Ltd., of Tokyo, said it is initiating preclinical studies required to begin clinical testing of a fully human monoclonal antibody to the influenza A M2 protein for protection against and treatment of influenza infection...The company plans to start additional clinical studies in 2006...Tibotec Pharmaceuticals Ltd., of Cork, Ireland, said primary 24-week data from the Phase 2b trial of the protease inhibitor TMC114 in treatment-experienced patients showed that 62 percent of patients achieved a

And the company intends to conduct some higher-dose, shorter-course clinical trials in adults...Proceeds will be used to conduct clinical testing of the company's GP88 Biopsy Staining Kit for breast cancer

It is thought that the ruling will not reverse the ban of high-dose ephedra...Azar served for four years as the general counsel at HHS.

A third Phase I, scheduled to begin shortly, will test higher doses in a multiple-dose fashion...Its natural properties allow for large-scale manufacturing for clinical trials, and its initial safety and toxicity profiles have proved promising...and several private investors.

But the study showed that such high doses might cause adverse side effects that induce some patients to stop taking the Arava tablets...That sex bias is particularly prevalent in clinical trials testing treatments for rheumatological diseases such as RA

Its clinical isolates account for 34 percent of antibiotic resistance in the U.S., much higher in parts of Asia and Europe...Recipients of high-dose radiotherapy had greater memory deficits than patients not exposed to radiotherapy

By David N. Leff Science Editor Editor's note: Science Scan is a roundup of recently published, biotechnology-relevant research...We let our tumors grow for a week, so they're actually established before we start the cell therapy, which is more like what would happen in a clinical setting...Intractable itchiness," neurobiologist Arthur Craig told BioWorld Today, "is a serious clinical problem for several diseases of internal organs, such as the liver and the kidney

David N. Leff Science Editor Editor's note: Science Scan is a roundup of recently published, biotechnology-relevant research...The paper concluded, "The resulting information opens the opportunity for future preclinical and clinical studies of HBsAg as an oral vaccine, with more detailed focus on communication between humoral and mucosal branches of the immune system, which may be important for the commercial development of plant-based vaccines." "A human trial of our vaccine has recently ended

By David N. Leff Science Editor Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research...They develop a form of the disease with an earlier onset and shorter duration, with unusual clinical symptoms...Reasoning that nerve growth factor (NGF) is presumed to have a hand in age-related neurodegenerative disease, they raised a strain of transgenic mice expressing a high-dose, anti-NGF recombinant antibody