Cell Therapeutics Inc., of Seattle, received a patent for a class of small-molecule antitubulin agents with anti-proliferative and tumor-killing activity, including lead compound CT-45099

6,986,740, covering the use of Provecta, a tumor-specific small molecule, in conjunction with ultrasound imaging

It covers the potential use of Immtech's compounds as small-molecule drugs that can selectively control gene expression

NanoHorizons Inc., of State College, Pa., was awarded a patent covering the company's deposited thin-film system for high-throughput small-molecule mass spectrometry

6,531,479 covering a series of pyrimidine small molecules shown to control the progress of cells through the cancer cycle

6,828,099 titled "Protein-Fragment Complementation Assays (PCA) for the Detection of Protein-Protein, Protein-Small-Molecule and Protein-Nucleic Acid Interactions Based on the E. Coli TEM-1 Beta-Lactamase

6,727,100, which describes a method to speed up the identification of biologically active, small-molecule compounds...6,737,244 and 6,740,495, relating to its program in ubiquitin ligases and covering methods for identifying and/or measuring E3 ubiquitin ligase activity and screening for agents that modulate their activity, including small-molecule or biological modulators

6,683,192 titled "Small Organic Molecule Regulators of Cell Proliferation," covering specific small-molecule compounds that activate the Hedgehog signaling pathway

Boston Life Sciences is the exclusive licensee of the naturally occurring small molecule, which is found to control axonal growth in nerve cells

patents titled "Acyl Phosphonate Inhibitors of beta-Lactamases" and "beta-Lactamase and DD-Peptidase Inhibitors," for its small-molecule inhibitor program against bacterial beta-lactamases

6,610,505, which claims screening and developing novel small molecule therapies to modulate the JNK signaling pathway via JNK protein and cell screening that measure T-lymphocytes activity...6,613,798 titled "Mediators of Hedgehog Signaling Pathways, Compositions, and Uses Related Thereto," covering pharmaceutical compositions of small molecules under development at the company for Parkinson's disease, stroke and other neurological disorders

6,602,675, which is directed to small-molecule and enzyme discovery from both cultured and uncultured filamentous fungi and bacteria using high-throughput fluorescent screening

6,552,016 covering pharmaceutical preparations containing small-molecule compounds that selectively inhibit a biological signaling pathway controlled by the Hedgehog protein...Among the small molecules covered CUR-61414, under development to treat basal cell carcinoma

The first relates to a series of small molecules from its antithrombotics program, and the second is for the treatment of cerebrovascular disease using other internally discovered compounds

6,506,799 for its oral small-molecule program...Titled "Methods of treating cardiovascular diseases, dyslipidemia, dyslipoproteinemia, and hypertension with ether compounds," it covers methods for the use of certain small molecules to treat a variety of cardiovascular diseases

The fundamental patent describes the polynucleotide sequences encoding JNK targets that are useful to identify small-molecule JNK inhibitors that could potentially treat cancer, inflammatory diseases and ischemia reperfusion injury

A dormant form of the EPO gene is injected into muscle at the onset of treatment, followed by oral administration of Ariad's small-molecule-drug, AP22594, once or twice a month, to increase circulating levels of EPO and red blood cells directly in proportion to the amount of AP22594 administered

The small-molecule compounds described in the patent, titled "Aromatic derivatives with HIV integrase inhibitory properties," are novel anti-HIV lead molecules that target a novel mechanism of action on HIV

The small-molecule compounds described in the patent, titled "Urea derivatives as HIV aspartyl protease inhibitors," are next-generation anti-HIV lead molecules that demonstrate inhibitory activity both on laboratory strains and on multidrug-resistant strains of the virus