Novavax Inc., of Rockville, Md., said top-line data from its Phase II dose-ranging study testing its respiratory syncytial virus (RSV) vaccine candidate in women of childbearing age hit its protocol-specified objectives, supporting progression to the next stage of advanced clinical testing

Eyeing Better Mousetrap with Topical Product In 2009, Revance granted worldwide aesthetic and dermatological rights to RT002, then in preclinical studies, to Medicis Pharmaceutical Corp., of Scottsdale, Ariz., in exchange for $10 million at signing and another potential $94 million, based on clinical, regulatory and commercial milestones...The latest round is expected to support ongoing clinical development of lead candidate, LiRIS (lidocaine releasing intravesical system), in development for

Tengion Inc., of Winston-Salem, N.C., said the firm's clinical trial application was accepted in Sweden to start a Phase I trial testing its Neo-Kidney Augment in up to five patients with advanced chronic kidney disease

Net proceeds totaled $12 million and will be used to fund R&D and clinical trials, acquisition of intellectual property and other purposes...The funds will be used to advance Theraclone's clinical programs and support its I-STAR technology platform.

dosage form of either tedizolid or linezolid with the option to switch to the respective oral dosage forms at the discretion of the clinical investigator on or after the second day of treatment

During that period, MedBridge also will provide full administrative support for the company, allowing it to focus on clinical development of the therapeutic pipeline

Benitec Biopharma Ltd., of Sydney, Australia, selected the Duke Clinical Research Unit in Durham, N.C., as a site for its upcoming Phase I/II first-in-human trial of TT-034 in hepatitis C virus (HCV...NeuroVive Pharmaceutical AB, of Lund, Sweden, said the 600th patient was recruited in its pivotal Phase III European, multicenter CIRCUS (does Cyclosporine ImpRove Clinical oUtcome in ST elevation myocardial infarction patients) trial assessing CicloMulsion in heart reperfusion injury following

It is the first immune cell clinical trial of its kind in China...A follow-on Phase II trial will include clinical markers of muscle health, levels of utrophin expression and other biomarkers...CALM is investigating the clinical efficacy and safety of Cavatak in Stage IIIc or IV melanoma

New data from the analysis showed highly significant improvements in all secondary efficacy measures, including the Clinical Global Impression Severity scale (p < 0.001), the Clinical Global Impression Improvement scale (p = 0.001) and a CGI-I responder analyses (p = 0.002...BrainStorm Cell Therapeutics Inc., of New York, reported some of the final results from a clinical study evaluating its NurOwn technology in 12 amyotrophic lateral sclerosis (ALS) patients...The Phase I/II trial showed a

Another $406 million could come in the form of clinical, regulatory and commercial milestones, and Enanta would be eligible for tiered, double-digit royalties and a U.S...Net proceeds are expected to support clinical trial costs and acquisition of manufacturing equipment, leasehold improvements and general corporate purposes...Trimel's pipeline includes CompleoTRT, a bioadhesive intranasal testosterone gel for male hypogonadism.

The company also is preparing a clinical program for marketing in Europe and the U.S

The German Federal State of Saxony and the European Union funded the grant, which supplements a grant awarded by the SAB in August 2011 for the CANVAS clinical trial...Net proceeds of about $12 million will be used to support R&D, acquisition of intellectual property related to complementary drug therapies, clinical trials and other expenses...The first tranche of the Series B closed in June 2012 for $8.6 million.

The NX03-0040 prostate cancer clinical study of 150 men is testing low (2.5 mg) and high (15 mg) single doses of NX-1207 for the effect to eradicate or shrink low-grade localized prostate cancer tumors

Secondary objectives of the trial include clinical activity by serum TTR levels...The study showed that Uceris 9 mg gave a statistically significant benefit over placebo for the primary endpoint of clinical and endoscopic remission at week eight...For the Uceris 9-mg group, 17.4 percent of patients achieved clinical and endoscopic remission, compared to 4.5 percent of the placebo group (p = 0.0047

The company also said it is initiating a new financing round – about $6 million in new convertible debt – to fund further clinical development

Cerus anticipates using the net proceeds for clinical development and other R&D activities related to the Intercept Blood System, preparatory activities for the potential commercialization of the system in the U.S...The funds, along with those received in January, will help advance the company's therapeutic programs toward clinical stage, building upon recently announced preclinical data for both the Parkinson's and liver disease programs

Cytos Biotechnology Ltd., of Zurich, Switzerland, said results from a Phase IIa trial showed that CYT003, an immune modulator for the potential treatment of asthma, met all clinical endpoints, with patients treated with CYT003 having their asthma control improved despite the withdrawal of inhaled corticosteroids (ICS...The study also will assess secondary measures of clinical benefit, including progression-free survival, objective response rate and overall survival at six months and 12 months

Proceeds will be used to fund clinical trials of IMO-8400, an agonist of Toll-like receptors 7, 8 and 9, which is in development for autoimmune and inflammatory diseases, as well as for working capital and other general corporate purposes

The study design calls for the collection of 5,250 clinical endpoints, and Merck remains blinded to the actual results of the analysis and to other safety and efficacy data