The study is being sponsored by the Alliance for Clinical Trials in Oncology, a cooperative group of the National Cancer Institute (NCI...In the trial, aldoxorubicin showed prolonged clinical activity, including partial tumor response, in two subjects with small-cell lung cancer who had failed other therapies...Promedior Inc., of Lexington, Mass., presented data from a clinical study of PRM-151 at the American Thoracic Society Conference in Philadelphia

But the growing interest in the virology space, thanks largely to the leaps made in hepatitis C in the past few years, is bringing more attention to HBV...The firm also has programs in two big pharma partnerships

Critics of the firm, too, have pointed to the lack of a big pharma partner to expand Qsymia's reach. (See BioWorld Today, Oct. 23, 2012.) Lief said Belviq already has picked up some momentum...The drug was included in a recent diabetes management report from the American Association of Clinical Endocrinologists...But Wall Street was more than willing to overlook that miss, sending shares of Gilead (NASDAQ:GILD) up $2.97 to close Friday at $55.15, in favor of enthusiasm for the firm's much-lauded

Last month, it inked a deal with AbbVie, of Chicago, giving the big pharma firm an option to RPC4046 following the Phase II proof-of-concept trial in EoE...MEI Pharma Inc., of San Diego, priced a public offering of about 2 million shares of common stock at $7.50 apiece, a 9.5 percent discount to Thursday's closing price...Funds will be used to progress the clinical development program for lead candidate, Pracinostat, its oral histone deacetylase inhibitor for advanced hematologic malignancies, and for

Another $406 million could come in the form of clinical, regulatory and commercial milestones, and Enanta would be eligible for tiered, double-digit royalties and a U.S...and London-based GW Pharma plc, which is seeking a Nasdaq listing and a capital raise. (See BioWorld Today, March 11, 2013, March 12, 2013, and March 20, 2013.) In other financings news...Net proceeds are expected to support clinical trial costs and acquisition of manufacturing equipment, leasehold improvements and general corporate

Boehringer Ingelheim Pharmaceuticals Inc., of Ridgefield, Conn., part of Boehringer Ingelheim GmbH, reported the first interim results in HCV/HIV co-infected patients from the company's ongoing hepatitis C (HCV) clinical trial program, HCVerso...Polyphor Ltd., of Allschwil, Switzerland, completed a Phase I trial demonstrating the clinical safety and tolerability of its Pseudomonas-specific antibiotic POL7080

Cerulean Pharma Inc., of Cambridge, Mass., said CRLX101 achieved the predefined gating criterion for advancement into the second stage of a Phase II trial in advanced ovarian cancer...That allows Lorus to initiate a biomarker clinical investigation to further explore the effects of the drug at relevant doses determined in the trial...The complete clinical study report for the interim analysis would be supplied to the FDA during the review within 60 days of the resubmission

The drugs are being developed for hepatitis C virus...CellAct Pharma GmbH, of Dortmund, Germany, said its topoisomerase inhibitor CAP7

We were losing a lot of patients to these clinical trials...I'm not satisfied with this performance and not looking at clinical trials as an excuse," Johnson said...The FDA granted Xtandi (enzalutamide, Astellas Pharma Inc. and Medivation Inc.) approval in September for metastatic castration-resistant prostate cancer patients who have previously received docetaxel. (See BioWorld Today, Sept. 4, 2012.) Dendreon said it is looking for a European marketing partner, rather than just a manufacturing

Eaton Scientific Solutions Ltd., of Beverly Hills, Calif., a subsidiary of Pristine Solutions Inc., said it is finalizing preparations for a clinical program testing Tropine 3, which contains FDA-approved anticholinergic drug Homatropine, in an oral suspension...Proacta Inc., of San Diego, said the FDA cleared its investigational new drug application for clinical testing of PR610, a hypoxia-activated, irreversible multikinase inhibitor aimed at treating cancer...The first clinical study, to be

Agenus Inc., of Lexington, Mass., said clinical data from a Phase I trial of a Prophage Series vaccine (HSPPC-96, vitespen) to treat patients with recurrent glioblastoma multiforme (GBM) were published online by Clinical Cancer Research...Clavis Pharma ASA, of Oslo, Norway, said its partner Clovis Oncology Inc., of Boulder, Colo., initiated a Phase I study of CP-4126 (CO-101) in combination with cisplatin in non-small-cell lung cancer (NSCLC

If this pivotal preclinical study pans out, we'll try to move into human clinical trials as soon as feasible," Marshall said...miRagen's compounds were developed under a 2010 partnership deal with Santaris Pharma A/S using its Locked Nucleic Acid (LNA) platform...Rodman & Renshaw LLC acted as exclusive placement agent.

Novartis AG, of Basel, Switzerland, said the FDA has placed a full clinical hold on the development program of DEB025 (alisporivir), a first-in-class cyclophilin inhibitor being tested in hepatitis C, following the death of a patient and a number of reported cases of pancreatitis

Three smashing clinical successes by Gilead Sciences Inc.'s nuc drug GS-7977 for hepatitis C virus (HCV) have lit up the 2012 International Liver Congress of the European Association for the Study of the Liver, sending the company's stock up 12 percent Thursday

support clinical development of chemotherapeutic gold nanoparticles targeting ovarian, lung and breast carcinoma...The company plans to use the proceeds to advance its hepatitis C virus program, earlier-stage pipeline opportunities and its screening platform.

Metabolex Inc., of Hayward, Calif., said an open-label clinical pharmacology study showed that the higher dose of arhalofenate plus Osaka, Japan-based Takeda Pharmaceutical Co...Tranzyme Pharma Inc., of Research Triangle Park, N.C., and Norgine BV, of Amsterdam, the Netherlands, completed patient enrollment in ULISES 007, the first of two pivotal Phase III studies of ulimorelin, an intravenous ghrelin agonist, for the acceleration of gastrointestinal recovery in patients undergoing partial bowel

Achillion Pharmaceuticals Inc., of New Haven, Conn., reported Phase Ib data showing that ACH-2928, a first-generation NS5A inhibitor, produced a mean maximum 4.68 log10 reduction in hepatitis C virus (HCV) RNA in patients treated with a three-day monotherapy of 60 mg once daily...The open-label study is designed to test safety, tolerability and clinical response activity of the drug in patients, 60 and older, who have relapsed or primary refractory disease...Zealand Pharma A/S, of Copenhagen, Denmark

But, if data for INX-189 continue to flow positive, the company could find itself in an enviable position for a lucrative big pharma partnership or even an acquisition, as biopharma races to create the first all-oral, interferon-free HCV regimen...Proceeds will be used to accelerate the firm's drug development pipeline, including generating clinical data from partnerships in Russia and India.

Conatus Pharmaceuticals Inc., of San Diego, terminated its Phase II trial of CTS-1027 in hepatitis C patients...The decision follows reports of laboratory abnormalities and adverse events in a subset of clinical trial participants...Solasia Pharma K.K., of Tokyo, reported that enrollment of a Phase I trial evaluating the safety and tolerability of darinaparsin injection (SP-02L) for the treatment of peripheral T-cell lymphoma (PTCL) has commenced in Japan