In clinical trials, Infasurf was compared to Exosurf Neonatal, which is no longer marketed, and Survanta, over which Infasurf did not demonstrate clinical superiority

Isconova AB, of Uppsala, Sweden, carried out a fully subscribed rights issue of about SEK50 million (US$7.4 million) to finance clinical trials in-house, increase production capacity and continue research in new indications for the adjuvant Matrix M. Shareholders representing 46.3 percent committed to subscribe for their respective pro rata share of the issue, with the remainder guaranteed by a consortium

We were losing a lot of patients to these clinical trials...I'm not satisfied with this performance and not looking at clinical trials as an excuse," Johnson said...Shares of Vertex (NASDAQ:VRTX) fell $5.47 to close at $45.01.

They also identified differences in the toxic capabilities of three drugs in this class that are currently being investigated in clinical trials...The study, by scientists at the National Cancer Institute, and colleagues, appeared in Cancer Research.

The future growth of United's PAH franchise hit a snag late last month when its oral treprostinil candidate earned a complete response letter, with the FDA citing issues in the product's clinical data package

The funds will give the company enough runway to advance investigational lupus drug RSLV-132 into clinical trials, expected to begin in mid-2013

Integra focuses on biotech firms with products mostly in clinical development

EnVivo Pharmaceuticals Inc., of Watertown, Mass., said data from its Phase IIb study of EVP-6124, an alpha-7 agonist, in Alzheimer's disease met both of the trial's primary endpoints, with statistically significant positive effects on cognition (p = 0.0189), as measured by ADAS-COG-13, and clinical function (p = 0.0253), as measured by the Clinical Dementia Rating Scale Sum of Boxes...Data also showed statistically significant results across several secondary endpoints of other cognitive and

Muscle strength, clinical function and patient-reported outcomes also will be evaluated, though the study is not powered for those endpoints...two dose levels of active drug at four clinical sites in the U.S

Cellceutix Corp., of Beverly, Mass., said it has recruited the first patients with advanced solid tumors for clinical studies of cancer candidate Kevetrin

Hadasit Bio-Holdings Ltd., of Jerusalem, said portfolio company Enlivex completed a 13-patient clinical trial of cellular treatment ApoCell for graft-vs.-host disease (GvHD), with results indicating efficacy and safety in recipients of bone marrow transplants from foreign donors...The primary endpoint of the 33-patient study is to determine the clinical benefit rate, while secondary objectives include progression-free survival and safety and tolerability

Mirna will be the first company in clinical trials with a miRNA replacement therapy, and that fresh and different approach may have helped the company to attract its large, deep-pocketed investors...Shares of XOMA (NASDAQ:XOMA) fell 23 cents, to close at $2.99 Wednesday.

The funds were raised from accredited investors and will be used to advance multiple clinical development programs

The clinical relevance of neratinib as a 'pan-HER' family inhibitor and it being irreversible is yet to be proven," the paper said...Funds will be used to support the clinical development of cancer drugs aldoxorubicin and tamibarotene and for general corporate purposes, which could include working capital, capital expenditures, R&D and commercial activities.

Funds will be used to support the clinical development of cancer drugs aldoxorubicin and tamibarotene and for general corporate purposes, which could include working capital, capital expenditures, R&D and commercial activities...Net proceeds are expected to total $19.3 million and will be used for ongoing clinical development of dendritic cell-based vaccine ICT-107 and for general corporate purposes

Janssen Research & Development LLC, of Spring House, Pa., a unit of Johnson & Johnson, said a Phase IIb study testing Stelara (ustekinumab) in moderate to severe Crohn's disease showed that, among patients who had previously failed or were intolerant to at least one tumor necrosis factor antagonist, a significantly greater proportion receiving intravenous Stelara achieved the primary endpoint of clinical response at week six, defined as a 100-point reduction in Crohn's Disease Activity Index

The study showed that the drug was safe and well tolerated at all dose levels, and that more patients in the higher-dose cohorts showed improvement in their clinical disease activity index than patients in the lower-dose or placebo cohorts

The investors were very enthusiastic about the results from the Phase I/II clinical trial...APIM Therapeutics A/S, of Trondheim, Norway, closed a financing round to fund ATX-101, its lead compound, toward clinical trials...Proceeds would be used for R&D activities, clinical trials, investment in capital equipment and for working capital and other general corporate purposes

Intercept estimated that remaining clinical development for OCA for PBC will take about $40 million, and that the current offering, plus $29.8 million from its recent Series C financing, plus its cash will be enough to put it over the top. (See BioWorld Today, Sept. 6, 2012.) That clinical development includes completion of the POISE trial and initiation of its long-term safety extension, initiation of a Phase III outcomes trial, carcinogenicity studies in animals, a Phase I safety trial in