BHR Pharma LLC, of Phoenix, said it reached its SyNAPSe clinical trial enrollment midpoint of 590 patients...The original Phase IIb trial was designed to determine the potential effectiveness of two cell concentrations and two dosing frequencies of HP802-247, when combined with standard care, compared to control plus standard care, in healing venous leg ulcers over a 12-week treatment period

BioCryst Pharmaceuticals Inc., of Research Triangle Park, N.C., reported favorable 52-week safety results and sustained efficacy from the extension phase of its randomized Phase IIb trial of ulodesine (BCX4208) added to allopurinol in patients with gout who had failed to reach the serum uric acid therapeutic goal of < 6 mg/dL on allopurinol alone, as well as positive Phase II safety results in mild to moderate renal impairment...Eisai Europe Ltd., of Hatfield, UK, part of Eisai Inc., presented the

Proceeds will support clinical trials of Nexagon, CoDa's lead candidate based on gap junction modulation for treating chronic wounds, including venous leg ulcers and diabetic foot ulcers...CoDa currently is conducting a 300-patient Phase IIb study in patients with venous leg ulcers and a 160-patient diabetic foot ulcer trial. (See BioWorld Insight, March 12, 2012

After getting hammered a month ago on news of a missed primary endpoint in the Phase IIb PEARL-SC study of lupus drug blisibimod, shares of Anthera Pharmaceuticals Inc...Upon pricing, it would trade on Nasdaq under the ticker "STML." (See BioWorld Today, April 4, 2012.)

The company said it had recently completed a Phase IIb trial for the treatment of abSSSIs...and Leerink Swann LLC are acting as joint book-running managers for the offering.

EnVivo Pharmaceuticals Inc., of Watertown, Mass., reported results from its Phase IIb trial of EVP-6124, an alpha-7 agonist for Alzheimer's disease, which met both of the primary endpoints at the 2-mg dose, with statistically significant positive effects on cognition (p = 0.0189), as measured by the Alzheimer's Disease Assessment Scale-Cognitive subscale-13, and clinical function (p = 0.0253), as measured by the Clinical Dementia Rating Scale Sum of Boxes

Anthera Pharmaceuticals Inc., of Hayward, Calif., reported the final set of data from its Phase IIb PEARL-SC study of blisibimod in systemic lupus erythematosus (SLE), which suggested sustained and greater treatment effects vs...Anthera reported top-line data from the PEARL-SC study late last month, showing that the trial missed its primary endpoint, defined as clinical improvement at 24 weeks in the SLE responder index for the pooled blisibimod dose groups

Catalyst Pharmaceutical Partners Inc., of Coral Gables, Fla., said it plans to report top-line findings from the Phase IIb trial of CPP-109 (vigabatrin) in cocaine addiction at the end of the third quarter, four months earlier than planned...The trials will evaluate the difference in clinical response rates at the end of therapy, as well as sustained clinical response after treatment

Biotie Therapies Oyj, of Turku, Finland, said it completed enrollment in its Phase IIb trial testing tozadenant in Parkinson's disease and expects top-line data to be available around the end of the year...Clinical and patient-reported outcomes also will be evaluated, though the trial is not powered for those endpoints

GlobeImmune is running five clinical trials, including a Phase IIb trial of GI-4000 with gemcitabine for pancreatic cancer...Its Phase IIb study in pancreatic cancer, GI-4000-02, is a double-blind, active-control, multicenter trial of 176 subjects with resected cancer of the pancreas

ImmunoCellular Therapeutics Ltd., of Los Angeles, said it will expand its Phase IIb trial of ICT-107 from 102 patients to up to 123 patients with glioblastoma multiforme who are HLA-A1/A2-positive...Protalix BioTherapeutics Inc., of Carmiel, Israel, reported clinical data for taliglucerase alfa showing that at 36 months, patients with Gaucher disease had significant improvement in bone marrow fat fraction from baseline, with a mean change of 92 percent

Lexicon Pharmaceuticals Inc., of The Woodlands, Texas, published results from two trials of LX4211 in patients with Type II diabetes in the online edition of Clinical Pharmacology and Therapeutics...In another, a Phase IIb, double-blind trial of LX4211 that lasted 12 weeks in 299 patients, there were substantial, dose-dependent, statistically significant reductions in HbA1c, body weight and blood pressure

In addition to clearance to proceed with clinical trials, the company also received approval of the protocol from the institutional review board and scientific review committee...GTx Inc., of Memphis, Tenn., reported data from a Phase IIb study showing that enobosarm, a selective androgen-receptor modulator, may play a role in the management of cancer patients with muscle wasting by improving physical function

GTx Inc., of Memphis, Tenn., said its Phase IIb study of enobosarm, a selective androgen receptor modulator, demonstrated improved physical function after 16 weeks of treatment, compared to placebo, in hypogonadal (low testosterone) and eugonadal (normal testosterone) subjects...Several prior clinical studies demonstrated that Bendavia appeared to be safe and well tolerated with no serious adverse events across a broad dose range with highly predictable pharmacokinetics. (See BioWorld Today, April

Bristol-Myers Squibb Co., of New York, formed a strategic partnership with Emory University in Atlanta to conduct clinical trials involving the pharma's investigational compounds...Idenix Pharmaceuticals Inc., of Cambridge, Mass., reported results from an ongoing Phase IIb study of IDX184, a nucleotide HCV polymerase inhibitor, in combination with pegylated interferon and ribavirin (PegIFN/RBV

Addex is seeking a partner to advance dipraglurant into a Phase IIb trial for PD-LID and other indications...Spectrum Pharmaceuticals Inc., of Henderson, Nev., reported updated clinical data for Zevalin (ibritumomab tiuxetan) injection for intravenous use in an oral presentation at the 17th Congress of the European Hematology Association

The company has initiated a Phase IIb trial for BM32 in 180 allergic patients...PharmAthene Inc., of Annapolis, Md., said it completed final analytical testing and release of its recombinant protective antigen anthrax vaccine, SparVax, in pre-filled syringes for further clinical evaluation

In the clinical analysis, more than 1,700 patients were stratified in quartiles by baseline body weight, and results showed that A1C reduction and weight loss were comparable across all quartiles...Those data came from a Phase IIb open-label extension study...LLC, of Kalamazoo, Mich., reported Phase IIb results showing that MSDC-0160, a once-daily oral insulin sensitizer, met the primary endpoint of significantly reducing fasting plasma glucose in patients with Type II diabetes

ChemoCentryx Inc., of Mountain View, Calif., reported Phase II data showing that CCX354, a selective, oral inhibitor of chemokine receptor CCR1, was generally well tolerated by patients with rheumatoid arthritis and showed evidence of clinical activity using the ACR20 response criteria at week 12...Incyte Corp., of Wilmington, Del., and Eli Lilly and Co., of Indianapolis, presented 12-week results from a Phase IIb study of baricitinib, formerly LY3009104 (INCB28050), an orally available janus