Allon Therapeutics Inc., of Vancouver, British Columbia, reported top-line data from an imaging study of schizophrenia patients showing that 12 weeks of treatment with its lead neuroprotective candidate davunetide resulted in a statistically significant increase in levels of N-acetyl aspartate (NAA), a biomarker associated with brain cell health
Top-line data were reported in December 2009 by pSivida and partner Alimera Sciences Inc., of Atlanta, and a new drug application is expected in the second quarter. (See BioWorld Today, Dec. 24, 2009
Droxidopa, a synthetic precursor of norepinephrine, is in Phase III for neurogenic orthostatic hypotension associated with Parkinson's disease, with top-line data expected in the second quarter of 2011
Study 306, which evaluates Northera in patients with symptomatic NOH associated with Parkinson's disease, is scheduled to begin during the second quarter 2010 and could be completed by year-end, with top-line data in the second quarter of 2011
Biotie Therapies Corp., of Turku, Finland, reported positive top-line data from a clinical study with the VAP-1 antibody in rheumatoid arthritis, with BTT-1023 showing itself to be well tolerated and with signals of therapeutic activity
Sixty-four patients have been enrolled, and the company said its anticipates enrollment to be completed by the end of the first quarter, with top-line data available after the 90-day patient assessment review period is completed, approximately by the end of the second quarter
Almirall SA, of Barcelona, Spain, and Forest Laboratories Inc., of New York, reported positive top-line data from its three-month ACCORD Phase III trial in chronic obstructive pulmonary disease showing that aclidinium bromide produced statistically significant changes from baseline in morning pre-dose FEV1 (forced expiratory volume in one second) vs
Durect Corp., of Cupertino, Calif., said top-line data from a Phase IIb trial of Posidur did not reach statistical significance but showed a consistent reduction in pain scores and opioid use versus placebo following arthroscopic shoulder surgery
Top-line data, reported in September, fell short of showing statistical significance, though Chelsea later reported that Droxidopa-treated patients bested placebo in several secondary endpoints
Neurocrine Biosciences Inc., of San Diego, reported top-line data from its fifth Phase II trial of elagolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist for endometriosis
Those findings, presented at the Obesity Society meeting in Washington, add to the top-line data presented earlier this year, which showed a significant weight loss in patients receiving one year of treatment with lorcaserin. (See BioWorld Today, Sept. 21, 2009...Top-line data from COR-I and COR-II were reported in July. (See BioWorld Today, July 21, 2009
Allon Therapeutics Inc., of Vancouver, British Columbia, reported top-line data from an imaging study of schizophrenia patients showing that 12 weeks of treatment with its lead neuroprotective candidate davunetide resulted in a statistically significant increase in levels of N-acetyl aspartate (NAA), a biomarker associated with brain cell health