The trial, sponsored by the NCIC Clinical Trials Group, is designed to determine the compound's efficacy, which will be measured by the prostate-specific antigen responses and progression-free survival in HRPC patients who received up to one prior chemotherapy regimen

Santaris Pharma AS, of Hoersholm, Denmark, has advanced miravirsen (SPC3649), the first microRNA-targeted drug to enter clinical trials, into Phase II studies to assess the safety and tolerability of the drug in treatment-naïve patients infected with the hepatitis C virus (HCV

Two Phase III clinical trials, COMFORT-I in the U.S., Canada and Australia, and COMFORT-II in Europe, have completed enrollment and are evaluating the benefits of treatment with INCB18424 compared to either placebo or best available care...Ligocyte Pharmaceuticals Inc., of Bozeman, Mont., has initiated the first clinical trial for its bivalent intramuscular (IM) norovirus vaccine candidate, marking the fourth human clinical trial in the company's norovirus virus-like particle (VLP) vaccine program

Stem cell and gene therapy specialist Dabaghi Therapeutics Inc., of Houston, said it plans to conduct the world's first human cord blood stem cell treatment clinical trial via intramyocardial delivery

TransPharma has initiated enrollment of Type II diabetic patients in a Phase Ib clinical trial using its dry form, extended-release patch formulation of GLP1 agonist

Full results from this pilot trial are expected to be reported next year and will evaluate the possibility of a larger, randomized clinical trial using this treatment regimen...An independent safety review board reviewed all of the safety data from the clinical trial and preliminary results demonstrated that Bendavia appears to be safe and well tolerated at the doses evaluated, with no serious adverse events reported

Cempra Pharmaceuticals Inc., of Chapel Hill, N.C., initiated two clinical trials with solithromycin (CEM-101): a randomized, double-blind Phase II trial comparing an oral version of the drug to levofloxacin and a Phase I trial of an intravenous version...MAP Pharmaceuticals Inc., of Mountain View, Calif., said all four clinical trials required to support a new drug application filing for Levadex (inhaled dihydroergotamine mesylate) in acute migraine have completed enrollment

Advinus Therapeutics, of Bangalore, India, completed a Phase I single ascending dose clinical trial of its Type II diabetes therapeutic, GKM001

The first patient has been dosed in a clinical trial of monoclonal antibody therapy BAN2401 for Alzhiemer's disease by BioArctic Neuroscience AB, of Stockholm, Sweden, and Tokyo-based Eisai Co

Secondary objectives include assessing the pharmacokinetics and antitumor activity of AGS-16M8F and identifying a recommended dose and regimen for future clinical trials

Antigenics Inc., of Lexington, Mass., said that London-based GlaxoSmithKline's plc.'s herpes zoster (shingles) vaccine candidate, which contains Antigenics' QS-21 Stimulon adjuvant as a key component, has commenced Phase III clinical trials for the prevention of shingles

Celsion Corp., of Columbia, Md., said the National Cancer Institute Clinical Trials Planning Meeting for Hepatocellular Carcinoma recommended the company's 600-patient Phase III ThermoDox HEAT study as a priority trial for hepatocellular carcinoma

The clinical trial will be comprised of a single ascending dose study followed by a multiple ascending dose study to assess safety, tolerability and pharmacokinetics...Onyx Pharmaceuticals Inc., of Emeryville, Calif., has begun enrollment in the ASPIRE trial, a Phase III international clinical trial evaluating carfilzomib in combination with lenalidomide (Revlimid) and low-dose dexamethasone in patients with relapsed multiple myeloma

Dynavax Technologies Corp., of Berkeley, Calif., started the first human clinical trial in its universal flu vaccine program, a Phase I study to assess safety and immunogenicity of N8295, the novel component of Dynavax's candidate...Nymox Pharmaceutical Corp., of Hasbrouck Heights, N.J., reported results from a pooled analysis of completed clinical trials of benign prostatic hyperplasia candidate NX-1207, showing that patients receiving the drug recorded significant quantitative improvement in the

About 40 patients with advanced leukemias or other severe hematologic disorders affecting the marrow will be enrolled in the clinical trial at the MD Anderson Cancer Center

Morphotek Inc., of Exton, Pa., and Eisai Inc., of Woodcliff Lake, N.J., said regulatory authorities in the Netherlands cleared its clinical trial application for a Phase I trial of MORAb-022 in both normal volunteers and in subjects diagnosed with rheumatoid arthritis

CorMedix Inc., of Bridgewater, N.J., dosed the first patient with CRMD-001 (deferiprone) in a randomized, double-blind, placebo-controlled clinical trial

SIGA Technologies Inc., of New York, completed its fourth clinical trial testing ST-246, its lead smallpox antiviral drug candidate, with results showing that the drug likely will be found to be safe and well tolerated to treat orthopoxvirus infections

Inc., of Whitehouse Station, N.J. The 12-week, randomized clinical trial evaluated Ostarine 3 mg and two doses of MK-3984 compared with placebo in 88 postmenopausal women