Pexa-Vec, a genetically engineered pox virus that targets solid tumors, has led to tumor regression in previous Phase I trials, and a survival benefit in Phase II trials in liver cancer patients

CGTG-102 is based on the serotype 5 adenovirus, which has formed the basis of treatment for more than 15,000 cancer patients and established a solid body of safety data, explained Frans Wuite, who joined Oncos in November as president and CEO

Olaparib is slated to enter Phase III in the second half of this year as a maintenance treatment for platinum-sensitive relapsed ovarian cancer patients with BRCA gene mutations

In addition, Pexa-Vec is being evaluated in a Phase I/II trial in patients with treatment-refractory colorectal cancer as monotherapy and in combination with irinotecan, and in a Phase IIa trial in treatment-refractory kidney cancer patients

According to Kay, the only therapy option for advanced prostate cancer patients previously has been chemotherapy

Cancer Research UK licensed data from its Phase II study of rucaparib (AG014699) in breast and ovarian cancer patients with known BRCA 1 or 2 mutations to Clovis Oncology Inc., of Boulder, Colo., in return for undisclosed licensing fees

Cancer Research UK licensed data from its Phase II study of rucaparib (AG014699) in breast and ovarian cancer patients with known BRCA 1 or 2 mutations to Clovis Oncology Inc., of Boulder, Colo., in return for undisclosed licensing fees

Amgen Inc., of Thousand Oaks, Calif., said the Phase III head-to-head ASPECCT ('763) trial evaluating its Vectibix (panitumumab) vs. Erbitux (cetuximab, Eli Lilly and Co.) as a single agent for the treatment of chemorefractory metastatic colorectal cancer in patients with wild-type KRAS tumors (n = 1 ,010) met its primary endpoint of noninferiority for overall survival...The studies are evaluating the onset and incidence of OM in head and neck cancer patients undergoing chemo and radiation therapy

In separate news, Eisai said it filed a Type II variation application with the European Medicines Agency for Halaven (eribuln), requesting an indication extension to include treatment of earlier-line metastatic breast cancer patients

The immunotherapy drug, called ETBX-011, induced an immune response in advanced colorectal cancer patients and gave encouraging overall survival results

Eggs: Fresh or Stale? Researchers from the Carnegie Institution for Science have weighed in on the question of whether female mammals have germ-line stem cells that are capable of generating new egg cells. Recent reports have questioned the long-held notion that female mammals are born with all the eggs they will ever possess, suggesting instead that they have stem cells capable of generating new eggs. In their work, the researchers used a sensitive labeling system to see whether they could

The product, a small molecule that binds to S100A9, is the subject of a study across 37 countries in 1,245 metastatic castrate-resistant prostate cancer patients who have not yet received chemotherapy

The product, a small molecule that binds to S100A9, is the subject of a study across 37 countries in 1,245 metastatic castrate-resistant prostate cancer patients who have not yet received chemotherapy

I grow out my hair for a cancer patient," he said, cutting it every two years or so

cancer patients Terms were not disclosed 2/13/13 Cevec Pharmaceuticals GmbH (Cologne, Germany) Vakzine Projekt Management GmbH (Hannover, Germany) ND Exclusive license agreement relating to VPM's human cytomegalovirus dense body technology Cevec will receive worldwide development and commercialization rights from VPM, while VPM will contribute by taking over development project management services 1/4/13 Cumberland Pharmaceuticals Inc. (Nashville, Tenn.) PT

Atox Bio Ltd., of Ness Ziona, Israel, said data from an animal model of necrotizing soft-tissue infection, also known as flesh-eating bacteria, demonstrated that the administration of a single dose of AB103, given several hours after infection even without antibiotics, increased survival in animals and reduced tissue necrosis, inflammation and bacterial burden at the site of infection without compromising the immune response. AB103, a rationally designed short peptide designed to modulate the

The Phase II study is designed to evaluate whether the combination of MM-121 with paclitaxel is more effective than treatment with paclitaxel alone when administered as part of a neoadjuvant treatment regimen in two patient groups of HER2-negative, locally advanced breast cancer patients

The team looked for additional markers because the currently approved method fails to identify circulating tumor cells in a substantial fraction of breast cancer patients with brain metastases...The authors concluded that their signature "has the potential to predict which circulating cells are metastatic, but it will need to be validated in a larger number of clinical samples from breast cancer patients

The study was carried out to explore previous clinical findings with cabozantinib in castration-resistant prostate cancer patients with bone metastases showing a 67 percent rate of bone scan response and other clinical signs of effect