Calgene Inc., of Davis, Calif., was issued U.S...5,545,818, co-owned with Rutgers University, which covers expression of Bacillus thuringiensis insecticidal protein in plant chloroplasts. * Columbia Laboratories Inc., of Miami, was issued U.S...5,543,150 covering the technology used in its vaginally delivered natural progesterone gel, Crinone, to allow the sustained and targeted vaginal delivery of progesterone to the uterus. * Cytogen Inc., of Princeton, N.J., was issued U.S

The company's lead antibody, Zenapax, is being developed under a collaboration with Roche Holding Ltd., of Basel, Switzerland. * Schering-Plough Corp., of Madison, N.J., said patent No...The patent covers a system of implanting retroviral producer cells near brain tumors to infect the cancer cells with an agent that makes them susceptible to other drugs. * T Cell Sciences Inc., of Needham, Mass., received patent 5,525,461, covering the technology and products its TRAx line of diagnostics

The company uses the technology in its Gene Loader for ex vivo gene therapy. * Alexion Pharmaceuticals Inc., of New Haven, received a patent allowance covering its C5 complement inhibitor compounds, which are designed to prevent disorders caused by activation of the complement cascade and immune system. * Arris Pharmaceutical Corp., of South San Francisco, received two patents related to the company's lead compound and the drug design approach used to develop it...The company's lead antibody

The patent, which Alexion licensed from the Biotechno- logy Research and Development Corp., covers composition of porcine embryonic stem cells for producing transgenic pigs, which are used in xenotransplantation. * Cypros Pharmaceutical Corp., of Carlsbad, Calif., received a second patent for its drug, CPC-211, for protecting brain cells from damage caused by stroke and head injury...MedImmune licensed the patent from the National Heart, Lung and Blood Institute of the National Institutes of

Protogene Laboratories Inc., of Palo Alto, Calif., received patent No...The patent allows for targeted delivery of a soluble molecular complex to any receptor on any cell. * Two researchers from the University of Arizona in Tucson received patent No

The patent is co- owned by the Fred Hutchinson Cancer Research Center, in Seattle. * VivoRx Inc., of Santa Monica, Calif., received a patent covering composition and method for encapsulating biologically active materials, such as cells, in natural and synthetic polymers. * Xoma Corp., of Berkeley, Calif., received two patents related to manufacturing capability and basic research for its bactericidal/permeability-increasing protein (BPI...5,489,676, covers polypeptides that may boost BPI's

The patent covers the company's tau-peptide screening test, which detects tau-peptide fragments released in the blood by degenerating neurons. * Aradigm Corp., of Hayward, Calif., received two patents...The patent protects the manufacture, use and sale of the company's natural alpha interferon. * Isis Pharmaceuticals Inc., of Carlsbad, Calif., received patent No

Synsorb Biotech Inc., of Calgary, Alberta, was awarded U.S...5,484,773 covering the use of its technology for the treatment of gastroenteric conditions. * Xoma Corp., of Berkeley, Calif., was issued U.S

5,478,805 covers a method of fractionating and purifying PEG-hemoglobin conjugates. * Immunomedics Inc., of Morris Plains, N.J., was issued U.S...InSite licensed the patent from the University of California. * Matritech Inc., of Newton, Mass., received a notice of allowance on its patent application relating to the discovery of certain nuclear matrix proteins as highly accurate markers for colon cancer. * Metabolix Inc., of Cambridge, Mass., was awarded U.S

Aastrom Biosciences Inc., of Ann Arbor, Mich., was issued U.S...patent for Pentafuside and related compounds, which are selective HIV inhibitors. * Xoma Corp., of Berkeley, Calif., said it will be issued two U.S

Regeneron Pharmaceuticals Inc., of Tarrytown, N.Y., and its collaborator were issued two U.S...5,438,121, covering BDNF proteins and compositions. * Somatix Therapy Corp., of Alameda, Calif., was issued U.S...5,449,614 covering the use of a packaging cell line to produce non-replicating retroviral vectors for human gene therapy. * Texas Biotechnology Corp., of Houston, was issued U.S

Vertex Pharmaceuticals Inc., of Cambridge, Mass., was issued U.S...5,439,939 covering the use of VX- 366 to treat hemoglobin disorders. * Xoma Corp., of Berkeley, Calif., said it was issued U.S

Applied Immune Sciences Inc., of Santa Clara, Calif., said it was issued a U.S...patent for its technology that enables removal of selected factors from whole blood or its components. * Cypros Pharmaceutical Corp., of Carlsbad, Calif., said it was issued a notice of allowance for a composition of matter patent covering a broad class of novel adenosine metabolism inhibitors. * Genta Jago, of San Diego and Muttenz, Switzerland, was issued a patent claiming additional configurations, compositions

Sonus Pharmaceuticals Inc., of Bothell, Wash., was granted U.S. Patent 5,409,688 covering ultrasound contrast media compositions involving free gas microbubbles of any fluorine-containing hydrocarbon. * Synaptic Pharmaceutical Corp., of Paramus, N.J., was granted U.S. Patent 5,403,847 for use of compounds that block human alpha 1-c adrenergic receptor...patent related to use of permeation enhancers for drug delivery across biological membranes. * Xoma Corp., of Berkeley, Calif., was granted U.S