The company is planning to use the funds for general corporate purposes and for clinical trials of PT-100, its lead product, which is being developed in a Phase I/II trial in combination with Rituxan (Genentech Inc.) in non-Hodgkin's lymphoma and chronic lymphocytic leukemia...If the companies elect to move ahead, they would share worldwide rights.

Its lead product, PI-88, is an anti-angiogenesis cancer drug that has shown promise in clinical trials, Progen said...Ltd.

Science Editor Editor's Note: Science Scan is a roundup of recently published biotechnology-relevant research...The actual use of EZH2 as a clinical test is still several years away, though the U-M team is planning a prospective clinical trial to test its use in breast cancer patients

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...Results From Clinical Trials Of Iressa EGFR Compound Reported In Journal Oncologist The Oncologist is a bimonthly international peer-reviewed journal for physicians devoted to cancer patient care...This article highlights the results of clinical trials that demonstrate the effectiveness and safety of gefitinib

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...In its August 2003 issue, the Journal of Clinical Endocrinology & Metabolism, just released online, highlights the need to maintain a healthy diet for infants and children, once breast feeding stops

The cancer therapeutics company said in its prospectus it plans to use net proceeds to fund clinical trials and other research and development expenses...are acting as co-managers.

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...The disorder and its dramatic clinical consequences, are preventable...The editorial calls "strongly for a randomized, controlled clinical trial of vitamin D analogues in the management of this disease to determine precisely whether one vitamin D analogue is superior to another

The co-authors did clinical and experimental studies to assess the role of this newly discovered coronavirus in SARS...Their paper began: "We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARS-CoV...Laboratory investigations of clinical and postmortem samples, as already presented, fulfilled the first three criteria: (1) isolation of the virus from diseased hosts, (2) cultivation in diseased host cells, and (3) proof of filterability (to exclude

One excruciatingly painful disorder," observed clinical and research neurosurgeon Luc Jasmin, at the University of California at San Francisco, "is irritable bowel syndrome...The clinical impact of our work," he noted, "is that it opens new doors to gene therapy...The report is titled "Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

Though it has no clinical candidates, Lexicon has more than 20 targets in drug discovery programs...raised $10 million, funding the company expects to use to further develop its late-stage clinical product, Neurodex...and Peninsula Equity Partners, of Menlo Park.

An accompanying editorial commented, "The clinical utility of these indicators will depend on the ability to measure their levels in serum or plasma accurately and reliably, and on their predictive value as demonstrated in clinical studies...The co-authors concluded that "clinical studies incorporating anti-inflammatory treatment prior to percutaneous coronary intervention are awaited with great interest

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...The paper bears the title "Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial 9 (COMET): randomized controlled trial...In the COMET clinical trial, some 3,000 patients with chronic heart failure were assigned to receive twice-daily doses of carvedilol or metoprolol for about five years

The company said it would apply the funding to operations, including clinical trials, vaccine manufacturing and the repayment of about $1.2 million in equipment loans and other debt...On Friday, its stock (NASDAQ:SIGA) gained 6 cents to at $1.77.

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...In a clinical analysis of 60,770 U.S...And thirdly, we were able to demonstrate in real-life patients the beneficial effects of the recommended glycoprotein drugs compared with those enrolled in clinical trials

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...Clinical trials of other potential uses of relaxin have found only minor side effects in humans...If these results are positive," he concluded, "the fact that relaxin is so safe means we can move relatively quickly into human clinical trials

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...A clinical trial reported in the British Journal of Cancer on June 16, 2003, found that a therapeutic compound trademarked Aranesp from Amgen Inc., dosed once a month, corrects anemia and maintains hemoglobin levels in cancer patients not undergoing chemotherapy...The report appears in the June 2003 issue of the journal Clinical Genetics under the title "Association of the myocilin mt.1

In particular, it has been discussing new information on insertional oncogenesis, based on the analysis of available nonclinical and clinical data following two serious adverse events reported in a gene therapy trial in France for the treatment of children affected by X-linked severe combined immunodeficiency...It concluded that testing of gonads for the presence or expression of vector sequence "does not give sufficient information as to whether the germline has been altered."

Speeding drug approvals, by way of opening lines of communication with companies to prevent mistakes in clinical trials and the application process, appears to be at the heart of McClellan's new FDA...Well, in the first place, one of its goals is to develop biomarkers (markers of clinical benefit) for cancer drugs...For example, the NCI and FDA staffs currently are working on a clinical proteomics collaboration that could be used as a model for initiatives in areas such as diagnostic imaging and

Science Editor Editor s note: Science Scan is a roundup of recently published biotechnology-relevant research...Christiano envisages starting clinical trials for hair removal by mid-winter