 at baseline demonstrated greater improvement at all dose levels (2.5, 5, 10 and 20 mg/kg

The Phase I double-blind, placebo-controlled trial is being conducted in healthy male and female volunteers to evaluate the safety, tolerability and pharmacokinetics of CCX025 over a range of dose levels...Once the maximum tolerated dose (MTD) is defined, an additional three to six patients will be enrolled at that dose level

The Phase Ib study is expected to enroll up to 26 patients and aims to evaluate the maximum tolerated dose level

The first arm of the Phase Ib/IIa study is designed to assess the safety and efficacy of various dose levels of Imprime PGG in combination with Erbitux and irinotecan, while the second arm is aimed at evaluating Imprime PGG and Erbitux alone

The upcoming Phase Ib study of ANA598 in HCV patients will explore three dose levels: 200 mg, 400 mg and 800 mg, each taken twice daily...Patients in the study are treated once daily with one of three dose levels of VIA-2291, a small-molecule drug that targets inflammation in the blood vessel wall, or placebo

The study will explore a range of six doses of APD 405 with six volunteers being enrolled at each dose level, one of whom will be randomized to receive a placebo...Paion AG, of Aachen, Germany, announced that the Phase I study with its sedative CNS 7056, a short-acting sedative/anaesthetic that acts on GABAA receptors in the brain, has progressed to the dose levels that induce pronounced sedation