Patients who responded to the drug in clinical trials continued to respond through five years of follow-up...Merz Pharmaceuticals GmbH, of Frankfurt, Germany, reported clinical data showing that cervical dystonia or blepharospasm patients treated with Xeomin (botulism toxin Type A) experienced long-term sustained efficacy with a favorable safety profile of up to 121 and 88 weeks duration...Xencor will lead all clinical development until that time. (See BioWorld Today, Jan. 10, 2011

Allozyne Inc., of Seattle, said a double-blind, placebo-controlled Phase Ib trial of AZ01 showed the drug was well tolerated and has a half-life two to three times longer than other pegylated interferon beta therapeutics in clinical development

Results showed that RTS,S provided young African children with significant protection against clinical and severe malaria, reducing the risk by 56 percent and 47 percent, respectively, for the 12-month period following vaccination...Ampio Pharmaceuticals Inc., of Greenwood Village, Colo., reported results from a randomized, placebo-controlled, double-blind proof-of-concept study that showed intranasal Optina (danazol) has an impact on allergic rhinitis...The primary endpoint is to evaluate the changes

The three-arm, randomized, double-blind, Australian trial enrolled 60 patients with moderate to severe osteoarthritis of the knee and tested Ampion, a low molecular fraction of commercial albumin, in two combinations: with a steroid and lidocaine, and with a steroid and saline...BAX 111 is the first recombinant von Willebrand product in clinical development

The randomized, stratified, double-blind, placebo-controlled, four-parallel group trial is being conducted at 15 sites in Denmark, Sweden and the United Kingdom, where enrolled patients will be studied for 12 months...The double-blind trial is being conducted in patients suffering from diabetic gastroparesis, a chronic GI condition affecting both Type I and II diabetics

Three randomized, double-blind, placebo-controlled Phase II studies of ATX 101 to reduce submental fat and four Phase I studies studying pharmacokinetic, histology, lipid and tolerability effects demonstrated that ATX 101 is well tolerated and may effectively reduce localized fat under the chin...Two randomized, double-blind, placebo-controlled European Phase III studies of ATX 101, enrolling more than 700 patients, already are under way in collaboration with Bayer HealthCare's dermatology unit

The randomized, double-blind, placebo-controlled study has already begun enrolling in Europe...The randomized, double-blind, placebo-controlled trial will be conducted at approximately 45 study sites in North America...The randomized, double-blind, multicenter HVTN-080 Phase I study enrolled 48 healthy, HIV-negative volunteers to assess safety and immune responses generated by Pennvax-B, which consists of SynCon immunogens targeting HIV gag, pol and env proteins from HIV subtype B. Antigen-specific T

The study, initiated in April, enrolled 52 patients at clinical sites in the U.S., Canada, Jamaica, Egypt and Lebanon to evaluate the safety and tolerability of HQK-1001...The randomized, double-blind, placebo-controlled, parallel group, multicenter study enrolled 482 people with Type II diabetes, randomized and exposed to a once-daily regimen of lixisenatide one-step dose increase (10 mcg for two weeks, then 20 mcg), lixisenatide two-step dose increase (10 mcg for one week, 15 mcg for one week

In patients who achieved clinical success but had recurrence, the mean degree of contracture had yet to return to pre-treatment levels after three years...Metabolic Solutions Development Co., of Kalamazoo, Mich., said insulin sensitizer MSDC-0160 lowered HbA1c levels in a 28-day, randomized, double-blind, comparator- and placebo-controlled Phase IIa trial for Type II diabetes

RegeneRx Biopharmaceuticals Inc., of Rockville, Md., completed enrollment of a targeted 72 patients in its double-blind, placebo-controlled Phase II trial of RGN-259 for dry eye syndrome...Senesco Technologies Inc., of Bridgewater, N.J., finalized a clinical trial agreement with the Mayo Clinic in Rochester, Minn., to study SNS01-T in relapsed or refractory multiple myeloma patients

The double-blind, placebo-controlled, NIH-funded, 297-patient study showed once-daily treatment for three days with 10-mg DAS181 resulted in a significant reduction of viral load when compared to placebo over the first 24 hours (p < 0.002), first 48 hours (p < 0.009) and from day one to day five (p < 0.008...Data published in Clinical Infectious Diseases showed that patients taking Dificid while on concomitant antibiotics demonstrated a 90 percent clinical rate vs. 79.4 percent in the vancomycin

No patients on placebo experienced a clinical response, adequate symptom relief or a biochemical response during the randomized, double-blind U.S

The Phase II, double-blind, placebo-controlled, randomized trial is expected to compare the safety and effectiveness of conventional therapy treatment plus ecallantide to conventional therapy treatment plus placebo in 176 patients enrolled at 40 U.S...The two-stage, randomized, double-blind, placebo-controlled study was conducted in Mexico during the 2009 pandemic to evaluate the safety and immunogenicity of one or two doses of the VLP vaccine in 4,563 healthy adults, 18-64

Ipsen SA, of Paris, said its partner Inspiration Biopharmaceuticals Inc., of Laguna Niguel, Calif., presented results from its clinical development program for OBI-1, an intravenous recombinant porcine factor VIII product...The randomized, double-blind, placebo-controlled, global study will enroll more than 600 patients who have failed prior systemic therapy

Daval International Ltd., of London, completed a randomized, placebo-controlled, double-blind Phase II trial of Aimspro to treat patients with bladder dysfunction with secondary progressive multiple sclerosis...The FDA granted authorization to Hemispherx Biopharma Inc., of Philadelphia, to proceed with a clinical trial of intranasal Ampligen (rintatolimod) in conjunction with flu vaccine

InVasc Therapeutics Inc., of Atlanta, initiated a randomized, double-blind, active-controlled Phase IIa trial comparing INV-144 (losartan plus alpha Lipoic Acid) to losartan alone in hypertensive diabetic patients with chronic kidney disease...Complete clinical regression of target tumors was seen in 14 of 16 patients completing the first assessment and eight of 11 patients completing the second assessment

Still, the need for chronic treatment of a population with many comorbidities has given clinical scientists plenty to keep busy with...Zafgen Inc., of Cambridge, Mass., reported results from a Phase Ib randomized, double-blind, placebo-controlled trial of its methionine aminopeptidase 2 inhibitor ZGN-433, which seeks to alter fat metabolism

4SC AG, Planegg-Martinsried, Germany, reported that new data from the oral resminostat Phase II SHELTER trial in hepatocellular carcinoma confirmed previously reported trends with regard to clinical activity...Adeona Pharmaceuticals Inc., of Ann Arbor, Mich., said it is planning a multicenter, double-blind, placebo-controlled Phase IIb trial to evaluate the safety and efficacy of its AEN-100, a gastroretentive, sustained-release zinc-based tablet, and AEN-200, a copper tablet, for treatment of

The placebo-controlled, double-blind Ostarine trials will begin next month, with the last patient visit occurring late next year...We expect to incur significant net losses in 2011 and for the foreseeable future as we continue our clinical development and research and development activities," the company said