Having previously missed its primary endpoint of overall survival (OS) in non-small-cell lung cancer, the company said that median OS was 25.6 months compared to 22.3 months for the placebo group, with a "p" value of 0.123

Boehringer Ingelheim Pharmaceuticals Inc., of Ridgefield, Conn., part of Boehringer Ingelheim GmbH, reported data from two Phase III trials involving two investigational oncology compounds – afatinib and nintedanib – in two distinct patient populations with advanced non-small-cell lung cancer (NSCLC

The third compound due for Phase III testing in the second half of this year is selumetinib, a MEK inhibitor used in combination with docetaxel as a second-line therapy for patients with KRAS mutation-positive and metastatic non-small-cell lung cancer

The FDA approved Tarceva (erlotinib) tablets for first-line treatment of metastatic non-small-cell lung cancer characterized by tumors with epidermal growth factor receptor-activating mutations

The trial (PINNACLE) will evaluate OMP-59R5 in combination with cisplatin and etoposide in first-line, extensive-stage small-cell lung cancer

The highest response was observed in non-small-cell lung cancer and melanoma, but tumor shrinkage also was observed in kidney cancer, colorectal cancer and gastric cancer

We've also amended the Phase I trial to look at small subsets of patients with non-small-cell lung cancer, renal cancer and hepatocellular cancer," because FANG brought cause for hope in those tumors, too.

Earlier studies had shown that fusicoccin could induce apoptosis in several cancer cell lines, including colon cancer cells and lung cancer cells

The company is planning a potential pivotal trial in small-cell lung cancer and a confirmatory activity trial in endometrial cancer

The blockbuster drug was approved by the FDA in 2004 in locally advanced or metastatic non-small-cell lung cancer (NSCLC) after failure of at least one prior chemotherapy regimen

In their studies, which they published in the May 13, 2013, issue of Cancer Cell, the team sequenced the ErbB3 genes of more than 500 tumors, mainly of colorectal, gastric and non-small-cell lung cancers

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Phase IIa data showed evidence of efficacy, with five patients reported as being in remission at the final (six-month) follow-up 4/23/13 CANCER Axelar AB (Stockholm, Sweden) AXL1717 Small-molecule IGF-1 receptor inhibitor Non-small-cell lung cancer Phase II data showed it is effective 4/3/13 BioInvent International AB (Lund, Sweden) BI-505 A human antibody that binds to the ICAM-1 adhesion protein Smoldering multiple myeloma The first patient has been treated in a Phase II study 4/23/13

In the space of a few weeks that year the FDA approved Pfizer Inc.'s targeted therapy Xalkori (crizotinib) to treat certain patients with late-stage, non-small cell lung cancers (NSCLC) who express the abnormal anaplastic lymphoma kinase (ALK) gene...The company said approximately 80 percent to 90 percent of ovarian and lung cancers express the receptor, as do many other types of cancer

CytRx Corp., of Los Angeles, said an independent data safety monitoring committee (DSMC) recommended the company discontinue its Phase IIb trial with tamibarotene as first-line treatment in advanced non-small-cell lung cancer

With the multiple Phase III trials ahead, which include work by partner AstraZeneca plc, of London, with selumetinib in non-small-cell lung cancer (NSCLC), "progress in partnered programs will likely drive valuation upside from current levels," Yun wrote

was an even more high-profile failure several years earlier, in a Phase III lung cancer trial with the TLR-9 agonist PF-3512676

Merrimack Pharmaceuticals Inc., of Cambridge, Mass., reported that the last patient has been enrolled in the first cohort of a randomized Phase II trial of MM-121 in combination with erlotinib for the treatment of non-small-cell lung cancer (NSCLC

was an even more high-profile failure several years earlier, in a Phase III lung cancer trial with the TLR-9 agonist PF-3512676