5,478,805 covers a method of fractionating and purifying PEG-hemoglobin conjugates. * Immunomedics Inc., of Morris Plains, N.J., was issued U.S...InSite licensed the patent from the University of California. * Matritech Inc., of Newton, Mass., received a notice of allowance on its patent application relating to the discovery of certain nuclear matrix proteins as highly accurate markers for colon cancer. * Metabolix Inc., of Cambridge, Mass., was awarded U.S

Amplicon licensed the patent from Cold Spring Harbor Laboratory, of New York. * AndCare Inc., of Research Triangle Park, N.C., was issued U.S...5,486,366 covering its lead- detection system. * AntiCancer Inc., of San Diego, received allowance of patent for its MetaMouse cancer model, which is created by implanting human tumors into immunodeficient mice. * Celgene Corp., of Warren, N.J., was issued U.S

Aastrom Biosciences Inc., of Ann Arbor, Mich., was issued U.S...patent for Pentafuside and related compounds, which are selective HIV inhibitors. * Xoma Corp., of Berkeley, Calif., said it will be issued two U.S

Regeneron Pharmaceuticals Inc., of Tarrytown, N.Y., and its collaborator were issued two U.S...5,438,121, covering BDNF proteins and compositions. * Somatix Therapy Corp., of Alameda, Calif., was issued U.S...5,449,614 covering the use of a packaging cell line to produce non-replicating retroviral vectors for human gene therapy. * Texas Biotechnology Corp., of Houston, was issued U.S

Agouron Pharmaceuticals Inc., of La Jolla, Calif., received a notice of allowance in its U.S...patent covering the manufacture of a protein used in its conjugate vaccine for the prevention of meningitis. * OraVax Inc., of Cambridge, Mass., received a notice of patent allowance covering the use of the monoclonal IgA antibody, HNK20, against respiratory syncytial virus. * Pharmos Corp., of New York, received a notice of allowance for a U.S

Immunomedics Inc., of Morris Plains, N.J., received U.S...patent 5,443,953 related to imaging and treatments with immunoconjugates, such as antibodies and antibody fragments, that have a unique carbohydrate attached as a binding site. * Mitotix Inc., of Cambridge, Mass., received U.S

patent 5,441,868, covering the manufacturing process for erythropoietin. * Biocircuits Corp., of Sunnyvale, Calif., received two U.S...patent 5,435,970, titled "device and method for analysis of constituents in biological fluids," covering technology for rapid, self-performing assays for whole blood, such as fingerstick tests. * Editek Inc., of Burlington, N.C., was issued U.S...patent 5,435,970, titled "device and method for analysis of constituents in biological fluids," covering technology for

Vertex Pharmaceuticals Inc., of Cambridge, Mass., was issued U.S...5,439,939 covering the use of VX- 366 to treat hemoglobin disorders. * Xoma Corp., of Berkeley, Calif., said it was issued U.S

Applied Immune Sciences Inc., of Santa Clara, Calif., said it was issued a U.S...patent for its technology that enables removal of selected factors from whole blood or its components. * Cypros Pharmaceutical Corp., of Carlsbad, Calif., said it was issued a notice of allowance for a composition of matter patent covering a broad class of novel adenosine metabolism inhibitors. * Genta Jago, of San Diego and Muttenz, Switzerland, was issued a patent claiming additional configurations, compositions

Sonus Pharmaceuticals Inc., of Bothell, Wash., was granted U.S. Patent 5,409,688 covering ultrasound contrast media compositions involving free gas microbubbles of any fluorine-containing hydrocarbon. * Synaptic Pharmaceutical Corp., of Paramus, N.J., was granted U.S. Patent 5,403,847 for use of compounds that block human alpha 1-c adrenergic receptor...patent related to use of permeation enhancers for drug delivery across biological membranes. * Xoma Corp., of Berkeley, Calif., was granted U.S