Advanced Cell Technology Inc., of Marlborough, Mass., said that the vision of a patient enrolled in a clinical investigation of the company's retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs) has improved from 20/400 to 20/40 following treatment...Stem Cell Therapeutics Corp., of Toronto, said its wholly owned subsidiary Trillium Therapeutics has completed dosing in its Phase I study of TTI-1612 in patients with interstitial cystitis/bladder pain syndrome (IC

Stem Cell Therapeutics Corp., of Toronto, said the company's stock will trade on OTCQX International under the symbol "SCTPF" starting May 20

Bluebird's treatment approach involves the use of stem cells harvested from a patient's bone marrow...LentiD is designed to transduce a patient's hematopoietic stem cells with the lentiviral vector encoding ABCD1 cDNA, the gene that provides transport function in brain cells for clearing up those fatty acids

Embryonic stem cells have been the subject of so many political fights that it's easy to forget they have also faced formidable scientific obstacles...Embryonic stem cell pioneer Michael West, the co-founder of Geron Corp., of Menlo Park, Calif., and current CEO of BioTime Inc., dryly summarized the approach as "they made Starbucks clones – and it worked

Pluristem Therapeutics Inc., of Haifa, Israel, identified a first clinical indication for its Placental eXpanded (PLX) RAD cells: to enhance engraftment of hematopoietic stem cells (HSCs) in patients experiencing delays or failure of their bone marrow transplants

As with many other trials of stem cell therapies in cardiac disease, the trial is not sufficiently large to be powered for mortality only, the key measure of any cardiac therapy's efficacy...The precise mechanisms by which stem cell therapies in cardiac disease operate remain controversial

stem cells derived from human adipose tissue delivered through intravenous injection Rheumatoid arthritis Demonstrated therapeutic activity on standard outcome measures and biologic markers of inflammation for at least three months after dosing in a Phase IIa trial...it also was generally well tolerated 4/18/13 Cardio3 BioSciences SA (Mont-Saint-Guibert, Belgium) C3BS-CQR-2 A patient's own stem cells engineered to become progenitors of cardiac cells Chronic heart failure Phase II data showed it was

stem cell transplantation Hematological cancers Started a Phase I/II study to improve the outcome of hematopoietic stem cell transplantation 4/30/13 VG Life Sciences Inc. (San Marino, Calif.) Hydroxy-chloroquine Developed with metabolic disruption technology Solid tumors Phase I study was positive 4/5/13 Viralytics Ltd. (Sydney, Australia) Cavatak Administered intravenously...stem cell-derived retinal pigment epithelial cells Macular degeneration Treated patients in a third cohort of each of its

Neural stem cells are attracted to tumors for reasons that are still not fully worked out...Neural stem cells home to metastases, and brain metastases are becoming an increasing problem in cancers including breast, lung and skin cancers

stem cell product Ischemic stroke UK expanded the ongoing Phase II study to patients who have suffered an ischemic stroke 4/18/13 Gentium SpA (Villa Guardia, Italy) Defibrotide Comprises a complex mixture of the salts of single-stranded oligodeoxyribonucleotides obtained from the mucosa of pigs To prevent hepatic veno-occlusive disease Requested a re-examination of the negative opinion adopted by the CHMP regarding the MAA 4/17/13 CENTRAL NERVOUS SYSTEM Arena Pharmaceuticals Inc. (San Diego) and

Cardio3 BioSciences closed a $25 million investment round to fund an ongoing European Phase III trial of its stem cell therapy for ischemic heart failure

The study began as an attempt to identify factors in the bloodstream of young mice that could rejuvenate older animals, and co-corresponding author Amy Wagers, of Brigham & Women's Hospital, told BioWorld Today that when the studies started, she thought that any such factors would target stem cells and control regenerating tissue

As with many other trials of stem cell therapies in cardiac disease, the trial is not sufficiently large to be powered for mortality only, the key measure of any cardiac therapy's efficacy...The precise mechanisms by which stem cell therapies in cardiac disease operate remain controversial

Earlier work by Pariante and his team showed that treating cultured human embryonic brain stem cells with an antidepressant caused the cells to mature and make new brain cells...Using cultured human embryonic brain stem cells, they focused on levels of a kinase called SGK1, as it had previously been shown that expression of that molecule rises in human and rat brain cells as a result of an increase in glucocorticoid levels