Jennerex, Inc., of San Francisco, initiated the Phase IIb TRAVERSE trial evaluating the use of JX-594 to treat patients with advanced liver cancer, also known as hepatocellular carcinoma (HCC), who failed prior therapy with sorafenib (Nexavar), the only approved drug for advanced HCC...Rexahn Pharmaceuticals Inc., of Rockville, Md., reported results from a Phase IIb trial showing that Serdaxin in major depressive disorder did not demonstrate efficacy compared to placebo over an eight-week treatment
Medivir AB, of Huddinge, Sweden, reported final results from the Phase IIb ASPIRE study, showing that TMC435 once daily in addition to pegylated interferon and ribavirin produced superior rates of sustained virologic response (SVR) compared to standard of care (interferon and ribavirin alone) in patients with genotype 1 chronic hepatitis C virus (HCV) whose prior treatment with standard-of-care therapy was unsuccessful either because they relapsed, had a partial response or had a null response
Alvine said it is preparing for a Phase IIb trial of the drug, an oral mixture of recombinant gluten-specific proteases cysteine protease and prolyl endopeptidase, to start in 2012
Galderma Pharma SA, of Lausanne, Switzerland, reported top-line results from a Phase IIb trial showing that CD07805/47, a topical gel in development for moderate to severe facial erythema of rosacea, was rapidly effective at reducing facial redness...Inc., of Whitehouse Station, N.J., said results from a 24-week interim analysis of a 48-week Phase IIb study showed that 70.5 percent of patients (43/61) receiving its protease inhibitor Victrelis (boceprevir) in combination with peginterferon alfa and
Anadys Pharmaceuticals Inc., of San Diego, reported positive interim results and safety data from an ongoing Phase IIb study of setrobuvir plus the standard of care (SOC), pegylated interferon and ribavirin, in patients with genotype 1 hepatitis C. Of the subjects receiving the combination, 78 percent of treatment-naive patients and 76 percent of treatment-experienced patients had undetectable virus at Week 12, compared with 56 percent and 44 percent, respectively, for patients who received
Alvine said it is preparing for a Phase IIb trial of the drug, an oral mixture of recombinant gluten-specific proteases cysteine protease and prolyl endopeptidase, to start in 2012
The subject of a special protocol assessment agreement with the FDA, the Phase IIb trial is designed to test the drug, an alpha4beta2 neuronic nicotinic receptor therapeutic, head to head against donepezil
Cardoz AB, of Stockholm, Sweden, said it completed enrollment of 326 patients in its Phase IIb AORTA (Anti-Inflammatory ORal Treatment of AAA) trial of CRD007 in patients with abdominal aortic aneurysm (AAA...Tranzyme Pharma, of Research Triangle Park, N.C., dosed its first patient in a Phase IIb, 12-week trial of TZP-102, its oral gastrointestinal (GI) motility drug candidate
Alkermes plc, of Dublin, Ireland, said it started a Phase IIb study of ALKS 37, an oral, peripherally restricted opioid antagonist in development for opioid-induced constipation (OIC...Results from the trial, along with data from an ongoing dose-ranging, four-week Phase IIb study, are expected to be part of the firm's end-of-Phase II submission package to the FDA
Resverlogix Corp., of Calgary, Alberta, initiated dosing in its Phase IIb SUSTAIN trial of RVX-208...Resverlogix also recently started the Phase IIb ASSURE trial aimed at assessing coronary atherosclerotic plaque changes in response to RVX-208
Action Pharma A/S, of Aarhus, Denmark, released top-line results for its Phase IIb AP214 trial in patients undergoing major cardiac surgery, indicating that AP214 is safe, reduces kidney injury and improves 90-day outcomes on a composite end point (death, dialysis and kidney function) in patients undergoing cardiac surgery with cardiopulmonary bypass who are at increased risk of developing acute kidney injury...Resverlogix Corp., of Calgary, Alberta, said it opened sites for the Phase IIb ASSURE
Bionor Pharma ASA, of Oslo, Norway, reported results from a multinational Phase IIb, placebo-controlled multicenter study of Vacc-4x, a therapeutic HIV vaccine based on four synthetic slightly modified peptide sequences from conserved parts of the P24 capsid protein of the HIV virus
Pharmasset Inc., of Princeton, N.J., started a Phase IIb study of PSI-7977 and PSI-938, two nucleotide analogue polymerase inhibitors for treating chronic hepatitis C virus (HCV
TWi Biotechnology Inc., of Taipei, Taiwan, completed recruitment of 240 patients in its randomized, double-blind, placebo-controlled Phase IIb trial of AC-201 for Type II diabetes
Jennerex will proceed to a Phase IIb trial in the same indication in patients who have failed sorafenib...Pharmasset Inc., of Princeton, N.J., reported sustained virologic response (SVR) results from its Phase IIb PROTON study of PSI-7977 dosed once-daily in combination with peginterferon alfa 2a and ribavirin in treatment-naïve hepatitis C virus genotype 1 patients
Jennerex, Inc., of San Francisco, initiated the Phase IIb TRAVERSE trial evaluating the use of JX-594 to treat patients with advanced liver cancer, also known as hepatocellular carcinoma (HCC), who failed prior therapy with sorafenib (Nexavar), the only approved drug for advanced HCC...Rexahn Pharmaceuticals Inc., of Rockville, Md., reported results from a Phase IIb trial showing that Serdaxin in major depressive disorder did not demonstrate efficacy compared to placebo over an eight-week treatment