Nanogen Inc., of San Diego, added Ira Marks as vice president of business development and said Randy Berholtz will assume the role of acting general counsel and secretary

DoubleTwist Inc., of Oakland, Calif., appointed Simon Tomlinson vice president of worldwide sales and Gregory Thayer chief financial officer and general counsel...Progenics Pharmaceuticals Inc., of Tarrytown, N.Y., promoted Thomas Boyd to vice president, preclinical development and project management, and Philip Yachmetz to vice president and general counsel

Advanced Neuromodulation Systems Inc., of Dallas, named Kenneth Hawari general counsel and executive vice president, corporate development

Northwest Biotherapeutics Inc., of Bothell, Wash., added Jim Johnston as executive vice president, chief financial officer and chief general counsel...RxKinetix Inc., of Louisville, Colo., named John Carpenter, Mark Manning and Ted Randolph to its scientific advisory board

Cubist Pharmaceuticals Inc., of Lexington, Mass., added Michael Bonney as president and chief operating officer and Christopher Guiffre as vice president, general counsel and secretary

Pharmacopeia Inc., of Princeton, N.J., appointed Michael Lenahan executive vice president and general counsel and William DeLorbe executive vice president, human resources

Also, the company appointed Thomas Bucknum executive vice president and general counsel...Vertex Pharmaceuticals Inc., of Cambridge, Mass., named Kenneth Boger senior vice president and general counsel

Amylin Pharmaceuticals Inc., of San Diego, added Lloyd Rowland as vice president and general counsel...ArQule Inc., of Woburn, Mass., appointed Alan Hillyard chief information officer and Jean Devine director of investor relations

and promoted Sergio Garcia-Rodriguez to vice president, legal, general counsel and assistant secretary

ICN Pharmaceuticals Inc., of Costa Mesa, Calif., named David Watt executive vice president of its worldwide biomedicals group and Gregory Keever executive vice president and general counsel...It also named Mary-Helen Binger director of clinical development and project manager for MPC-7869, its prostate cancer compound

Perlegen Sciences Inc., of Santa Clara, Calif., added Vern Norviel as general counsel and corporate secretary...Structural GenomiX Inc., of San Diego, appointed Bill Rutter and Stelios Papadopoulos to its board...and added Christoph Adams as senior vice president, business development

Hyseq Inc. , of Sunnyvale, Calif., added Li-Hsien Rin-Laures as senior vice president and general counsel...and named Lorella Donato senior director of the ligand services group at its St. Laurent site

Affymetrix Inc., of Santa Clara, Calif., added Robert Ellis as executive vice president, product development and quality, and Barbara Caulfield as executive vice president and general counsel...and David Speechly vice president, European corporate and financial communications for Applera Corp

and said Viviana Amzel joined the company as general counsel, chief intellectual property officer and corporate secretary

Medarex Inc., of Princeton, N.J., promoted Bradford Middlekauff to senior vice president, general counsel and secretary...Also, it added Catherine Kara as senior intellectual property counsel and both Brian Stalter and Douglas Haeuber as assistant general counsel

Dendreon Corp., of Seattle, added Deborah Elvins as associate general counsel and Mitchell Gold as vice president of business development...Pamela Hay senior vice president, corporate development and strategic opportunities...Albert Edge vice president of discovery and preclinical research

Vical Inc., of San Diego, appointed Alan Dow vice president and general counsel and re-elected Patrick Latterell, Gary Lyons and Dale Smith as directors

Battelle Pulmonary Therapeutics Inc., of Columbus, Ohio, added Bethany Beck as vice president and general counsel...and David Westaway as senior vice president and general manager, oncology

Sequenom Inc., of San Diego, promoted Clarke Neumann to vice president and general counsel...ViroLogic Inc., of South San Francisco, appointed Kathy Hibbs vice president and general counsel