Nektar Therapeutics Inc., of San Carlos, Calif., said the first patients have been dosed in a Phase I dose-escalation study of NKTR-105, a PEGylated form of docetaxel...NeuroGeneration are planning a larger prospective clinical trial for Parkinson's disease

Dose escalation continues to determine the primary endpoints of the study, safety, pharmacokinetics and a Phase II dose...Pharmacokinetic data from a two-week, repeat-dose, proof-of-clinical-concept study and a single ascending-dose, first-time-in-human study conducted in healthy volunteers demonstrated that SPI-452 substantially enhanced the exposures of three currently approved HIV protease inhibitors

Cytopia Ltd., of Melbourne, Australia, successfully concluded dose escalation in its oral Phase I study for CYT997, its anticancer vascular-disrupting agent (VDA...Data were first presented at the 2008 annual meeting of the American Society of Clinical Oncology

The results from a Phase I dose-escalation study released in 2008 showed that Sym001 is safe and well tolerated, according to Symphogen...The money will be used to fund clinical trials for its lead product candidate, MyoCell, a muscle-derived stem cell therapy.

It has completed a Phase I dose-escalation trial in healthy volunteers and is proceeding to a Phase IIa, multiple-ascending dose trial in treatment-naive HIV-infected individuals...BDSI will be responsible for manufacturing and providing clinical trial materials

The Phase I/II, double-blind, placebo-controlled, dose-escalation study will evaluate the safety and antiviral activity of IDX184 in treatment-naive adult patients infected with chronic hepatitis C...Medicure Inc., of Winnipeg, Manitoba, said it started a clinical program to test Avastrem (pyridoxal 5'-phosphate) in tardive dyskinesia (TD

Secondary endpoints include clinical assessment, plain film radiographic evaluation and several functional and pain assessments...The company decided to put clinical development of HMPL-002 on hold based on the interim results...The first part of the study is a dose-escalation design to evaluate the safety and tolerability of a single intravenous injection of QPI-1002 in renal transplant patients at high risk to develop DGF

Marshall Edwards Inc., of North Ryde, Australia, said the FDA approved its investigational new drug application to undertake clinical studies with triphendiol as a chemosensitizing agent in combination with gemcitabine...The trial objectives are to assess safety and to determine the maximum tolerated dose and dose-limiting toxicity by applying a dose-escalation schedule with a limited number of patients and to define the recommended Phase II dose

Oxygen Biotherapeutics Inc., of Costa Mesa, Calif., said it filed a response to the FDA's request for information, which includes a synopsis of the company's revised protocol for a Phase II dose-escalation trial of Oxycyte, a perfluorocarbon therapeutic oxygen carrier, in traumatic brain injury...That study would focus on finding the lowest dose of Oxycyte that reduces thrombocytopenia and still provides clinical benefit in traumatic brain injury patients

Basilea Pharmaceutica Ltd., of Basel, Switzerland, said it had started a Phase III study on alitretinoin, known as the HAND Eczema research of aLitretinoin, which the firm said is the first ever multicenter, controlled clinical study for patients with severe chronic hand eczema (CHE) performed in the U.S. The HANDEL study will investigate the efficacy and safety of alitretinoin, a naturally occurring, physiologic retinoid, in the treatment of severe CHE that has not responded to potent topical

Ortho-McNeil's planned clinical studies also will include the evaluation of patients with Type II diabetes...The study is a dose-escalation trial expected to enroll up to 18 patients and to test three dose levels of FG-3019 administered via infusion every two weeks

The clinical safety report constitutes a major part of the data package that will be used to potentially support the use of Imvamune in a declared emergency...The final clinical study report is expected in early 2009...Data from a completed Phase I dose escalation trial of voreloxin as a single agent in acute leukemias (N = 73) showed that single-agent voreloxin was generally well tolerated, with the most frequently observed dose-limited toxicity being reversible grade 3/4 oral mucositis

Cytheris SA, of Paris, initiated a multicenter Phase I/IIa dose escalation study in Taiwan to assess the safety and tolerability of repeated administration of its immunotherapy, recombinant human Interleukin-7 (CYT107), as an add-on therapy in the treatment of patients infected with genotype 1 hepatitis C and who previously have proven nonresponsive to standard treatment...Phenomix Corp., of San Diego, has begun administering subjects in a Phase Ia clinical trial of PHX1766, its orally available

RGB-286638 is expected to enter Phase I clinical testing this year...Dose-escalation to find the dose corresponding to preclinical exposure levels where antitumor activity was observed in animal models is still continuing

In a separate presentation, the company said preliminary Phase I data from a dose-escalation trial of LX228 in patients with advanced malignancies showed that seven of 16 evaluable patients have experienced prolonged stable disease, with one metastatic non-small-cell lung cancer patient experiencing a 27 percent reduction in all target lesions as measured by RECIST criteria...In a third presentation, Exelixis reported preliminary Phase I data from a dose-escalation trial of XL281, a selective small

The trial is an open-label, dose-escalation study evaluating IPI-926 in approximately 30 to 50 patients with advanced and/or metastatic solid tumors...TZP-101 already is in clinical trials for the management of postoperative ileus and gastroparesis

That subgroup analysis is consistent with the recommendations of the Prostate Cancer Clinical Trials Working Group to measure prostate cancer progression in clinical studies...The primary objective of the dose-escalation component of the study is to establish the maximum tolerated dose and dose-limiting toxicities of TH-302 in combination with doxorubicin

The first portion of the study will involve up to 12 patients with a standard dose-escalation design, while the second part of the study will enroll up to 30 patients who will be randomized to receive the tolerated doses identified in the Phase I portion...The trial is designed to investigate the drug in combination with two marketed cancer agents, carboplatin and etoposide, in about 30 patients at clinical sites in Australia and overseas

The company received FDA and Health Canada approval for the clinical trial earlier this year...The trial is a dose-escalation study designed to evaluate the safety of PMX-30063