Bristol-Myers Squibb Co., of Princeton, N.J., and the Gladstone Institutes, of San Francisco, formed a discovery-based research collaboration to identify and validate Alzheimer's disease targets...Poniard Pharmaceuticals Inc., of San Francisco, and Allozyne Inc., of Seattle, will terminate a merger and reorganization agreement dated June 22, following a determination that the common stock of the combined company would not qualify for listing on Nasdaq

Acumen Pharmaceuticals Inc., of South San Francisco, Calif., said partner Merck Sharp & Dohme Corp. (formerly Whitehouse Station, N.J.-based Merck & Co. Inc.) terminated the companies' agreement to develop amyloid-derived diffusible ligand targeted antibody therapeutics and diagnostics for Alzheimer's disease

AvidBiotics Inc., of South San Francisco, published new research results in PLoS Genetics regarding mutation of DNA sequences by diversity-generating elements for the purpose of directing changes in a protein molecule

Onyx Pharmaceuticals Inc., of South San Francisco, started a multiyear collaboration with the Multiple Myeloma Research Foundation in support of the MMRF's Personalized Medicine Initiative, which is designed to enable the molecular characterization of patients with multiple myeloma and advance the development of new targeted treatments

Azanta Danmark A/S, of Hellerup, Denmark, and Oxigene Inc., of South San Francisco, created an alliance to provide access to the vascular disrupting agent Zybrestat (fosbretabulin) to treat patients in Europe and Canada with anaplastic thyroid cancer (ATC) on a compassionate use basis...Genmab A/S, of Copenhagen, Denmark, said that Genentech Inc., of South San Francisco, and Biogen Idec Inc., of Cambridge, Mass., appealed the judgment in favor of GlaxoSmithKline plc, of London, in a patent

Napo Pharmaceuticals Inc., of San Francisco, said it terminated its 2005 collaboration with Glenmark Pharmaceuticals Ltd., of Mumbai, India, which licensed rights to crofelemer to Glenmark for development and commercialization in more than 140 countries for both acute and chronic watery diarrhea...Oxigene Inc., of South San Francisco, and Azanta Danmark A/S, of Hellerup, Denmark, created an alliance to provide access to the vascular disrupting agent Zybrestat (fosbretabulin) to treat patients in

VistaGen Therapeutics Inc., of South San Francisco, is collaborating with Synterys Inc., of Union City, Calif., to further VistaGen's stem cell technology-based drug rescue initiatives

Genmab A/S, of Copenhagen, Denmark, said that Genentech Inc., of South San Francisco, and Biogen Idec Inc., of Cambridge, Mass., appealed the judgment in favor of GlaxoSmithKline plc, of London, in a patent infringement case involving Arzerra, Genmab's anti-CD20 antibody, which is partnered with GSK and marketed in the U.S

Novartis has European rights to Lucentis, which is partnered with Genentech Inc., of San Francisco, a member of the Roche Group

Titan Pharmaceuticals Inc., of South San Francisco, said the final minutes of its pre-new drug application (NDA) meeting for Probuphine, a subcutaneous implant formulation of buprenorphine, confirmed the previously announced regulatory path for the program

BioSeek LLC, of South San Francisco, said it reached the first research milestone in its multiyear drug discovery collaboration with Ono Pharmaceutical Co...Genentech Inc., of San Francisco, a member of the Roche Group, said Health Canada revoked approval of Avastin (bevacizumab) as a treatment for metastatic breast cancer

Onyx Pharmaceuticals Inc., of South San Francisco, said the FDA accepted the new drug application (NDA) for carfilzomib, a next-generation proteasome inhibitor, for relapsed and refractory multiple myeloma

Galena Biopharma Inc., of Lake Oswego, Ore., entered a clinical development collaboration with Genentech Inc., of South San Francisco, and the Henry M. Jackson Foundation for the Advancement of Military Medicine to develop NeuVax (E75) in combination with Genentech's Herceptin (trastuzumab) in adjuvant breast cancer patients currently not eligible for Herceptin therapy

Genmab A/S, of Copenhagen, Denmark, said a U.S. District Court entered final judgment in favor of GlaxoSmithKline plc, of London, in a patent infringement case involving Arzerra (ofatumumab) brought against GSK by South San Francisco-based Genentech Inc. (now part of Roche AG) and Weston, Mass.-based Biogen Idec Inc

Poniard Pharmaceuticals Inc., of San Francisco, reported that its shareholders have approved proposals to complete the previously announced merger with Allozyne Inc., of Seattle

Poniard Pharmaceuticals Inc., of San Francisco, said it licensed worldwide rights to an undisclosed party to its focal adhesion kinase (FAK) technology, including a preclinical small-molecule FAK inhibitor candidate

Genmab A/S, of Copenhagen, Denmark, said a U.S. District Court entered final judgment in favor of GlaxoSmithKline plc, of London, in a patent infringement case involving Arzerra (ofatumumab) brought against GSK by South San Francisco-based Genentech Inc. (now part of Roche AG) and Weston, Mass.-based Biogen Idec Inc...VistaGen Therapeutics Inc., of South San Francisco, and the University Health Network (UHN), a Canadian research hospital, expanded their existing collaborative pluripotent stem cell

Titan Pharmaceuticals Inc., of South San Francisco, said it agreed to sell a substantial portion of its remaining future royalties on the sales of Fanapt (iloperidone), an atypical antipsychotic approved for schizophrenia in adults and marketed by Basel, Switzerland-based Novartis AG, to Deerfield Management Co

Napo Pharmaceuticals Inc., of San Francisco, terminated its 3-year-old collaboration with Salix Pharmaceuticals Inc., of Raleigh, N.C., to develop crofelemer, a diarrhea treatment