Jennerex will proceed to a Phase IIb trial in the same indication in patients who have failed sorafenib...Pharmasset Inc., of Princeton, N.J., reported sustained virologic response (SVR) results from its Phase IIb PROTON study of PSI-7977 dosed once-daily in combination with peginterferon alfa 2a and ribavirin in treatment-naïve hepatitis C virus genotype 1 patients

Kuros Biosurgery AG, of Zurich, Switzerland, said it completed recruitment in a Phase IIb trial of KUR211 in diabetic foot ulcers

Ltd., of Melbourne, Australia, said it enrolled the first subjects in a Phase IIb study of DoOvo to treat head lice

Pearl Therapeutics Inc., of Redwood City, Calif., reported data from a Phase IIb study of formoterol fumarate metered dose inhaler (FF MDI; PT005), a long-acting beta-2 agonist, compared to placebo and Foradil Aerolizer (Novartis AG) in patients with moderate to severe chronic obstructive pulmonary disease

Lasmiditan has completed five clinical trials outside the U.S., with Phase IIb results showing that it reduced moderate or severe headache at baseline to mild or none in two hours

Emergent BioSolutions Inc., of Rockville, Md., said a Phase IIb trial of tuberculosis vaccine MVA85A has been initiated in HIV patients

Glenmark Pharmaceuticals Ltd., of Mumbai, India, initiated two Phase IIb dose-ranging trials of Revamilast (GRC 4039) for asthma and rheumatoid arthritis

Action Pharma A/S, of Arhus, Denmark, said that it has completed the last visit of its last patient in a Phase IIb study of AP214 for prevention of kidney injury in patients undergoing cardiac surgery

Healthpoint Biotherapeutics, of Fort Worth, Texas, an affiliate of DFB Pharmaceuticals Inc., reported positive topline results for its Phase IIb trial investigating the efficacy of HP802-247, an investigational allogeneic living cell suspension containing keratinocytes and fibroblasts, in venous leg ulcers...The primary objective of the study is to select, based on the anti-TNFalpha immune responses, the dose levels and dosing schedule to be tested in a subsequent Phase IIb study

AB Science SA, of Paris, recruited the first patient in the Phase IIb/III study of masitinib in rheumatoid arthritis...Actelion Ltd., of Allschwil, Switzerland, reported that its selective S1P1 receptor agonist, ponesimod, met the primary endpoint – reduction in the number of new active inflammatory lesions in the brain – in a Phase IIb dose-finding study in patients with relapsing-remitting multiple sclerosis

The firm filed for an SPA last year after interim results from the Phase IIb study showed a 50 percent to 60 percent increase in amputation-free survival. (See BioWorld Today, Oct. 21, 2010

Inotek Pharmaceuticals Corp., of Lexington, Mass., completed the first two of three stages of a multiple-dose Phase IIb trial of its eye drop candidate, INO-8875, in patients with glaucoma or ocular hypertension

Pharmasset Inc., of Princeton, N.J., said that in a Phase IIb (PROTON) trial of its hepatitis C candidate, PSI-7977, 100 percent of subjects achieved a sustained virologic response, defined as HCV RNA below the limit of detection, 24 weeks after completion of the treatment...Synta Pharmaceuticals Corp., of Lexington, Mass., treated its first patient in a Phase IIb/III (GALAXY) trial of ganetespib in combination with docetaxel for non-small cell lung cancer (NSCLC

Tobira recently launched a Phase IIb study of cenicriviroc in combination with Viread and Emtriva (emtricitabine, Gilead Sciences Inc.) in treatment-naïve HIV-infected patients

Sanofi SA, of Paris, and Regeneron Pharmaceuticals Inc., of Tarrytown, N.Y., reported results from a Phase IIb (MOBILITY) trial of sarilumab in rheumatoid arthritis and ankylosing spondylitis

RVX-208 is a small molecule that facilitates endogenous ApoA-I production A Phase IIb trial is ongoing...Zalicus Inc., of Cambridge, Mass., initiated a Phase IIb trial of Synavive (dipyridamole/ low-dose prednisolone) for rheumatoid arthritis

Aastrom Biosciences Inc., of Ann Arbor, Mich., published interim data from its Phase IIb RESTORE-CLI trial of cell therapy ixmyelocel-T for critical limb ischemia in the Journal of Vascular Surgery

Adeona Pharmaceuticals Inc., of Ann Arbor, Mich., said it is planning a multicenter, double-blind, placebo-controlled Phase IIb trial to evaluate the safety and efficacy of its AEN-100, a gastroretentive, sustained-release zinc-based tablet, and AEN-200, a copper tablet, for treatment of patients suffering from amyotrophic lateral sclerosis...Anacor Pharmaceuticals Inc., of Palo Alto, Calif., said partner GlaxoSmithKline plc, of London, initiated two separate Phase IIb trials of GSK 2251052

Rexahn Pharmaceuticals Inc., of Rockville, Md., completed enrollment in its Phase IIb trial of Serdaxin, a neuroprotective and antidepressant candidate, in major depressive disorder...Tobira Therapeutics Inc., of Manalapan, N.J., started a Phase IIb trial of CCR5/CCR2 inhibitor cenicriviroc (TBR-652) in a 48-week study in 150 HIV-1-infected, antiretroviral treatment-naïve patients with only CCR5-tropic virus