Spectrum Pharmaceuticals Inc., of Henderson, Nev., promoted Steven M. Fruchtman to vice president and chief medical officer and Nozar Azarnia to vice president of biostatistics and data management...Tetragenetics Inc., of Cambridge, Mass., appointed Marco Cacciuttolo president and CEO...It also named Ben Machielse and Robert Gailus to its board

Pacira Pharmaceuticals Inc., of Parsippany, N.J., appointed Laura A. Brege and Paul J. Hastings to its board...PolyTherics Ltd., of London, named John Burt CEO and board member after Keith Powell stepped down...Resolve Therapeutics LLC, of Seattle, named Peter Kiener chairman and added Somu Subramaniam as an observer to the board

It also named Patrick Hwu and Mario Sznol to its recently formed scientific and medical advisory board and named Martin Schroeder to its board

Co-founder Douglas P. Clark was named chief medical officer and acting CEO, effective July 1...Compass Biotechnologies Inc., of Edmonton, Alberta, appointed Joseph Sinkule president and chief operating officer...Cytochroma Inc., of Markham, Ontario, appointed Cynthia Lavoie and Osamu Otani to its board

Proteostasis Therapeutics Inc., of Cambridge, Mass., named Alfred Goldberg and Daniel Finley scientific co-founders...It also appointed Suzanne L. Bruhn, Vijay B. Samant and Timothy P. Walbert to its board...Yaupon Therapeutics Inc., of Radnor, Pa., appointed Steve Tullman chairman and CEO

An item in the May 19, 2011, edition of BioWorld Today's Appointments and Advancements column should have said that Adimab LLC appointed Frances Heller to its board

Neoprobe Corp., of Dublin, Ohio, appointed Mark Pykett president and CEO...Regulus Therapeutics Inc., of La Jolla, Calif., named Lars Karlsson vice president of immunology and fibrosis...Tobira Therapeutics Inc., of Manalapan, N.J., named Andrew Hindman president and CEO

Concert Pharmaceuticals Inc., of Lexington, Mass., appointed Mark Roessel vice president of regulatory affairs and quality assurance and named LuAnn Sabounjian vice president of clinical operations...Infinity Pharmaceuticals Inc., of Cambridge, Mass., appointed Joshua D. Hamermesh vice president of business and corporate development...Lightlake Therapeutics Inc., of London, appointed Cynthia McCormick as senior clinical and regulatory advisor

Access Pharmaceuticals Inc., of Dallas, named Anthony Mottola vice president of managed care and market access...Actelion Ltd., of Allschwil, Switzerland, nominated Jean-Pierre Garnier and Robert Bertolini to its board...Ampio Pharmaceuticals Inc., of Greenwood Village, Colo., appointed Mark D. McGregor chief financial officer and corporate secretary

KaloBios Pharmaceuticals Inc., of South San Francisco, added Jonathan Leff as chief medical officer and named Gary A. Lyons to its board...Labopharm Inc., of Laval, Quebec, elected Mark D'Souza president, CEO and board member...Pro-Pharmaceuticals Inc., of Newton, Mass., named Peter G. Traber president and CEO

Addex Pharmaceuticals Ltd., of Geneva, proposed adding Hoyoung Huh and Oleg Nodelman to the board...Codexis Inc., of Redwood City, Calif., named Jacques Beaudry-Losique vice president of corporate development and strategy

Pearl Therapeutics Inc., of Redwood City, Calif., appointed Chuck Bramlage president and CEO...Plethora Solutions Holdings plc, of London, appointed Richard Horsman to its board and named Billy Hargan vice president of commercial operations...Protox Therapeutics Inc., of Vancouver, British Columbia, named William Rohn and Arnit Sobti to its board

ATyr Pharma, of San Diego, formed a therapeutic advisory board comprising Thomas O. Daniel, L. Patrick Gage, Rich Heyman, Keith James, Paul Negulescu, Timothy Rink, Wendell Wierenga and Doug Williams...Otonomy Inc., of San Diego, appointed G. Michael Wall vice president of product development and named Cindy Berejikian vice president of program management

BioNanomatrix Inc., of Philadelphia, named R. Erik Holmlin president, CEO and director...It also added Michael Handelman as chief financial officer, treasurer and secretary...Medgenics Inc., of Misgav, Israel, added Isaac Blech and Raymond Dean Hautamaki to its board

Oncos Therapeutics, of Helsinki, Finland, appointed Jonathan Knowles and Robert Burns to its board...Soligenix Inc., of Princeton, N.J., appointed Kevin Horgan senior vice president and chief medical officer...Topaz Pharmaceuticals Inc., of Horsham, Pa., appointed Mark Strobeck vice president and chief business officer

executive vice president and chief operating officer and named John A. Bellano senior vice president of sales and commercial programs

The firm also named Lori M. Henderson vice president, general counsel and secretary...Anadys Pharmaceuticals Inc., of San Diego, named Kevin L. Eastwood senior vice president of corporate development, promoted James Appleman to senior vice president of research and chief scientific officer, appointed James L. Freddo to the board and named Stelios Papadopoulos chairman...AspenBio Pharma Inc., of Castle Rock, Colo., added Erik S. Miller as vice president of marketing and business development

Markus Leyck Dieken senior vice president and general manager, Germany...and Manuela Maronati vice president, sales and marketing, Europe

OctoPlus NV, of Leiden, the Netherlands, named Jan Hendrik Egberts and nominated him for appointment as CEO...Optimer Pharmaceuticals Inc., of San Diego, named Kurt Hartman general counsel and access...Protox Therapeutics Inc., of Vancouver, British Columbia, named Lars Ekman chairman and added Jonathan Leff and Nishan de Silva to the board