Advanced Cell Technology Inc., of Marlborough, Mass., said that the vision of a patient enrolled in a clinical investigation of the company's retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs) has improved from 20/400 to 20/40 following treatment...Stem Cell Therapeutics Corp., of Toronto, said its wholly owned subsidiary Trillium Therapeutics has completed dosing in its Phase I study of TTI-1612 in patients with interstitial cystitis/bladder pain syndrome (IC

Bluebird's treatment approach involves the use of stem cells harvested from a patient's bone marrow...Proceeds would be used to fund clinical trials, R&D for additional alpha-1 antitrypsin (AAT) indications, expanding distribution capabilities for additional territories

Ltd., of Germantown, Md., said it filed an investigational new drug application (IND) to begin clinical trials of its adipose-derived stem cell product, RNL-JointStem, for the treatment of osteoarthritis

Chimerix Inc., of Durham, N.C., presented the first clinical outcomes data on lead candidate CMX001 in life-threatening infection with adenovirus (AdV), a disease with no approved therapy...The treatment increases the harvest of stem cells and improves the cell mixture for transplantation, with previous studies suggesting the product has a superior profile compared to existing treatment

The NIH has helped fund two clinical trials – one that's testing an insulin nasal spray to treat patients with Alzheimer's and a prevention trial in people at the highest risk of the disease. (See BioWorld Today, May 16, 2012.) Other projects include whole genome sequencing to identify new genetic variants that increase or reduce the risk of the disease, new stem cell methods, tools to improve care and steps to address inappropriate use of drugs to treat behavioral symptoms, Donald Moulds

Advanced Cell Technology Inc., of Marlborough, Mass., said the first subject in the third dosage cohort was injected with 150,000 human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells in its European Phase I trial for Stargardt's macular dystrophy (SMD...Cel-Sci Corp., of Vienna, Va., entered a co-development agreement with Ergomed, a clinical research organization (CRO), to expand its Phase III study of Multikine (leukocyte interleukin) as an injectable treatment for head

The primary objectives include the evaluation of adverse events and a six-month clinical response...Cx611 is a suspension of expanded allogeneic adult stem cells derived from human adipose tissue delivered through intravenous injection

Fifty percent (eight patients) met the primary endpoint, defined as a reduction in the Mayo score between baseline and completion of treatment, while the remaining eight patients demonstrated a stable clinical condition or minor improvement...Neuralstem Inc., of Rockville, Md., said it received approval from the FDA to start a Phase II trial using NSI-566 spinal cord-derived human neural stem cells in the treatment of amyotrophic lateral sclerosis

The patient was injected with 100,000 human embryonic stem cell-derived retinal pigment epithelial cells...clinical trials, for SMD and dry age-related macular degeneration (dry AMD

The primary endpoint of the study is the induction of clinical remission at week 12...The study is being conducted by more than 60 clinical investigators worldwide, including about 11 sites in Brazil and 24 sites in India...The TRIG-05 study is expected to begin enrollment this month, with a primary clinical endpoint of demonstrating efficacy, tolerability and safety of TI-001

Advanced Cell Technology Inc., of Santa Monica, Calif., treated patients in a third cohort of each of its two Phase I trials of human embryonic stem cell-(hESC) derived retinal pigment epithelial cells for macular degeneration...Tengion Inc., of Winston-Salem, N.C., said the firm's clinical trial application was accepted in Sweden to start a Phase I trial testing its Neo-Kidney Augment in up to five patients with advanced chronic kidney disease

Cellular Biomedicine Group, of Palo Alto, Calif., launched a clinical trial for TC-DC (Tumor Stem Cell-Specific Dendritic Cell) therapy for hepatocellular carcinoma...CALM is investigating the clinical efficacy and safety of Cavatak in Stage IIIc or IV melanoma

NurOwn is a technology for the propagation and differentiation of autologous mesenchymal stem cells (MSCs) into neurotrophic factor (NTF)-secreting cells...The Phase I/II trial showed a significantly slower decline in overall clinical and respiratory function, as measured by the ALS functional rating score (ALSFRS-R) and forced vital capacity (FVC) score, respectively, in the six patients who received an intrathecal injection of the cells in the six months following treatment, as compared to the

Cerus anticipates using the net proceeds for clinical development and other R&D activities related to the Intercept Blood System, preparatory activities for the potential commercialization of the system in the U.S...International Stem Cell Corp., of Carlsbad, Calif., raised $1 million from a number of existing longstanding investors through a private placement on the same terms as the transaction with management reported on Jan. 22

Stem Cell Therapeutics Corp., of Toronto, said it intends to file a prospectus supplement in certain Canadian provinces for its previously announced offering, consisting of up to 14 million units – each comprising one common share and one common share purchase warrant – priced at C25 cents (US24 cents) apiece...at the same unit price.

The ESS system is designed to stimulate progenitor stem cells in the bone marrow...Also, 93 percent of people in that dose group showed no clinical symptoms of influenza after three days of treatment, compared to 41 percent of people in the placebo group

In total, Ablynx has five products in clinical development and six in preclinical development, of which five are with partners...Funds will be used to advance development programs across Bionomics' pipeline, including BNC375, Bionomics' drug candidate for the treatment of Alzheimer's disease and other conditions where memory is significantly compromised and Bionomics' cancer stem cell directed drug candidate BNC101...At the completion of the capital raising, Bionomics will have approximately $26

In conjunction with the changes in its clinical program, the company said it reduced its work force by 50 percent and outsourced noncritical research and development functions...Kiadis Pharma BV, of Amsterdam, the Netherlands, said it received a No Objection Letter from Canadian regulators to proceed with a Phase II study testing ATIR, a cell-based product designed to enable stem cell transplantation from mismatched family donors

The primary objectives include the evaluation of adverse events and the evaluation of six-month clinical response...Chimerix Inc., of Research Triangle Park, N.C., presented data during the Allogeneic Transplants Poster Session at the BMT Tandem Meetings in Salt Lake City over the weekend, including data from a Phase II study testing CMX001 for the prevention of cytomegalovirus infection following allogeneic hematopoietic stem cell transplantation...Edison Pharmaceuticals Inc., of Mountain View, Calif