Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...Results of their double-blind, placebo-controlled clinical trial are reported in the current issue of The Lancet, dated Jan. 25, 2003...The number of patients enrolled was small, so larger clinical trials should be done to confirm our findings

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...Recent advances in the use of tumor-specific immunotherapies, such as the monoclonal antibody Herceptin, have shown clinical efficacy for the treatment of metastatic mammary malignancies overexpressed by breast cancer tumors

Highlights of the initiatives that are likely to have the most impact on firms developing biotechnology medicines in Europe include updates to the existing guidance on comparability of medicines containing biotechnology-derived proteins as drug substance (as well as contributing to meetings of the EU ad hoc group dealing with clinical and preclinical issues of comparability...In terms of gene therapy and cell therapy, the plans include further advice on the quality and the preclinical and clinical

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...Novel tools for biochemically staging disease would help physicians and patients evaluate and select the most appropriate clinical approach...Ten years later, in 1754, a controlled clinical trial on another British vessel, fed 12 scurvy patients a variety of foods

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...AVI plans clinical trials against HCV in 2003

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...A controlled clinical trial invited 2,763 subjects with coronary disease to enroll in the cognitive function substudy...Clinical trials are currently in progress to determine if estrogen therapy reduces the risk of developing Alzheimer's disease and other forms of dementia

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...In a large-scale controlled clinical trial, the vaccine scored 100 percent efficacy in preventing the malignancy

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...So far, these clinical efforts have their own drawbacks, and the search continues for effective anti-angiogenic therapies...Its clinical isolates account for 34 percent of antibiotic resistance in the U.S., much higher in parts of Asia and Europe

The agency also cited the claim that "cognitive dysfunction is significantly correlated with brain atrophy," saying Biogen's clinical trials did not assess such a correlation...The voluntary moratorium follows suggestions by the FDA and USDA that pharmaceutical-product plants that out-cross should be grown only in regions of the country where little or none of the plant's food/feed counterparts is grown. (Corn is the subject of the moratorium because it out-crosses, meaning its pollen is spread by

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...The main paper describes a mechanism of tumor evasion that may also apply to the impairment of other immune defense systems, and which may well have clinical potential

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...More than 300 patent applications have been made so far for FTase inhibitors, and six or more are currently in clinical trials

Serono SA, of Rockland, Mass., reported 24-week results from a completed clinical trial of Serostim...Phase I clinical trials with repeat dosing will now be finalized and evaluated...PDF inhibitors target an enzyme that is essential to bacteria but not required in human cells.

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...He added, "This study establishes unequivocally that the normalcy of surviving cloned animals should not be based on superficial clinical examinations, but rather on detailed molecular analysis of tissues from adult cloned animals...The controlled clinical trial enrolled 2,074 women with ovarian cancer from 130 centers in eight countries

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...That means a blood sample is drawn and sent to a clinical laboratory

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...The paper concludes: "Given that there is currently no therapy for end-stage heart failure aside from heart transplantation, future studies are warranted to translate these findings into larger animal models and the clinical setting

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...In contrast to acquired clinical immunity," the Nature paper points out, "anti-parasite immunity takes many years to develop and is easily lost, reflecting the problems of antigenic diversity...They point out that their in vivo experiment differs significantly from current clinical practice, suggesting that there is no immediate cause for concern

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...They showed no clinical disease 330 days after inoculation plus repeated therapy, compared with 180 days without treatment

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...They make the point that the clinical presentation and outcome of anthrax in humans depend on the spore's route of entry into the body

Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...Efforts to develop maytansine into a clinically useful anticancer drug proved disappointing in Phase II clinical trials in the 1980s, probably because of dose-limiting toxicity in humans