The double-blind, randomized, placebo-controlled study will enroll 21 participants with burn scars that restrict range of motion of jointed areas such as elbows, shoulders and fingers...The randomized, double-blind, placebo-controlled study (209AS208) evaluated the safety, tolerability and efficacy of arbaclofen in 150 ASD subjects, ages 5 to 21 years, with a particular focus on social function

Chimerix Inc., of Durham, N.C., presented the first clinical outcomes data on lead candidate CMX001 in life-threatening infection with adenovirus (AdV), a disease with no approved therapy...The randomized, double-blind, parallel group trial is evaluating TC-1734 against donepezil (Aricept, Pfizer Inc.) in approximately 300 patients at sites predominantly in Eastern Europe and the U.S. The Alzheimer's Disease Assessment Scale-cognitive subscale and the Clinician Interview-Based Impression of Change

The primary objective of the double-blind, randomized, single ascending dose study is to evaluate the safety and tolerability of rHIgM22 in subjects with MS...The primary endpoint of the randomized, double-blind, placebo-controlled trial is the effect of repeat oral dosing of the Cav2.2 selective blocker on the pain experienced in PHN after three weeks, compared with baseline

Ceregene Inc., of San Diego, reported top-line data from its double-blind, randomized, controlled Phase IIb study of CERE-120 (AAV-neurturin), a gene therapy designed to deliver the neurotrophic factor neurturin, for Parkinson's disease...The double-blind study enrolled 34 patients who received placebo or one of three different doses of LL-37

clinical trials, for SMD and dry age-related macular degeneration (dry AMD...BHR Pharma LLC, of Herndon, Va., said the 1,000th patient has been enrolled in its SyNAPSe clinical trial, a global Phase III study evaluating the effectiveness of its intravenous progesterone infusion agent, BHR-100, to treat severe traumatic brain injury (TBI...NeuroDerm Ltd., of Ness Ziona, Israel, said enrollment of patients is ongoing in its Phase IIa clinical trial of ND0612, a treatment for Parkinson's disease

The multinational, randomized, double-blind, placebo-controlled study reached the recruitment goal of 120 patients with treatment-refractory ulcerative colitis...The study is being conducted by more than 60 clinical investigators worldwide, including about 11 sites in Brazil and 24 sites in India

The randomized, double-blind, placebo-controlled trial will enroll 108 patients at about 30 sites in the U.S...Array BioPharma Inc., of Boulder, Colo., reported clinical data at the International Myeloma Workshop in Kyoto, Japan, showing that ARRY-520, a selective KSP inhibitor, demonstrated single-agent activity in heavily pretreated patients with relapsed or refractory multiple myeloma, with 19 months median overall survival and a 16 percent overall response rate

The randomized, double-blind, placebo-controlled Phase I trial is designed to assess the safety, tolerability and pharmacokinetics of single ascending oral doses of CK-2127107 in a three period, escalating dose, crossover design. (See BioWorld Today, Sept. 11, 2012...Tengion Inc., of Winston-Salem, N.C., said the firm's clinical trial application was accepted in Sweden to start a Phase I trial testing its Neo-Kidney Augment in up to five patients with advanced chronic kidney disease

The global, double-blind, placebo-controlled study enrolled 666 patients with ABSSSI at 95 sites...dosage form of either tedizolid or linezolid with the option to switch to the respective oral dosage forms at the discretion of the clinical investigator on or after the second day of treatment

The study was a 12-week, double-blind trial in which patients on stable dosages of levodopa with at least 2.5 hours of "off" time per day were randomized to tozadenant 60 mg, 120 mg, 180 mg or 240 mg BID, or matching placebo...The 21-day, inpatient, double-blind, placebo-controlled study enrolled 30 nontreatment-seeking, heroin-dependent volunteers who were maintained on oral morphine for the first 14 days

The randomized, double-blind, placebo-controlled trial will be carried out in the UK with a primary objective of safety and tolerability of single and multiple doses of subcutaneous ALN-TTRsc...The double-blind, randomized, placebo-controlled trial will assess safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple-escalating doses of the drug in healthy adults

The randomized, double-blind trial at 11 sites in North America and Europe involved 1,012 patients with acute ST-segment elevation myocardial infarction (STEMI) without a history of HF or EF < 40 percent and without signs of HF...Findings were presented during the late-breaking clinical trial session at the American College of Cardiology 62nd Annual Scientific Session in San Francisco

The ATX-101 global clinical development program has enrolled more than 2,500 total patients, of which more than 1,500 have been treated with ATX-101, the company said...The second poster titled, "Naftifine Hydrochloride Gel 2% is Efficacious and Safe for the Treatment of Tinea Pedis: Results from a Randomized, Multicenter, Double-Blind, Vehicle-Controlled Study," was designed to evaluate the efficacy and safety of two weeks once-daily application of naftifine hydrochloride gel 2 percent in the

Polyphor Ltd., of Allschwil, Switzerland, completed a Phase I trial demonstrating the clinical safety and tolerability of its Pseudomonas-specific antibiotic POL7080...All primary study objectives were achieved in the randomized, double-blind, placebo-controlled dose-escalation trial assessing the safety, tolerability and pharmacokinetics of POL7080 in 52 healthy male volunteers

The clinical trial is a randomized, double-blind, placebo-controlled parallel group study to evaluate the safety, clinical efficacy and pharmacokinetic profile of bertilimumab in subjects with active moderate-to-severe ulcerative colitis

The primary objectives include the evaluation of adverse events and the evaluation of six-month clinical response...Edison Pharmaceuticals Inc., of Mountain View, Calif., said it started a Phase II study, titled "Double-Blind, Placebo-Controlled Clinical Trial of EPI-743 in Patients with Cobalamin C Defect

Amicus Therapeutics Inc., of Cranbury, N.J., reported positive results from clinical and preclinical studies of the pharmacological chaperone AT2220 (duvoglustat HCl) in combination with ERT for Pompe disease at the Lysosomal Disease Network World Symposium...Based on those results, the company plans to initiate a repeat-dose clinical study in the third quarter of 2013 to evaluate an intravenous formulation of AT2220 co-administered with Myozyme/Lumizyme...The extension will enable the company to

Advanced Cell Technology Inc. (ACT), of Marlborough, Mass., said its clinical partner, the University of California, Los Angeles (UCLA), received FDA approval for its investigational new drug application...The single center, four-period, four-way crossover, placebo- and positive-controlled, double-blind, randomized trial will enroll 60 subjects

Celldex hopes to complete patient accrual in the randomized, double-blind, controlled study by the end of the year, with a data read-out in the second half of 2014 or early 2015 and a subsequent biologics license application filing, according to Marucci...The company will receive proceeds of $8 million, which it expects to use to fund clinical trials and for working capital and general corporate purposes.