Emisphere Technologies Inc., of Cedar Knolls., N.J., said interim data from an ongoing study demonstrated its high-dose oral Eligen B12 (1,000 mcg) performed as well as or better than B12 injections in individuals with vitamin B12 deficiency

Ltd., of Cambridge, UK, completed the final Phase III trial of Flutiform (fluticasone 500 mcg/formoterol 20 mcg) in Europe, with the higher dose strength meeting its primary endpoints

Horizon Therapeutics Inc., of Northbrook, Ill., reported an analysis from two pivotal Phase III trials (REDUCE-1 and REDUCE-2) of lead compound HZT-501, a combination of ibuprofen with high-dose famotidine, showing that patients with mild to moderate pain developed about 50 percent fewer nonsteroidal anti-inflammatory-associated upper gastrointestinal ulcers compared to patients treated with ibuprofen alone

Epeius Biotechnologies Inc., of San Marino, Calif., said Phase II data showed that higher doses of Rexin-G led to improved tumor responses, as assessed by all available measures including RECIST, and nearly tripled the expected survival time, all in a dose-dependent manner, as a stand-alone therapy in chemotherapy-resistant pancreatic cancer patients...Data showed an increase in overall survival time, with more than 28 percent of patients using the high doses surviving beyond one year

Tumor growth was reduced and progression-free survival was better in those patients receiving higher doses, with seven of eight evaluable patients at the higher doses experiencing stable disease at three months vs

Results showed that the BL-1020 high-dose group (20 mg/day to 30 mg/day) produced a statistically significant reduction in PANSS vs...The EAGLE study enrolled 363 patients randomized to low or high doses of BL-1020, risperidone or placebo

Upon completion of a 12-week course of treatment, patients in all three arms (two testing doses of ITCA 650 and one testing Byetta) will be further randomized to receive higher doses of Intarcia's drug for an additional 12 weeks

The hold was imposed in late March after the FDA's review of preclinical high-dose toxicity studies resulted in some abnormal movements

Analogous investigator assessments of patients in the second cohort treated at a higher dose level achieved similar benefit at three months, and the first patient to reach a six-month assessment demonstrated further improvement

The decision to move ahead with the second cohort of the trial follows unanimous advice from the external efficacy and safety monitoring board to proceed using a higher dose of TB-402

The aim of the trial is to reduce the virologic relapse rate for those patients who have completed the standard combination therapy, which consists of high-dose injectable interferon-alpha and ribavirin

Cytos has a third trial (Study 03) ongoing, evaluating the vaccine in the same treatment regimen but at higher doses

An amended protocol for the trial will allow inclusion of younger LCA patients in the trial and the treatment of patients with higher doses of an adeno-associated virus vector containing the RPE65 gene

That decrease already was statistically significant at one week for both low- and high doses (1 mg and 10 mg

Evening administration of the highest dose of PF03187207 showed a numerical improvement over Xalatan of 12 percent in reducing diurnal intraocular pressure after 28 days, compared to baseline

Additionally, significant sustained levels of POT-4 were consistently measured via serum analysis in subjects receiving the highest dose studied, the company said

Amarillo Biosciences Inc., of Amarillo, Texas, said its partner CytoPharm Inc., of Taipei, Taiwan, will be conducting a study aimed at reducing the virologic relapse rate in patients with chronic hepatitis C virus infection who have completed the standard combination therapy of high-dose injectable interferon alpha and ribavirin

A reduction of 45 percent from baseline (corrected for placebo) was observed after 10 days at the highest dose evaluated...In addition, the protocol now includes the administration of twice-daily and higher-dose regimens of ITMN-191 in combination with R7128 in treatment-naive patients

Hybrigenics SA, of Paris, reported preliminary results from a Phase II trial of inecalcitol in hormone-refractory prostate cancer showing that the drug was well tolerated, with no changes in calcium parameters observed in any of the 42 patients enrolled to date, even at the highest dose of 1,000 mcg/day...The drug recently was placed on partial clinical hold in epilepsy due to findings of certain high-dose preclinical studies, and the firm is in the process of conduction additional preclinical