Sorrento Therapeutics Inc., of San Diego, said it acquired worldwide rights to allow for the application of its antibody library technology for the production of recombinant intravenous immunoglobulins...to-BBB Technologies BV, of Leiden, the Netherlands, entered a collaboration with the ALS Therapy Development Institute (ALS TDI) in Cambridge, Mass., to investigate potential treatments for amyotrophic lateral sclerosis

Under the agreement, Pepscan will use its CLIPS platform and other protein mimicry technologies to help discover new antibodies...to purchase up to 1 million shares, or about 1.06 percent of the company's outstanding stock, at a price of $161.25 per share, marking a 4.46 percent discount to the Dec. 27 closing price

Aragon Pharmaceuticals Inc., of San Diego, said that the Superior Court of California, County of San Francisco, granted summary adjudication in Aragon's favor on its Complaint in Intervention against Medivation Inc...The change is expected to allow the firm to explore various strategic options as it moves forward with its programs in oncology and immune-modulatory diseases...Terlipressin is designed to reduce portal vein pressure and increase mean arterial pressure in cirrhotic patients with

Auxilium Pharmaceuticals Inc., of Malvern, Pa., and Xstelos Holdings Inc., of New York, said they received notice that Upsher-Smith Laboratories Inc., of San Diego, filed a 505(b)(2) new drug application containing a Paragraph IV certification for testosterone gel, referring to 10 U.S...NGM Biopharmaceuticals Inc., of South San Francisco, said it inked a worldwide deal with Janssen Pharmaceuticals Inc., a unit of New Brunswick, N.J.-based Johnson & Johnson, to discover and develop therapeutics to

Victory Pharma Inc., of San Diego, will pay $11,420,743 to resolve liabilities resulting from marking of Naprelan, Xodol, Fexmid and Dolgic, according to the Justice Department...Those alleged kickbacks included tickets to sporting events and concerts, spa outings, golf and ski outings, restaurants and many other events

Halozyme will also be entitled to royalty payments based on net sales of any licensed products...The news of the Pfizer deal received a positive reception with the company's share price (NASDAQ:HALO) closing Friday at $7.01, up a healthy 27 percent on the day...While investors reacted positively to the announcement, Jeffries & Co

Trovagene Inc., of San Diego, said it granted Genoptix Inc., a unit of Basel, Switzerland-based Novartis AG, a worldwide, nonexclusive license to incorporate nucleophosmin protein, or NPM1, into research and clinical testing services for acute myelogenous leukemia

The company gained commercialization rights to the drug for Canada, South America and Africa in 2001 from Somaxon Pharmaceuticals Inc., of San Diego, which recently agreed to be acquired by Pernix Therapeutics Holdings Inc., of The Woodlands, Texas, in an all-stock deal valued at $25 million

Genzyme plans to request a re-examination of the CHMP Opinion...Ligand Pharmaceuticals Inc., of San Diego, and Pfizer Inc., of New York, said the FDA accepted for review a new drug application for bazedoxifene/conjugated estrogens (BZA/CE), a potential new medicine for non-hysterectomized women for the treatment of moderate-to-severe vasomotor symptoms and vulvar and vaginal atrophy associated with menopause, as well as the prevention of postmenopausal osteoporosis

In a flash note, she observed that, with respect to pharmacokinetics, "it's unclear whether PI3K gamma inhibition by IPI-145 has meaningful contribution to anticancer activity...OncoSec plans to use the proceeds to fund clinical trials and research and development and for other corporate purposes...The company plans to use the proceeds to fund research and development, clinical trials and for other corporate purposes.

Somaxon Pharmaceuticals Inc., of San Diego, is facing an investigation on behalf of shareholders by former SEC attorney Willie Briscoe and securities litigation firm Powers Taylor LLC into the company's sale to Pernix Therapeutics Inc., of The Woodlands, Texas...According to the approved product labeling, the treatment may now be used as a first-line agent or concomitantly with other topical ophthalmic drug products to lower IOP

Pernix Therapeutics Holdings Inc., of The Woodlands, Texas, agreed to acquire Somaxon Pharmaceuticals Inc., of San Diego, in an all-stock transaction...Shares of Somaxon (NASDAQ:SOMX) soared on the buyout news, gaining 80.3 percent, or $1.18, to close Tuesday at $2.65. (See BioWorld Today, March 19, 2010, July 16, 2010, Aug. 26, 2010, and June 9, 2011

Distribution of Prothena ordinary shares in the demerger is conditioned upon, among other conditions to the demerger, a registration statement filed with the SEC, having been declared effective by the SEC and the affirmative vote of the Elan shareholders...Galderma will continue to supply Restylane and Perlane to Valeant under the same terms and conditions that the products are supplied to Medicis, while Valeant will make undisclosed up-front and royalty payments to Galderma on sales of Sculptra...To

Payments to Isis could total $200 million, including license fees and regulatory milestones per program, plus additional double-digit royalties...Geron agreed to assign to TA Sciences Inc., of New York, those patents previously licensed to Asia Biotech, including intellectual property relating to telomerase activation technology...Halozyme Therapeutics Inc., of San Diego, said partner Roche AG, of Basel, Switzerland, submitted a line extension application to the European Medicines Agency for a

The company plans to direct its cash and other resources primarily to enable the achievement of important near-term milestones for its BCX4161 HAE, BCX4430 broad-spectrum antiviral and BCX5191 hepatitis C programs

Immunomedics Inc., of San Diego, reported the development of two bi-specific, hexavalent antibodies created using the company's patented Dock-and-Lock conjugation technology for targeted therapies of various epithelial cancers...Vical Inc., of San Diego, said it inked a worldwide, nonexclusive license for rights to its Vaxfectin adjuvant to Cyvax Inc., a privately held vaccine firm, for use in malaria vaccines

In other news, Bayer said its BAY 86-6150 is being investigated in a Phase II/III study, dubbed TRUST (TReatment with Unique recombinant rFVIIa STudy), and the recruitment of the first cohort is now complete...In other news, Viralytics is offering shareholders up to $15,000 worth of shares at 30 cents each in a new underwritten share purchase plan to fund the company's intravenous cancer trial and the continued clinical research and development of Cavatak, its lead oncolytic virus candidate

AnaptysBio Inc., of San Diego, reported in Protein Engineering, Design & Selection a full-length antibody scaffold, applicable to the development of highly thermostable antibodies for therapeutic and diagnostic applications...To date, none of the gene targets associated with the obese phenotype has provided a viable drug therapy

note to an undisclosed investor in the principal amount of $600,000 and, with an institutional fund, settled more than $500,000 in accounts payable 11/15/12 Ambit Biosciences Inc. (San Diego) Private placement N/A $50 Ambit raised $50M from existing investors, including OrbiMed Advisors, Aisling Capital, Apposite Healthcare, Roche Ventures, GrowthWorks, MedImmune Ventures, Forward Ventures, GIMV and Radius Ventures 11/7/12 Arno Therapeutics Inc. (Flemington, N.J.) Private placement of