At the time, the compound was in Phase II studies as a single agent in patients with refractory indolent non-Hodgkin's lymphoma (iNHL) and in combination with rituximab (Rituxan, Roche AG and Biogen Idec Inc.) for older patients with first-line CLL. (See BioWorld Today, Feb. 23, 2011.) Leerink Swann LLC analyst Howard Liang was among the first to predict that ASCO could be a breakthrough conference for Gilead in cancer, writing after abstracts dropped that the company "may have a surprisingly

Roche AG $595M Edison Pharmaceuticals Inc...Roche AG $393M Ambrx Inc

The agreement was worth $10 million up front, $10 million in equity and up to $121 million in milestone payments for each of up to 10 targets for a total value of $1.2 billion plus research funding and royalties. (See BioWorld Today, Jan. 9, 2007.) In 2009, PTC signed a potential $1 .9 billion GEMS agreement with Roche AG, of Basel, Switzerland, receiving $12 million up front and research funding to identify small molecules that hit four jointly selected central nervous system disease targets

Separately, Roche AG, of Basel, Switzerland, said it formed an alliance with QB3 and Mission Bay Capital that includes similar structure and goals...Roche AG, of Basel, Switzerland, said Curie-Cancer, the body responsible for developing Paris-based Institut Curie's industry partnership activities, and the Roche Institute for Research and Translational Medicine are strengthening their collaborative efforts

Roy S. Herbst, professor of medicine at Yale University Cancer Center and chief of medical oncology at Smilow Cancer Hospital at Yale-New Haven, summarized a Phase I expansion study of MPDL3280A, a human monoclonal antibody currently in development at Genentech Inc., a unit of Roche AG, of Basel, Switzerland

For instance, compounders often split Roche AG's Avastin (bevacizumab) so it can be used as a cheaper, off-label alternative to the company's Lucentis (ranibizumab) in treating wet age-related macular degeneration and other eye diseases. (See BioWorld Today, March 26, 2013.) "This is a new type of practice that has evolved, and it raises the stakes on the risks," Woodcock testified Thursday

Ablynx NV, of Ghent, Belgium, initiated preclinical development of next-generation anti-IgE Nanobody ALX-0962 in severe allergic asthma. ALX-0962 consists of a potent anti-IgE Nanobody with a dual mode of action – the ability to bind with high affinity to IgE while also displacing receptor-bound IgE – together with a serum albumin binding Nanobody for in vivo plasma half-life extension. BioAlliance Pharma SA, of Paris, reported the International Independent Board of Experts' data and safety

Inc., of Whitehouse Station, N.J. (See BioWorld Today, Feb. 3, 2012.) In all, pharmaceutical companies collectively jettisoned 150,000 jobs worldwide over the past three years, according to a report earlier this year by PwC's Health Research Institute. (See BioWorld Today, Feb. 8, 2013.) Founded in 1983 as Oncogene Science Inc., OSI developed cancer drug Tarceva (erlotinib) in partnership with Genentech Inc., now a unit of Roche AG, of Basel, Switzerland

ErbB1, better known as epidermal growth factor receptor, or EGFR, is the target of drugs such as Tarceva (erlotinib, Roche AG and Astellas Pharma Inc.), Iressa (gefitinib, AstraZeneca plc.), Vectibix (panitumumab, Amgen Inc.) and Erbitux (cetuximab, Eli Lilly and Co.) Roche drugs Herceptin (trastuzumab), Perjeta (pertuzumab) and Kadcyla (trastuzumab emtansine) target ErbB2, which also goes by HER2/neu

The FDA approved Roche AG's Zelboraf (vemurafenib) for the treatment of BRAF V600E mutation-positive, inoperable or metastatic melanoma, as determined by an FDA-approved test...Kadcyla is marketed by Roche AG unit Genentech Inc., of South San Francisco

Curis earned a $4 million milestone payment from Genentech Inc., of South San Francisco (a unit of Roche AG), as a result of the Australian approval

Isis and GSK inked their five-program option deal in 2010. (See BioWorld Today, April 1, 2010.) Last month Isis partnered with Roche AG, of Basel, Switzerland, to develop antisense therapies for Huntington's disease

For instance, compounders often split Roche AG's Avastin (bevacizumab) so it can be used as a cheaper, off-label alternative to the company's Lucentis (ranibizumab) in treating wet age-related macular degeneration and other eye diseases. (See BioWorld Today, March 26, 2013.) "This is a new type of practice that has evolved, and it raises the stakes on the risks," Woodcock testified Thursday

Rimsima, a biosimilar of Remicade (infliximab, Johnson and Johnson), and a biosimilar version of Herceptin (trastuzumab, Roche AG), by Celltrion Inc

The randomized study is testing the combination of Treakisym and Rituxan (rituximab, Roche AG and Biogen Idec Inc.) vs. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone

Tolcher has been involved in running Phase I studies for a number of marketed cancer drugs, including the recently approved antibody-drug conjugate Kadcyla (trastuzumab emtansine, Roche AG), and Drejer said his appointment "brings a wealth of cancer knowledge to the company."

The product is a biosimilar version of Rituximab (Roche AG and Biogen Idec Inc.) indicated in the treatment of diseases characterized by excessive numbers of B cells, overactive B cells or dysfunctional B cells, such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia and rheumatoid arthritis

Among the top deals this year includes a partnership between Roche AG and Chiasma Inc., of New York, that could generate a total of $595 million