Pursuant to the terms, each of the company's ordinary shares, including shares represented by American depositary shares (ADS), will be cancelled in exchange for the right to receive $2.20 in each per share, or $15.40 per ADS...Due to the oversubscription, the closing unit price was set at NIS3.544 per unit

plc to the blockbuster multiple sclerosis (MS) therapy Tysabri (natalizumab) didn't take long for analysts to applaud, though Wall Street traders spent time digesting the $3.25 billion deal, which includes contingent payments...As others took the opportunity to note, Biogen's "strength is commercial execution and smart business development deals," Yee wrote

Other, sub-Saharan countries are at the very beginning...They wouldn't have to do this in a mature market, or in some of the other emerging markets, whether it's about education, or a secure distribution, or even pharmacovigilance, which they will have to build their own systems for

Diamyd Medical AB, of Stockholm, Sweden, said it's planning to start a new 60-patient study in February with diabetes vaccine Diamyd, testing it in combination with other drugs – relatively high doses of vitamin D and anti-inflammatory drug ibuprofen – to potentiate the effect of the vaccine's ability to help the body control blood sugar levels in newly diagnosed Type I diabetics

Other, sub-Saharan countries are at the very beginning...They wouldn't have to do this in a mature market, or in some of the other emerging markets, whether it's about education, or a secure distribution, or even pharmacovigilance, which they will have to build their own systems for

to test AXL1717, an oral small-molecule insulin-like growth factor 1 receptor inhibitor, in patients with malignant astrocytomas, a type of brain tumor...In other news, Novartis said the FDA approved a new use of Gleevec (imatinib) to treat children newly diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia

The design of the trial later will be adapted, enabling it to separate into three separate personalized arms to test AZD0424 in different combinations alongside standard or other experimental treatments in specific patient populations...In other news, Boehringer Ingelheim said it enrolled the first patients in its Phase III interferon-free (IFN-free) program, HCVerso, testing its IFN-free polymodal regimen combining faldaprevir (BI 201335), a next-wave once-daily protease inhibitor, and BI 207127

In other news, Evotec said a compound identified and optimized in a research collaboration with Osaka, Japan-based Ono Pharmaceutical Co...In separate news, Janssen reported that the FDA's Endocrinologic and Metabolic Drugs Advisory Committee voted 10-5 late Thursday to recommend approval of canaglifozin, a selective sodium glucose co-transporter 2 inhibitor, to treat Type II diabetes in adults

In other news, Evotec said it expanded its collaboration with MedImmune, part of London-based AstraZeneca plc, after hitting a key milestone...Under the agreement, Pepscan will use its CLIPS platform and other protein mimicry technologies to help discover new antibodies

Public biopharmaceutical companies, which had a great year, by and large were not able to fully leverage their increased stock valuations, successful clinical results and product approvals into follow-on and other financings...The company paid $350 million in cash, with the remainder made up of milestones: $195 million related to the development and regulatory approval of Bruton's tyrosine kinase (Btk) inhibitor AVL-292, and up to $380 million in potential payments contingent upon the development

As seen in that study, the gold nanoparticles trafficked to tumors, not to healthy tissue, resulting in an improvement in the safety of systemically administered TNF formulated as CYT-6091...OJSC RVC, of Moscow, started a program to acquire new investments and support new projects in medical science and biotechnology, energy efficiency, information technology and telecommunications...The companies disclosed in August 2011 their decision to discontinue the development of pramlintide plus metreleptin

Gentium expects to receive an opinion from the agency regarding the approval of defibrotide during the first quarter of 2013...It is designed to compare the effects of an optimized background drug regimen alone to an optimized background regimen plus SQ109...Infectex licensed rights to the drug from Sequella Inc., of Rockville, Md

to Firdapse, a drug in development for Lambert-Eaton myasthenic syndrome BioMarin agreed to invest $5M in Catalyst under a promissory note and note purchase agreement 11/1/12 Colby Pharmaceutical Co. (San Jose, Calif.) MannKind Corp. (Valencia, Calif.) $140 Deal for disease-specific antigen compounds and intra-lymph node injection (INLI) technologies from its MKC1106 cancer vaccine program Colby is paying up to $140M in up-front and milestone payments to MannKind, which also will receive tiered

BIT225 is designed to specifically target HIV in reservoir cells to stop the ongoing cycle of infection in the body...Those and other data were presented at the American Society of Hematology meeting in Atlanta

Distribution of Prothena ordinary shares in the demerger is conditioned upon, among other conditions to the demerger, a registration statement filed with the SEC, having been declared effective by the SEC and the affirmative vote of the Elan shareholders...Galderma will continue to supply Restylane and Perlane to Valeant under the same terms and conditions that the products are supplied to Medicis, while Valeant will make undisclosed up-front and royalty payments to Galderma on sales of Sculptra...To

In other news, Bayer said its BAY 86-6150 is being investigated in a Phase II/III study, dubbed TRUST (TReatment with Unique recombinant rFVIIa STudy), and the recruitment of the first cohort is now complete...In other news, Viralytics is offering shareholders up to $15,000 worth of shares at 30 cents each in a new underwritten share purchase plan to fund the company's intravenous cancer trial and the continued clinical research and development of Cavatak, its lead oncolytic virus candidate

Details Date Advaxis Inc. (Princeton, N.J.) Private placement N/A $10 Advaxis secured $10M in equity financing from Magna Group LLC 11/1/12 Amarantus BioSciences Inc. (Sunnyvale, Calif.) Private placement N/A $1.1 Amarantus secured $1.1M in funding through two separate transactions, by issuing a convertible promissory note to an undisclosed investor in the principal amount of $600,000 and, with an institutional fund, settled more than $500,000 in accounts payable 11/15/12 Ambit Biosciences Inc

The randomized, sham-controlled, blind trial will compare C3BS-CQR-1 to a sham therapy in at least 240 patients with a primary composite endpoint of mortality, morbidity, quality of life and other measures at nine months after the procedure...Other investors included Alta Partners, Quest for Growth and NOM...The goal is to develop therapies to treat a number of rare pediatric diseases with high unmet medical need using Boston Children's research expertise and Shire's development and commercialization

to treat central nervous system disorders BioFocus will use its drug discovery platform to deliver leads and clinical candidates for the Japanese company 9/5/12 Imprimis Pharmaceuticals Inc. (Solana Beach, Calif.) Professional Compounding Centers of America Inc. (Houston) $4 Agreement to develop and share drug formulation technology with the goal of creating a new generation of topical and therapeutic treatments for muscle and joint pain, neuropathic pain and other conditions Terms were not